Results 61 to 70 of about 1,114,374 (290)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
The management of intelligence-assisted finite element analysis technology [PDF]
, 1997 Artificial Intelligence (AI) approaches to Finite Element Analysis (FEA), have had tentative degrees of success over the last few years and some authors have argued that effective FEA can help in the manufacture reliability and safety aspects of ...
Sharif, AM
core
Fringing in tubular permanent-magnet machines: Part II. Cogging force and its minimization [PDF]
, 2003 In Part I of the paper, analytical field solutions, which account for the fringing flux associated with the finite length of the ferromagnetic armature core in tubular permanent-magnet machines, are established.
Howe, D., Jewell, G.W., Wang, J.B.
core +1 more source
Segmenting electroencephalography wires reduces radiofrequency shielding artifacts in simultaneous electroencephalography and functional magnetic resonance imaging at 7 T [PDF]
, 2022 Thanh Phong Lê +3 more
openalex +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
AC magnetic trap for cold paramagnetic molecules [PDF]
, 2023 Shengqiang Li +3 more
openalex +1 more source
FEBS Open Bio, EarlyView.This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso +4 more
wiley +1 more source
Micro-Structured Ferromagnetic Tubes for Spin Wave Excitation
, 2010 Micron scale ferromagnetic tubes placed on the ends of ferromagnetic CoTaZr spin waveguides are explored in order to enhance the excitation of Backward Volume Magnetostatic Spin Waves.
Allen, S. J. +5 more
core +1 more source
DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling
FEBS Open Bio, EarlyView.Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang +7 more
wiley +1 more source