Results 111 to 120 of about 652,724 (310)

IMWG consensus on maintenance therapy in multiple myeloma

, 2012
Maintaining results of successful induction therapy is an important goal in multiple myeloma. Here, members of the International Myeloma Working Group review the relevant data.
McCarthy, Philip, Facon, Thierry, Richardson, Paul G, Hulin, Cyrille, Sonneveld, Pieter, Wijermans, Pierre, San Miguel, Jésus, Palumbo, Antonio, Ludwig, Heinz, Waage, Anders, Morgan, Gareth, Einsele, Hermann, Stewart, Keith A, International Myeloma Working Group, Barlogie, Bart, Beksac, Meral, Andersen, Kenneth C, Attal, Michel, Landgren, Ola, Orlowski, Robert, Mateos, Maria-Victoria, Niesvizky, Ruben, Lokhorst, Henk, Bergsagel, P Leif, Hinke, Axel, Durie, Brian G M, Spencer, Andrew, Landgren, Carl, Cavo, Michele   +28 more
core   +3 more sources

Maintenance therapy in COPD: time to phase out ICS and switch to the new LAMA/LABA inhalers?

, 2017
Syed Mohammad Tariq,1 Enson C Thomas2 1Department of Respiratory Medicine, Luton and Dunstable University Hospital, Luton, 2Respiratory Unit, Bedford Hospital, Bedford, UK Abstract: Long-term maintenance therapy for COPD is evolving rapidly.
Thomas EC, Tariq SM
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Patterns of 6-mercaptopurine and azathioprine maintenance therapy among a cohort of commercially insured individuals diagnosed with Crohn's disease in the United States

, 2013
Jennifer L Lund,1 Suzanne F Cook,2 Jeffery K Allen,2 Charlotte F Carroll,2 Michael D Kappelman3 1Department of Clinical Epidemiology, Aarhus University, Aarhus, Denmark; 2Worldwide Epidemiology, GlaxoSmithKline, Research Triangle Park, NC, USA ...
Carroll CF, Cook SF, Kappelman MD, Allen JK, Lund JL   +4 more
core  

Paediatric Crohn's Disease: The Impact of First Maintenance Therapy

, 2023
Background: Tumour necrosis factor-a antagonist (aTNF) therapy is increasingly used as primary therapy to induce and/or maintain remission of Crohn’s disease (CD).
Schneider, Rilla
core  

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Initiation of triple therapy maintenance treatment among patients with COPD in the US

, 2016
Jason C Simeone,1 Rakesh Luthra,2 Shuchita Kaila,2 Xiaoyun Pan,1 Tarun D Bhagnani,1 Jieruo Liu,1 Teresa K Wilcox1 1Real-World Evidence, Evidera, Waltham, MA, 2HEOR Value Demonstration Team, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA
Pan X, Liu J, Bhagnani TD, Wilcox TK, Kaila S, Simeone JC, Luthra R   +6 more
core  

Preference for On-Demand Fexuprazan Therapy in Gastroesophageal Reflux Disease: A Prospective Cohort Study

Introduction: Maintenance therapy is crucial in managing and preventing symptom relapse in gastroesophageal reflux disease (GERD), with continuous and on-demand therapy being the common approaches. However, maintenance therapy using potassium-competitive
Chang Soo Eun, Byung Wook Jung, Chan Hyuk Park   +2 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source