Results 121 to 130 of about 16,270,905 (298)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Research on the Mechanism and Prediction Model of Pressure Drive Recovery in Low-Permeability Oil Reservoirs

Energies
China boasts significant reserves of low-permeability oil reservoirs, and the economic and efficient development of these reservoirs plays a crucial role in enhancing oil and gas production. However, the “difficult injection and difficult recovery” issue
Haicheng Liu, Binshan Ju
doaj   +1 more source

Main Controlling Factors and Models of Organic Matter Accumulation in Lower Carboniferous Dawuba Formation Shale in Southern Guizhou, China. [PDF]

ACS Omega, 2021
Niu J, Zhang J, Tang X, Yuan K, Lin T, Liu Y, Niu Y, Li P, Li X, Liang Y.   +9 more
europepmc   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Distribution rules, main controlling factors and exploration directions of giant gas fields in the Sichuan Basin

, 2020
Over the past decade, great progresses have been made in natural gas exploration in the Sichuan Basin, where several large gas fields (such as Anyue) have been discovered.
Wei Yang, Saijun Wu, Nan Su, Hui Jin, Guoqi Wei, Juehong Shen, Wuren Xie, Mancang Liu, Cuiguo Hao   +8 more
core   +1 more source

Geological characteristics of deep coal rock and main geological factors controlling coalbed methane enrichment: a case study of the M area in the eastern Ordos Basin

Shiyou shiyan dizhi
The 8# thick coal seam is widely distributed with high organic matter thermal maturity at the top of the Upper Carboniferous Benxi Formation in the M area of the Ordos Basin.
Xiaojiao GUO, Lei WANG, Xianzhou YAO, Xu LI, Linke ZHANG, Xiaoshuang WANG   +5 more
doaj   +1 more source

Full-Scale Pore Structure Characteristics and the Main Controlling Factors of Mesoproterozoic Xiamaling Shale in Zhangjiakou, Hebei, China. [PDF]

Nanomaterials (Basel), 2021
Xu L, Yang K, Wei H, Liu L, Li X, Chen L, Xu T, Wang X.   +7 more
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Three-dimensional void fraction evolution law and sensitivity analysis of mining-induced overburden based on Bertalanffy time function

Scientific Reports
The voids in overlying strata caused by coal mining are prone to induce geological hazards. To reveal the evolution of overburden voids, a three-dimensional dynamic void fraction (VF) model based on the Bertalanffy time function was constructed and ...
Zejun Li, Nan Zhou, YiZhu Lei, Qiming Yang, Meng Li, Hao Yan, Baiyi Li   +6 more
doaj   +1 more source

Fluid pressure gradient characteristics and petroleum geological significance in Shahejie Formation of Bonan Sag in Jiyang Depression

Shiyou shiyan dizhi
Fluid pressure gradient is the rate at which residual fluid pressure changes both spatially and temporally. It serves as an important parameter for indicating oil and gas migration pathways and accumulation zones, holding great geological significance ...
Peng LIU, Tao MENG, Fatang YAN, Zhongxin LI, Chengcheng SHAN   +4 more
doaj   +1 more source