Results 61 to 70 of about 210,892 (267)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

The Analysis of Natural Lighting-based Visual Comfort for Classrooms Building by Using Velux Daylight Visualizer [PDF]

open access: yesE3S Web of Conferences
This study aims to determine the level of natural lighting at a school building carried out with the use of the Velux Daylight Visualizer (VDV) software. VDV is a software for analysing natural lighting on building model.
Hajji Apif M.   +2 more
doaj   +1 more source

Development and Evaluation of Solvent-Based Cold Patching Asphalt Mixture Based on Multiscale

open access: yesAdvances in Materials Science and Engineering, 2020
In order to prepare a kind of high-performance asphalt pavement pit repair material and extend the service life of the road, this paper starts from the microscopic view of the raw materials, uses infrared spectrum, four component analysis method, lying ...
Shuolei Huang   +4 more
doaj   +1 more source

The NOx Degradation Performance of Nano-TiO2 Coating for Asphalt Pavement

open access: yesNanomaterials, 2020
The NOx degradation performance of nano-TiO2 as a coating material for the road environment was evaluated in this research. The nano-TiO2 coating materials for both road surface and roadside were prepared by using anatase nano-TiO2, activated carbon ...
Huanan Yu   +6 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Planned maintenance systems with respect to modern manufacturing strategies [PDF]

open access: yes, 1989
To remain competitive in todays's increasingly automated environment, manufacturing industry must take a more proactive and strategic attitude towards maintenance. This thesis applies these concepts, as a case study?
Quinn, Brigid Mary
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Identifying and Exploiting Features for Effective Plan Retrieval in Case-Based Planning [PDF]

open access: yes, 2015
Case-Based planning can fruitfully exploit knowledge gained by solving a large number of problems, storing the corresponding solutions in a plan library and reusing them for solving similar planning problems in the future.
Gerevini, Alfonso E.   +5 more
core   +1 more source

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