Results 61 to 70 of about 1,082 (240)

Customized Handmade Pulmonary Valved Conduit Reconstruction for Children and Adult Patients Using Meta-Learning Based Intelligent Model

IEEE Access, 2018
Percutaneous pulmonary valve implantation is an improved technique that is used to treat narrowed pulmonary valves or leaky pulmonary valves in patients with congenital heart disease. This technique represents a promising strategy to reduce surgical risk
Chung-Dann Kan, Wei-Ling Chen, Chia-Hung Lin, Jieh-Neng Wang, Pong-Jeu Lu, Ming-Yao Chan, Jui-Te Wu   +6 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Definição de procedimentos para levantamento de produtividade e eficiência em serviços de manutenção de equipamentos eletromédicos - EEM / [PDF]

, 1998
Dissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro ...
Rocco, Erlon de
core  

Handmade Trileaflet Valve Design and Validation for Pulmonary Valved Conduit Reconstruction Using Taguchi Method and Cascade Correlation Machine Learning Model

IEEE Access, 2018
Pulmonary valve diseases in children and adults include different degrees of stenosis, regurgitation, or congenital defects. Valve repair or replacement surgery is used to treat valvular dysfunction and to improve regurgitations flow for pulmonary valve ...
Chung-Dann Kan, Wei-Ling Chen, Chia-Hung Lin, Jieh-Neng Wang, Pong-Jeu Lu, Ming-Yao Chan, Jui-Te Wu   +6 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The framework of competency facilities manager in pre-construction hospital in Malaysia

, 2020
This paper distinguishes was conducted on the importance of the facility mnager's competence for a complex construction project such as hospital construction.
Norsyazwana Jenuwa, Misnan, Mohd. Saidin, Abdullah, Mat Naim, Mat Naim Abdullah, Jenuwa, Norsyazwana, Mohd Saidin Misnan   +5 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Maintenance Engineering in the Hospital Sector

Revista de Gestão Social e Ambiental
Objective: The objective of this study is to investigate general recommendations for service departments, aiming to improve the efficiency and quality of services provided in hospital maintenance sectors.   Theoretical Framework: This section presents the main concepts and theories that underpin the research.
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The impact of sustainable maintenance systems on government hospitals : a case of Cecilia Makewane and Frere hospitals

, 2023
This research sought to evaluate the current state of infrastructure maintenance put in place at government hospitals with a focus on Cecilia Makewane and Frere government Hospitals.
Kinama, Martin Mumo
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