Results 111 to 120 of about 3,154,545 (339)

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Improving Source Code Quality by Minimizing Refactoring Effort

open access: yesIlkom Jurnal Ilmiah
Software maintenance is a time-consuming and costly endeavor. As a part of maintenance, refactoring is aimed at enhancing quality. Due to project deadlines and limited resources, developers need to prioritize refactoring activities.
Hayatou Oumarou, Kabirrou Hamadou Tizi
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

open access: yesFEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom   +3 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Maintainability Analysis of Remotely Operated LNG Marine Loading Arms Based on UNE 151001 Standard

open access: yesMachines
The operation of liquefied natural gas (LNG) marine loading arms plays a pivotal role in the efficient transfer of LNG from maritime vessels to downstream facilities, underpinning the global LNG supply chain.
Fabian Orellana   +3 more
doaj   +1 more source

The Sea Urchin sns5 Insulator Protects Retroviral Vectors From Chromosomal Position Effects by Maintaining Active Chromatin Structure [PDF]

open access: hybrid, 2009
Danilo D’Apolito   +9 more
openalex   +1 more source

Home - About - Disclaimer - Privacy