Results 131 to 140 of about 5,027,933 (297)

Software Product Support and Maintenance Outsourcing Prepared By EXECUTIVE SUMMARY

, 2008
4 72%: percentage of software product companies who will release a new product each year 4 9 months: s/w product life cycle 4 < 10%: success rate of new products 4 60%: average percentage of maintenance costs to the total cost in the product life ...
Goldstone Technologies, Maintenance Outsourcing   +1 more
core  

Fuzzy Risk-Based Maintenance Strategy with Safety Considerations for the Mining Industry. [PDF]

Sensors (Basel), 2022
Tubis A, Werbińska-Wojciechowska S, Sliwinski P, Zimroz R.   +3 more
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Opportunistic Maintenance Strategy for Complex Equipment with a Genetic Algorithm Considering Failure Dependence: A Two-Dimensional Warranty Perspective. [PDF]

Sensors (Basel), 2022
Dong E, Gao T, Cheng Z, Wang R, Bai Y.
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Organic Farming as an Alternative Maintenance Strategy in the Opinion of Farmers from Natura 2000 Areas. [PDF]

Int J Environ Res Public Health, 2022
Pawlewicz A, Gotkiewicz W, Brodzińska K, Pawlewicz K, Mickiewicz B, Kluczek P.   +5 more
europepmc   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Dolutegravir Monotherapy as Maintenance Strategy: A Meta-Analysis of Individual Participant Data From Randomized Controlled Trials. [PDF]

Open Forum Infect Dis, 2022
Fournier AL, Hocqueloux L, Braun DL, Metzner KJ, Kouyos RD, Raffi F, Briant AR, Martinez E, De Lazzari E, Negredo E, Rijnders B, Rokx C, Günthard HF, Parienti JJ.   +13 more
europepmc   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

A risk evaluation framework for the best maintenance strategy: The case of a marine salt manufacture firm. [PDF]

Reliab Eng Syst Saf, 2021
Carpitella S, Mzougui I, Benítez J, Carpitella F, Certa A, Izquierdo J, La Cascia M.   +6 more
europepmc   +1 more source