Results 131 to 140 of about 16,270,905 (298)

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Analysis and risk assessment of main controlling factors of water inrush in shallow coal seam mining under gully

Meitan kexue jishu
To investigate the problem of mine water inrush in shallow coal seam mining under gully water body, taking 22104 working face of a coal mine in Ordos as the engineering background, the main controlling factors and risk assessment methods of mine water ...
Benhuan GUO, Shihao TU, Kaijun MIAO, Long TANG, Hongbin ZHAO   +4 more
doaj   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Main controlling factors and evolutionary model of organic matter enrichment in the Upper Permian Dalong Formation, Lower Yangtze region, South China

Shiyou shiyan dizhi
The shales of the Upper Permian Dalong Formation in the Lower Yangtze region, South China, constitute important hydrocarbon source rocks. However, the dynamic evolution of the mechanisms and controlling factors governing organic matter enrichment remains
Yubing Ji, Chengcheng Zhang, Chaogang Fang, Long Teng, Jianqing Li, Jiehui Zhang, Jiangnan Yang   +6 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Hydrocarbon accumulation characteristics and main controlling factors of major salt-bearing basins in Central Asia

Shiyou shiyan dizhi
The Amu Darya Basin and the Pre-Caspian Basin in Central Asia hold enormous hydrocarbon resource potential and are the most representative salt-bearing basins in the region.
Li LIU, Kaixun ZHANG, Gang YU, Linjun YU, Haihua QIU, Yan ZHOU, Beiqi GE, Bakhtier NURTAEV, Shukhrat SHUKUROV   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Absence of prenatal control: What are the main associated factors?

Conocimiento para el Desarrollo, 2019
Yovany Fernández, Grevillí Garcìa, Arely Estrada, Olaya Kassandra   +3 more
openaire   +2 more sources