Results 51 to 60 of about 313,937 (321)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Measurement device and derivation formula for static ocular compliance

Scientific Reports
To introduce a device for measuring static ocular compliance (SOC) and propose a best-fit formula. An observational experimental study involving patients with age-related cataracts was conducted between May 2024 and September 2024.
Suchang Wang, Shancheng Si, Wenwen Hou, Ming Zhang, Guimin Zhang   +4 more
doaj   +1 more source

Geometric design and mechanical performance of isotropic bone scaffolds

Materials & Design
Bone tissue engineering scaffolds with reduced elastic anisotropy, enhanced mechanical performance, and high ratio of surface to volume are continuous pursuits.
Rongwei Xu, Zhou Zhang, Zhen Peng, Fuyuan Deng, Zhong Li, Xu Liu, Liang He   +6 more
doaj   +1 more source

Overview of building information modelling in healthcare projects [PDF]

, 2011
In this paper, we explore how BIM functionalities together with novel management concepts and methods have been utilized in thirteen hospital projects in the United States and the United Kingdom. Secondary data collection and analysis were used as the
Dave, B, Koskela, LJ, Owen, RL, Pikas, E, Sapountzis, S   +4 more
core   +1 more source

Protocols for Integrity Constraint Checking in Federated Databases [PDF]

, 1996
A federated database is comprised of multiple interconnected database systems that primarily operate independently but cooperate to a certain extent. Global integrity constraints can be very useful in federated databases, but the lack of global queries ...
Grefen, Paul, Widom, Jennifer
core   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Hardware/engineering battery-operated drills are more cost-effective as compared to orthopedic drills

Journal of Orthopaedic Diseases and Traumatology, 2019
Background: Drilling of the bone is common to produce holes for screws and pin insertion, to fix the fractured parts for immobilization. For this purpose, we need a power drill machine.
Sneh Prabhakar, Avtar Singh, Rajeev Vohra, Kanwar Kulwinder Singh, Inderdeep Singh   +4 more
doaj   +1 more source

Managing for change: August 11, 1992 v. 3, no. 5 [PDF]

, 1992
Bi-weekly newsletter of University Hospital's Change Project, provided to managers at the ...
Abercrombie, J. Scott, Jr., Boston University Medical Center, Office of Publication Services   +1 more
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Models and metaphors: complexity theory and through-life management in the built environment [PDF]

, 2008
Complexity thinking may have both modelling and metaphorical applications in the through-life management of the built environment. These two distinct approaches are examined and compared.
Allen P. M., Allen P. M., Arthur B. W., Arthur B. W., Baldwin A. N., Ballard G., Ballard G., Ballard G., Berry J. S., Bertelsen S., Bertelsen S., Bertelsen S., Bertelsen S., Bresnen M., Burke K., Button G., Button G., Carroll T., Carys Siemieniuch, Codd E. F., de Bono E., Dijkstra J., Dutton J. M., Ella-Mae Molloy, Gardner M., Garfinkel H., Garfinkel H., Gershenson C. H., Groak S., Guastello S. J., Handy C., Hofstede G., Hopp W. J., Ivory C., John Rooke, Kanter R. M., Koskela L., Koskela L., Kosko B., Lauri Koskela, Livingston E., Mike Kagioglou, Mittleton-Kelly E., Mohan Siriwardena, Morgan G., Murray Sinclair, Parsons T., Parsons T., Payr S., Peters T. J., Richardson K., Robertson D. A., Ryle G., Sacks H., Sacks H., Schutz A., Seese D., Shen W., Smallwood J., Stacey R. D., Steeb W.-H., Strauss A., Thomassen M. A., von Neumann J., Weber M., Wittgenstein L., Wolfram S.   +66 more
core   +1 more source