Results 151 to 160 of about 4,813,262 (294)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Integrative maintenance strategy

, 2013
A globalização catapultou a competição entre empresas para um nível mundial, onde estas lutam pela sobrevivência quer com os seus concorrentes, quer entre diversas unidades de uma mesma empresa espalhada pelo planeta. Com cada vez mais opções à escolha, os clientes como dominantes nesta competição, exigem cada vez mais qualidade e rapidez às ...
openaire   +1 more source

Choosing the optimal maintenance strategy in multiple myeloma. [PDF]

Hematology Am Soc Hematol Educ Program
Puliafito B, Cirstea D, Raje N.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Rosai-Dorfman-Destombes Disease With CNS Involvement: From Treatment Response to Maintenance Strategy and Insights Into Systemic Inflammatory Dysregulation. [PDF]

Cureus
El Amani M, Haidouri S, Youssef M, Benlachgar N, Tazi Mezalek Z.   +4 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Risk-sensitive joint inventory-maintenance strategy for bearing health management under prognostic uncertainty: an uncertainty-aware deep reinforcement learning approach. [PDF]

Sci Rep
Zhang Z, Shen N, Wang X.
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Deep reinforcement learning-driven multi-objective optimization and its applications on lighting infrastructure operation and maintenance strategy. [PDF]

Sci Rep
Wang Z, Tang J, Wei P, Lun W, Wang Y, Yang W, Xiao H.   +6 more
europepmc   +1 more source

A prospective observational study on the optimal maintenance strategy in HER2-positive advanced gastric cancer treated with trastuzumab-based therapy. [PDF]

J Cancer Res Clin Oncol, 2020
Li Q, Lv M, Jiang H, Wang Y, Yu S, Li W, Yu Y, Liu T.   +7 more
europepmc   +1 more source