Results 41 to 50 of about 310,072 (254)

Scotland Chikwawa Health Initiative - improving health from community to hospital [PDF]

, 2008
The Scotland Chikwawa Health Initiative is a three year programme funded by the Scottish Executive International Development Fund which aims to achieve measurable reductions in major causes of disease and death in four villages within the Chikwawa ...
Grimason, Anthony, Lungu, Kingsley, Makumbi, Scatter, Masangwi, Salule Joseph, Morse, Tracy, West, Peter, Womersley, John   +6 more
core  

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Measurement device and derivation formula for static ocular compliance

Scientific Reports
To introduce a device for measuring static ocular compliance (SOC) and propose a best-fit formula. An observational experimental study involving patients with age-related cataracts was conducted between May 2024 and September 2024.
Suchang Wang, Shancheng Si, Wenwen Hou, Ming Zhang, Guimin Zhang   +4 more
doaj   +1 more source

Hardware/engineering battery-operated drills are more cost-effective as compared to orthopedic drills

Journal of Orthopaedic Diseases and Traumatology, 2019
Background: Drilling of the bone is common to produce holes for screws and pin insertion, to fix the fractured parts for immobilization. For this purpose, we need a power drill machine.
Sneh Prabhakar, Avtar Singh, Rajeev Vohra, Kanwar Kulwinder Singh, Inderdeep Singh   +4 more
doaj   +1 more source

The Signal Data Explorer: A high performance Grid based signal search tool for use in distributed diagnostic applications [PDF]

, 2006
We describe a high performance Grid based signal search tool for distributed diagnostic applications developed in conjunction with Rolls-Royce plc for civil aero engine condition monitoring applications.
Austin, Jim, Fletcher, Martyn, Jackson, Tom, Jessop, Mark, Liang, Bojian   +4 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Information systems and healthcare XXIV: Factors affecting the EAI adoption in the healthcare sector [PDF]

, 2008
Recent developments in the field of integration technologies like Enterprise Application Integration (EAI) have emerged to support organizations towards improving the quality of services and reducing integration costs.
Irani, Z, Khoumbati, K, Mantzana, V, Themistocleous, M   +3 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Introductory editorial: drug-eluting stents or drug-eluting grafts? Insights from proteomic analysis [PDF]

, 2017
No abstract ...
Al-Attar, Nawwar, Coccia, Raffaella, Di Domenico, Fabio, Nappi, Francesco, Perluigi, Marzia, Spadaccio, Cristiano   +5 more
core   +1 more source