Results 111 to 120 of about 5,027,933 (297)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Strategic maintenance management : Formulating maintenance strategy

, 2015
In recent decades, by introducing lean manufacturing the vulnerability to system disturbances has increased and so, the demand for dependable production equipment. The need for having high production equipment availability causes companies to need a more
Salonen, Antti,, Rastegari, Ali,
core  

The effective maintenance strategy on the example of a company from the manufacturing industry

Nowoczesne Systemy Zarządzania
Research objectives and hypothesis/research questions Analysis of the production system in terms of the effectiveness of the maintenance strategy ear.
Natalia Zawierucha
doaj   +1 more source

Presenting a Model in Order to Appoint Maintenance Effective Strategies, Using Lean Thinking Approach [PDF]

بهبود مدیریت, 2013
In the competitive world of today, managers try to coordinate their under controlled organization with existing competitive field and with establishing the competitive benefits such as on time delivery and high quality production and decreasing the ...
Nima Rahmani, Alireza Irajpour
doaj  

Tunnel lining crack expansion and maintenance strategy optimization considering train loads: A case study. [PDF]

PLoS One, 2023
Wang D, Wang J, Rao C, Niu X, Xu Q.
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Chromatin analysis of adult pluripotent stem cells reveals a unique stemness maintenance strategy. [PDF]

Sci Adv, 2023
Poulet A, Kratkiewicz AJ, Li D, van Wolfswinkel JC.   +3 more
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Dynamic and Cost-effective Maintenance Decisions

, 2010
In general, all the elements involved in a production process, such as tools, machinery, methods, competence and working environment are exposed to changes.
Basim Al-Najjar, Niclas Eberhagen, Al-Najjar, Basim,, Eberhagen, Niclas,   +3 more
core   +1 more source