Results 91 to 100 of about 13,846 (260)
CyNEST: a maintainable Cython-based interface for the NEST simulator
Frontiers in Neuroinformatics, 2014 NEST is a simulator for large-scale networks of spiking point neuron models (Gewaltig and Diesmann, 2007). Originally, simulations were controlled via the Simulation Language Interpreter (SLI), a built-in scripting facility implementing a language ...
Yury V. Zaytsev +4 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Robust engineering in maintainability of building [PDF]
, 2018 The process of designing a building is dependent on many requirements. Maintainability is an important design aspect that will affect the cost for management and the maintenance of a building within its expected life cycle.
Ismail, Neza
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
International Journal of Information Systems and Project Management, 2021 With the increasing ability to generate actionable insight from data, the field of data science has seen significant growth. As more teams develop data science solutions, the analytical code they develop will need to be enhanced in the future, by an ...
Jeffrey S. Saltz +3 more
doaj
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Reliability and maintainability program [PDF]
, 1981 The program's goals are to accelerate the adoption of active solar energy systems in building applications by improving the reliability and maintainability of installed systems.
Eden, A.
core
Evaluating Maintainability of Open Source Software
, 2017 Maintainability is one of the most important quality attribute that affect the quality of software. There are four factors that affect the maintainability of software which are: analyzability, changeability, stability, and testability.
Ahmad A. Saifan +4 more
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Assessing optimal software architecture maintainability
, 2001 Over the last decade, several authors have studied the maintainability of software architecture. In particular, the assessment of maintainability has received attention.
Po Bengtsson, Jan Bosch
core