Results 141 to 150 of about 552,138 (306)

Development of a Cost Optimal Predictive Maintenance Strategy

Maintenance costs account for a significant share of operating expenses. Selecting the optimal maintenance strategy for each application is crucial to optimize operational processes and minimize MRO spending.
Weeber, Christoph
core   +2 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Enterprise level maintenance strategy selection an empirical model

, 2009
Maintenance plays a significant role in increasing the overall profit of an organization. However, the lack of efficient maintenance strategy selection procedures causes the operating costs to increase thereby decreasing the organizational profit.
Amalesh, Joseph Virgil
core   +1 more source

Optimal Maintenance Strategy for First-Line Oxaliplatin-Containing Therapy with or without Bevacizumab in Patients with Metastatic Colorectal Cancer: A Meta-Analysis. [PDF]

Cancer Res Treat, 2021
Moriwaki T, Gosho M, Sugaya A, Yamada T, Yamamoto Y, Hyodo I.   +5 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Maintenance Strategy Evaluation Using ANP and Goal Programming

, 2011
An optimal maintenance strategy mix is necessary for increasing availability and reliability levels of production facilities without significantly increasing operational costs.
Sarojini Jajimoggala, V. V. S. Kesava Rao, Beela Satyanarayana   +2 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Selection of maintenance strategy, using analytical hierarchy process [Elektronisk resurs]

, 2009
Selection of appropriate maintenance strategy is key to economic viability of aviation and manufacturing industries. The study discusses and presents an approach to facilitate the selection of the most appropriate maintenance strategy on the basis of the
Kumar, Uday, Ahmadi, Alireza,, Schunnesson, Håkan, Arasteh Khouy, Iman   +3 more
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Optimisation of bridge maintenance strategy and cost considering whole life costs and carbon emissions

This paper describes the optimisation of bridge maintenance strategy and cost, utilising a Structures Asset Valuation and Investment (SAVI) tool and considering whole life costs, traffic delays and carbon emissions arising from the bridge maintenance ...
Omer, Joshua
core   +1 more source