Results 71 to 80 of about 3,630,524 (306)

Enhancing Railway Track Intervention Planning: Accounting for Component Interactions and Evolving Failure Risks

open access: yesInfrastructures
This manuscript proposes a methodology to leverage digitalisation to efficiently generate an overview of required condition-based railway track interventions, possession windows, and expected costs for railway networks at the beginning of the ...
Hamed Mehranfar   +3 more
doaj   +1 more source

Diversity Maintenance for Efficient Robot Path Planning

open access: yesApplied Sciences, 2020
Path planning is present in many areas, such as robotics, video games, and unmanned autonomous vehicles. In the case of robots, it is a primary low-level prerequisite for the successful execution of high-level tasks.
Petar Ćurković, Lovro Čehulić
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

open access: yesFEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil   +3 more
wiley   +1 more source

Towards a track maintenance planning tool

open access: yes, 1998
In Australian rail freight operations, track maintenance costs comprise between 25-35 percent of total train operating costs. The main aim of this paper is to describe the results of research into track maintenance planning for the medium to long-term ...
Simson, Scott   +2 more
core  

Telecommunications Network Planning and Maintenance [PDF]

open access: yes, 2008
Telecommunications network operators are on a constant challenge to provide new services which require ubiquitous broadband access. In an attempt to do so, they are faced with many problems such as the network coverage or providing the guaranteed Quality
Zorzano Mier, Francisco Javier   +3 more
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Genetic and memetic algorithms for scheduling railway maintenance activities [PDF]

open access: yes
Nowadays railway companies are confronted with high infrastructure maintenance costs. Therefore good strategies are needed to carry out these maintenance activities in a most cost effective way.
Dekker, R., Kaymak, U., Budai-Balke, G.
core  

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

Student needs, aspirations, and accomplishments: essential ingredients in state planning for postsecondary education /mpc, Master Planning Commission.

open access: yes, 1972
Cover title.; Includes bibliographical references.This report summarizes the findings of the Kansas Master Planning Commission's (mpc) inventory of the educational needs and aspirations of post high school Kansas students. Following introductory material
Kansas. Master Planning Commission.
core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

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