Results 91 to 100 of about 1,388,371 (309)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

A production model and maintenance planning model for the process industry [PDF]

open access: yes
In this paper a model is developed to simultaneously plan preventive maintenance and production in a process industry environment, where maintenance planning is extremely important.
Ashayeri, J., Selen, W.J., Teelen, A.
core   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

IWMI medium term plan 2010-2012 [PDF]

open access: yes
Research institutes / Strategy planning / Financial situation / Research priorities / Research projects / Project planning / Maintenance costs / Water resource management / Irrigated ...
International Water Management Institute (IWMI).
core  

Planners and the conservation of biological heritage: Implications for New Zealand and Australia [PDF]

open access: yes, 1999
The aim of this paper is to encourage greater attention by planners to conservation of native or indigenous biodiversity, and to the skills and knowledge required for this endeavour.
Jay, Grace Mairi M.
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Development and Optimization of Maintenance Using the Monte Carlo Method [PDF]

open access: yesInternational Journal of Industrial Engineering and Production Research
Maintenance plan efficacy traditionally prioritizes long-term predicted maintenance cost rates, emphasizing performance-centric approaches. However, such criteria often neglect the fluctuation in maintenance costs over renewal cycles, posing challenges ...
khamiss cheikh   +3 more
doaj  

Improving irrigation project planning and implementation processes in Sub-Saharan Africa: Diagnosis and recommendations [PDF]

open access: yes
Irrigation programs / Planning / Financing / Financial institutions / Irrigation management / Operations / Maintenance / Privatization / Cost ...
Merrey, Douglas   +3 more
core  

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

open access: yesFEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

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