Results 51 to 60 of about 210,892 (267)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Fuzzy Analytical Hierarchy Process-Based Multi-Criteria Decision Framework for Risk-Informed Maintenance Prioritization of Distribution Transformers

Energies
Effective asset management is crucial for improving the reliability, resilience, and cost efficiency of distribution networks throughout the asset life cycle.
Pannathon Rodkumnerd, Thunpisit Pothinun, Suwilai Phumpho, Neville Watson, Apirat Siritaratiwat, Watcharin Srirattanawichaikul, Sirote Khunkitti   +6 more
doaj   +1 more source

Component Maintenance Planning Optimization in Defense Aviation

Aerospace, 2023
The primary objective in military aviation is to optimize operational readiness, the capability to perform assigned flight missions. This capability is influenced by aircraft downtime due to preventive maintenance at prescribed flight time intervals.
Mathijs Verhoeff, Wim J. C. Verhagen
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Enhancing Railway Track Intervention Planning: Accounting for Component Interactions and Evolving Failure Risks

Infrastructures
This manuscript proposes a methodology to leverage digitalisation to efficiently generate an overview of required condition-based railway track interventions, possession windows, and expected costs for railway networks at the beginning of the ...
Hamed Mehranfar, Bryan T. Adey, Saviz Moghtadernejad, Claudia Fecarotti   +3 more
doaj   +1 more source

Simulation-Based Analysis of Intelligent Maintenance Systems and Spare Parts Supply Chains Integration

Journal of Intelligent Systems, 2019
Production systems are composed of increasingly complex components with unique specifications. Therefore, since holding safety stocks of each component would be prohibitive, maintenance activities rely on the proper delivery of spare parts, making it ...
Frazzon Enzo M., Holtz Tulio H., Silva Lucas S., Pires Matheus C.   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Development of Indicators for Maintenance Management within Integrated Planning [PDF]

, 2017
The increased level of complexity in production and global competition demands a reliable plant capacity. To achieve this, it is of vital importance to integrate maintenance with production planning.
Rødseth, Harald
core   +1 more source

Pilot Study on the Application of Employee Scheduling for the Problem of Safety Instrumented System Design and Maintenance Planning for Remotely Located Oil and Gas Facilities

Engineering Management in Production and Services, 2018
The technology of production, transportation, and processing of oil and gas involves various hazardous processes. To mitigate the risk that these processes pose, the technological solutions work closely with the automated control and safety systems.
Redutskiy Yury
doaj   +1 more source