Results 111 to 120 of about 4,813,262 (294)
Chromatin analysis of adult pluripotent stem cells reveals a unique stemness maintenance strategy. [PDF]
Sci Adv, 2023 Poulet A +3 more
europepmc +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Journal of Marine Science and EngineeringThe installation and operation phases are critical stages in the lifecycle of offshore wind turbines, with costs associated with the installation and maintenance of floating wind turbines accounting for approximately 50% of the total investment.
Mingfeng Hu +5 more
doaj +1 more source
Optimal Maintenance Policy for a Markov Deteriorating System Under Reliability Limit
In this study, failure data of computer numerical control machine used in defense industry was analyzed to develop maintenance algorithm with a Markov feature. An imperfect preventive maintenance model that minimizes long-term operational cost is created
Khaniyev, Tahir, Ozturk, Meltem Kocer
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Research on Reliability Evaluation Method of Metro Signal System
机车电传动, 2018 The reliability of metro signal system is the decisive factor to ensure the safety, availability and maintainability. Aiming at the lack of signal system RAMS evaluation methods, based on vector data model and statistics analysis methods, CBTC interlock ...
MO Zhigang, LUO Hanbin
doaj
Chengshi guidao jiaotong yanjiu［Objective］ The pressure air dryness at the metro vehicle air compressor outlet is a very important indicator. If the water content in the pressure air is high, it will affect the performance of various air-using equipment, and thus affect driving safety.
LI Jianxing, LI Huaizhi
doaj +1 more source
Analysis of maintenance strategies
, 1998 The most nuclear power utilities have established goals and objectives for their nuclear power plants, including e.g. 1) operating the plant effectively from primarily the safety and secondly the economic point of view, 2) ensuring safety of the public and the plant workers, and 3) providing uninterrupted electric power to the shareholders with long ...
Laakso, Kari, Simola, Kaisa
+5 more sources
Is telerehabilitation an effective maintenance strategy for patients with chronic obstructive pulmonary diseases: a systematic review. [PDF]
Bull Natl Res Cent, 2023 Uche-Okoye D +8 more
europepmc +1 more source