Results 71 to 80 of about 3,154,545 (339)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
FEBS Letters, EarlyView.In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley +1 more source
An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots
FEBS Letters, EarlyView.This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino +7 more
wiley +1 more source
A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
FEBS Letters, EarlyView.We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source
RAM analysis of earth pressure balance tunnel boring machines: A case study [PDF]
International Journal of Mining and Geo-Engineering, 2015 Earth pressure balance tunnel boring machines (EPB-TBMs) are favorably applied in urban tunneling projects. Despite their numerous advantages, considerable delays and high maintenance cost are the main disadvantages these machines suffer from ...
Hasel Amini Khoshalan +3 more
doaj
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Comparative Analysis of Object-Oriented Software Maintainability Prediction Models
Foundations of Computing and Decision Sciences, 2018 Software maintainability is one of the most important aspects when evaluating the quality of a software product. It is defined as the ease with which the existing software can be modified.
Zighed Narimane +2 more
doaj +1 more source
An Experimental Evaluation of The Effect of SOLID Principles to Microsoft vs Code Metrics
Online Academic Journal of Information Technology, 2018 Software maintenance is necessary for reasons such as changes in user needs, changes in the operating conditions of the system due to changes in the infrastructure, the occurrence of unforeseen errors.
Osman Turan, Ömer Özgür Tanrıöver
doaj +1 more source
Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
Maintainability Assessment during the Design Phase: Integrating MTA and UNE 151001
MachinesThe focus on maintenance actions in the early design phases has been a trend in recent years. The main sources of information during the design of the maintainability process include operator reports, maintainer experience, failure history, and ...
Franco Donaire +3 more
doaj +1 more source