Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Dolutegravir Monotherapy as Maintenance Strategy: A Meta-Analysis of Individual Participant Data From Randomized Controlled Trials. [PDF]
Open Forum Infect Dis, 2022 Fournier AL +13 more
europepmc +1 more source
National Tourism Strategy 2013-2018 [PDF]
, 2013 This National Tourism Strategy is a culmination of extensive stakeholder involvement and participation. It is also a fulfillment of the Tourism Act 2011, Section 3.
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Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
A risk evaluation framework for the best maintenance strategy: The case of a marine salt manufacture firm. [PDF]
Reliab Eng Syst Saf, 2021 Carpitella S +6 more
europepmc +1 more source
Determination of optimal preventive maintenance strategy for serial production lines
, 2008 A Split System Approach (SSA) based methodology is presented to assist in making optimal Preventive\ud Maintenance decisions for serial production lines. The methodology treats a production line as a\ud complex series system with multiple PM actions over
Mathew, Joseph, Sun, Yong, Ma, Lin
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Kenya Community Health Strategy 2020-2025
, 2020 The Kenya Community Health Strategy 2020 – 2025 (KCHS 2020 – 2025) was developed to build on the Community Health Strategy 2014 – 2019. The development of the KCHS 2020 – 2025 is based on the lessons learnt from the implementation of the Community Health
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Optimal Maintenance Strategy for First-Line Oxaliplatin-Containing Therapy with or without Bevacizumab in Patients with Metastatic Colorectal Cancer: A Meta-Analysis. [PDF]
Cancer Res Treat, 2021 Moriwaki T +5 more
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