Results 131 to 140 of about 15,385,090 (308)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Beyond violations : human factors in maintenance failures

, 2007
Human factors are recognised as influencing the performance of workgroups in industrial operations. Surveys and interventions in high-risk industries, notably commercial aviation and power generation, have highlighted the practical implications of a ...
Antonovsky, Ari, Pollock, Clare M. (R20416)   +1 more
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A Magyar Hipermarket Kft controlling rendszerének bemutatása

, 2010
A controlling elméleti bemutatása és egy vállalati példán való elemzése.vtgazdálkodás és ...
Bölcsházy-Kókán, Ildikó
core  

Prediction of mine strata behaviors law and main control factors in the fully mechanized caving face of Hujiahe Coal Mine

Gong-kuang zidonghua
Among the existing prediction methods for strata behaviors law in working faces, the methods based on numerical simulation and statistical regression cannot achieve real-time and precise prediction of strata behaviors law in working faces.
XI Guojun, YU Zhimi, LI Liang, LI Xiaofei, DING Ziwei, LIU Jiang, ZHANG Chaofan   +6 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Pore development characteristics and main controlling factors of tight oil reservoir in the seventh member of Triassic Yanchang Formation, Xunyi area, Ordos Basin

Shiyou shiyan dizhi
The seventh member of the Triassic Yanchang Formation (Chang 7 Member) in the Xunyi area of the Ordos Basin is a typical tight oil reservoir characterized by low porosity, low permeability, and strong heterogeneity.
Liangjun WANG, Xinxin YUE, Liansheng LI, Yanpeng WANG   +3 more
doaj   +1 more source

Absence of prenatal control: What are the main associated factors?

Conocimiento para el Desarrollo, 2019
Yovany Fernández, Grevillí Garcìa, Arely Estrada, Olaya Kassandra   +3 more
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Operatives F-/E-Controlling

, 2022
S.1-20 (Abschnitt 9.6)Operatives FuE-Controlling wird projektbezogen und bereichsbezogen durchgeführt. Grundlage für das projektbezogene Controlling sind die im Pflichtenheft festgelegten Ziele.
Pleschak, F.
core