Results 61 to 70 of about 3,630,524 (306)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Communication-Oriented and Process Sensitive Planning Support [PDF]

, 2020
The complexity of the planning context has raised criticism against public participation for being a rigid top-down endeavour which does not recognize the different communicative needs and necessary working modes in the engagement of broad publics and ...
Staffans, Aija, Geertman, Stan, Planning Support Science, Kahila-Tani, Maarit, Horelli, Liisa, Sillanpaa, Pihla   +5 more
core   +2 more sources

Stakeholder insights for digital business model development in forest road monitoring

Frontiers in Forests and Global Change
IntroductionVital to forest management, forest roads enable operations such as timber harvesting, fire protection, and recreational access. However, their functionality is threatened by insufficient maintenance driven by limited financial and human ...
Felipe de Miguel-Díez, Felipe de Miguel-Díez, Felipe de Miguel-Díez, Ferréol Berendt, Ina Ehrhardt, Sergej Chmara, Tobias Cremer   +6 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Progress report, Nemaha County Planning Board

, 1938
"August, 1938.", Reproduced from typewritten copy.; "First of a series of publications which will be issued from time to time on subdivisional planning."--Foreword.Nemaha County Planning Board -- Foreword -- Table Of Contents -- Introduction -- General ...
Nemaha County Planning Board (Kan.)
core   +1 more source

Coding and Relationships Between Construction and Maintenance Work Units and Their Life Cycle: A Study of the Economic, Environmental and Social Sustainability of Housing in Andalusia

Applied Sciences
The holistic assessment of building life cycles requires integrating economic, environmental, and social dimensions, including occupational risks and cost management.
Diego O. Fonseca-Duarte, Ileana Berges-Alvarez, Madelyn Marrero   +2 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Assessing the Reliability of Wind-Powered EV Charging Systems in Poland Based on Long-Term Wind Data

Applied Sciences
The operational reliability of wind-powered electric vehicle charging systems (WPECS) depends not only on average wind resources but also on their temporal variability and continuity.
Magdalena Zimakowska-Laskowska, Olga Orynycz, Piotr Laskowski, Andrzej Świderski, Kamil Urbanowicz, Andrzej Wasiak, Adam Deptuła   +6 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

A production model and maintenance planning model for the process industry [PDF]

In this paper a model is developed to simultaneously plan preventive maintenance and production in a process industry environment, where maintenance planning is extremely important.
Selen, W.J., Ashayeri, J., Teelen, A.
core