Results 31 to 40 of about 310,072 (254)

Investigating a cluster of pediatric oncology invasive fungal infections–Lessons learned

Antimicrobial Stewardship & Healthcare Epidemiology, 2022
Background: In spring 2021, the infection prevention and control department at a pediatric academic medical center identified 3 oncology patients with concern for invasive Rhizopus spp infections.
Angelette Terk, Jennifer Ormsby, Paula Conrad, Catherine Svensson, David Barry, David Davis, Ana Vaughan Malloy, Tom Sandora   +7 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Dissecting infant leukemia developmental origins with a hemogenic gastruloid model

eLife
Current in vitro models of developmental blood formation lack spatio-temporal accuracy and weakly replicate successive waves of hematopoiesis. Herein, we describe a mouse embryonic stem cell (SC)-derived 3D hemogenic gastruloid (haemGx) that captures ...
Denise Ragusa, Chun Wai Suen, Gabriel Torregrosa Cortes, Fabio Pastorino, Ayona Johns, Ylenia Cicirò, Liza Dijkhuis, Susanne van den Brink, Michele Cilli, Connor Byrne, Giulia-Andreea Ionescu, Joana Cerveira, Kamil R Kranc, Victor Hernandez-Hernandez, Mirco Ponzoni, Anna Bigas, Jordi Garcia-Ojalvo, Alfonso Martínez Arias, Cristina Pina   +18 more
doaj   +1 more source

Hypervolemia screening in predialysis healthcare for hemodialysis patients using fuzzy color reason analysis

International Journal of Distributed Sensor Networks, 2017
Maintaining adequate dry weight and fluid volume balance is an important issue for dialysis patients. Malnutrition and sodium intake are the primary factors that cause fluid volume imbalance and changes in body weights.
Wei-Ling Chen, Chung-Dann Kan, Chia-Hung Lin, Ying-Shin Chen, Yi-Chen Mai   +4 more
doaj   +1 more source

An Extended Stable Marriage Problem Algorithm for Clone Detection

, 2014
Code cloning negatively affects industrial software and threatens intellectual property. This paper presents a novel approach to detecting cloned software by using a bijective matching technique.
AlHakami, Hosam, Chen, Feng, Janicke, Helge   +2 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Prevention of Argentinian flag sign in intumescent cataracts using anterior chamber air bubble and cortical fluid release techniques

BMC Ophthalmology
Background To investigate the efficiency of a new method for the prevention of argentinian flag sign during the process of continuous, circular, and centered anterior capsulotomy (CCC) on the anterior capsule in cortically liquefied intumescent cataracts.
Suchang Wang, Ming Zhang, Wenwen Hou, Yan Wang, Liming Cai, Guimin Zhang   +5 more
doaj   +1 more source

Geometric design and mechanical performance of isotropic bone scaffolds

Materials & Design
Bone tissue engineering scaffolds with reduced elastic anisotropy, enhanced mechanical performance, and high ratio of surface to volume are continuous pursuits.
Rongwei Xu, Zhou Zhang, Zhen Peng, Fuyuan Deng, Zhong Li, Xu Liu, Liang He   +6 more
doaj   +1 more source