Results 121 to 130 of about 15,385,090 (308)

A kínai kis és középvállalkozások controlling sajátosságai

, 2022
SMEs have benefited from the rapid development of marketisation and the globalisation dividend, but their risk aversion is insufficient and they are often the most vulnerable when faced with market changes or unexpected situations. Therefore, in order to
Xu, Xiaoyue
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Regulation mechanism of slickwater on desorption interface of deep coalbed methane

Duankuai youqitian
Aiming at the problems of difficult desorption of deep coalbed methane (methane) and low productivity after fracturing in the development of deep coalbed methane in Daniudi Gasfield, experiments such as methane desorption performance testing, core damage
LUO Yi,FANG Yanjun,QIAO Qianyu
doaj   +1 more source

Controlling and Cost Management System of Nyírségvíz Zrt.

, 2011
Dolgozatomban a Nyírségvíz Zrt controlling és költséggazdálkodási rendszerét mutattam be. A mai gazdasági környezetben szükséges, hogy a vezetők mindig a legmegfelelőbb döntéseket hozzák. Ezeknek a döntéseknek a meghozatalában segít a controlling.
Somogyi, Enikő
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Controlling a Nemzeti Dohányboltok világában

, 2017
Dolgozatomban a gyakorlati helyemen elvégzett controlling feladatokat jellemzem, illetve a Nemzeti Dohányboltokkal kapcsolatos tevékenységeket, szabályozásokat mutatom be.KEGazdálkodási és Menedzsment FOSZfelsőoktatási ...
Harangi, Csilla Bianka
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Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Hydrocarbon accumulation characteristics and main controlling factors of major salt-bearing basins in Central Asia

Shiyou shiyan dizhi
The Amu Darya Basin and the Pre-Caspian Basin in Central Asia hold enormous hydrocarbon resource potential and are the most representative salt-bearing basins in the region.
Li LIU, Kaixun ZHANG, Gang YU, Linjun YU, Haihua QIU, Yan ZHOU, Beiqi GE, Bakhtier NURTAEV, Shukhrat SHUKUROV   +8 more
doaj   +1 more source

A CLAAS Hungária Kft. controlling rendszerének elemző bemutatása

, 2013
Diplomamunkám témája a napjaink dinamikusan változó üzleti környezetében a vállalatok gyors reagálását és rugalmas alkalmazkodását hatékonyan támogató controlling funkció vizsgálata. A dolgozat alapvetően két fő egységre tagolódik.
Szabó, Viktória
core