Results 161 to 170 of about 6,268,728 (387)

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

The Effect of Two Weight Reduction Maintenance Strategies for Moderately/Mildly Retarded Adults [PDF]

open access: yes, 1986
Thirteen retarded adult subjects were first exposed to a 12-week behavior therapy weight reduction program followed by a ten-month weekly weigh-in. Then the subjects were randomly assigned to an experimental maintenance booster session group (n=7) or a ...
Fox, Robert   +5 more
core   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Study on mechanical properties of aeronautical composite material interference-fit structures in hygrothermal service

open access: yesHangkong gongcheng jinzhan
Currently,the study on the influence of hygrothermal environment on composite material is more inclined to the material composition structure,rather than the composite connection.
QIU Hongjun   +4 more
doaj   +1 more source

Condition-based maintenance at both scheduled and unscheduled opportunities [PDF]

open access: yes, 2016
Motivated by original equipment manufacturer (OEM) service and maintenance practices we consider a single component subject to replacements at failure instances and two types of preventive maintenance opportunities: scheduled, which occur due to periodic
Kalosi, Szilard   +2 more
core   +2 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

Knowledge-based and Expert Systems in Prognostics and Health Management: a Survey

open access: yesInternational Journal of Prognostics and Health Management
Prognostics and Health Management (PHM) has become increasingly popular in recent years, and data-driven methods and artificial intelligence have emerged as dominant tools within the PHM field.
Kalil Bouhadra, Florent Forest
doaj   +1 more source

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