Results 51 to 60 of about 1,056,363 (297)
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source
Frontiers in Earth Science, 2022 The Manta-Ray Foraging Optimization has been adapted and implemented in computing model parameters from potential field anomalies originating from two-dimensional dipping faults.
Ubong C. Ben +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source
Structural pattern of the Todos Santos Coastal Plain, based on geophysical data
Ciencias Marinas, 2004 A set of gravity and magnetic data taken within the Todos Santos Coastal Plain between 1962 and 2000 from land, sea and air is used to integrate the structural framework and tectonic model of this area. The present work collected all the available data,
MA Pérez-Flores +4 more
doaj +1 more source
Magnetic forces in and on a magnet
Discrete & Continuous Dynamical Systems - S, 2019 Given the shape of a magnet and its magnetization, point by point, which force does it exert on itself, also point by point? We explain what 'force' means in such a context and how to define it by using the Virtual Power Principle. Mathematically speaking, this force is a vector-valued distribution, with Dirac-like concentrations on surfaces across ...
openaire +3 more sources
Molecular Oncology, EarlyView.Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
Imaging the Mahout structure at the Oman desert with the aid of geophysical observations
Frontiers in Earth ScienceGeophysical methods may provide crucial information for the characterization of buried impact structures. In this study, we report and comment on the results of the geophysical survey of an elliptical-shaped structure near Mahout at Oman’s central desert.
Sobhi Nasir +4 more
doaj +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source