Results 91 to 100 of about 652,724 (310)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Immunosuppressive therapy for kidney transplantation in adults: a systematic review and economic model

Health Technology Assessment, 2016
Background: End-stage renal disease is a long-term irreversible decline in kidney function requiring renal replacement therapy: kidney transplantation, haemodialysis or peritoneal dialysis.
Tracey Jones-Hughes, Tristan Snowsill, Marcela Haasova, Helen Coelho, Louise Crathorne, Chris Cooper, Ruben Mujica-Mota, Jaime Peters, Jo Varley-Campbell, Nicola Huxley, Jason Moore, Matt Allwood, Jenny Lowe, Chris Hyde, Martin Hoyle, Mary Bond, Rob Anderson   +16 more
doaj   +1 more source

Continuation and maintenance therapy in depression [PDF]

British Medical Bulletin, 2001
AbstractThis paper reviews longer term treatment for unipolar depression. Antidepressant continuation for prevention of early relapse has been routine for many years. Recent evidence supports a longer period of 9 months to 1 year after remission. Antidepressants are also effective in maintenance treatment for recurrent depression, and are indicated ...
openaire   +2 more sources

6-thioguanine treatment in inflammatory bowel disease: A critical appraisal by a European 6-TG working party [PDF]

, 2006
Recently, the suggestion to use 6-thioguanine (6-TG) as an alternative thiopurine in patients with inflammatory bowel disease (IBD) has been discarded due to reports about possible (hepato) toxicity. During meetings arranged in Vienna and Prague in 2004,
Seiderer, J., Merwe, S. W. van der, Ochsenkühn, Thomas, Almer, S., Petritsch, W, Mulder, C. J. J, Seiderer, J, Vogelsang, H., Mulder, CJJ, Teml, A, Van Bodegraven, A. A., Teml, A., Herrlinger, K. R., Schwab, M., de Boer, NKH, Knoflach, P, van der Merwe, SW, Schwab, M, Reinisch, W., Ochsenkuhn, T, Reinisch, W, Knoflach, P., Petritsch, W., De Boer, N. K.H., De Boer, N. K. H, Van Der Merwe, S. W., Almer, Sven,, Vogelsang, H, Lukas, M., Ochsenkühn, T., van Bodegraven, AA, Lukas, M, Herrlinger, KR, Mulder, C. J.J., Bodegraven, A. A. van   +34 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The Evolving Role of Maintenance Therapy Using Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors (EGFR TKIs) in the Management of Advanced Non-Small-Cell Lung Cancer

, 2012
The epidermal growth factor receptor (EGFR) plays an important role in the development of many cancers, including non-small cell lung cancer. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) are a class of novel biologically ...
Benjamin C. Powers, Chao H. Huang
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Targeted Drugs as Maintenance Therapy after Autologous Stem Cell Transplantation in Patients with Mantle Cell Lymphoma

Pharmaceuticals, 2017
The treatment landscape for mantle cell lymphoma (MCL) is rapidly evolving toward the incorporation of novel and biologically targeted pharmaceuticals with improved disease activity and gentler toxicity profiles compared with conventional ...
Fengting Yan, Ajay K. Gopal, Solomon A. Graf   +2 more
doaj   +1 more source

Impact on life expectancy of HIV-1 positive individuals of CD4+ cell count and viral load response to antiretroviral therapy. [PDF]

, 2014
The objective of this study is to estimate life expectancies of HIV-positive patients conditional on response to antiretroviral therapy (ART)
Richard Gilson, Margaret T. May, John Walsh, Chadwick, D, Gompels, Mark, Porter, Kholoud, Anderson, Jane, Delpech, V, UK, UKCHIVC, Leen, Clifford, Martin, F, Valerie Delpech, Sophie Jose, Hill, Teresa, Jose, Sophie, Pillay, Deenan, Sabin, Caroline, Chloe Orkin, Orkin, Chloe, Fabiola Martin, UK Collaborative HIV Cohort (UK CHIC) Study, ., Sabin, C, Hay, Phillip, Johnson, M, Martin Fisher, Gilson, Richard, Kholoud Porter, Fisher, M, Ainsworth, Jonathan, ?, ?, Johnson, Margaret, Gilson, R, Hay, P, Gompels, M, Phillip Hay, Nelson, Mark, Palfreeman, Adrian, Teresa Hill, Phillips, Andrew, Mackie, Nicky, Porter, K, May, Margaret T, Delpech, Valerie, Mark Nelson, UK Collaborative HIV Cohort (UK CHIC) Study, Fisher, Martin, Walsh, J, Babiker, Abdel, Hill, T, Schwenk, Achim, Adrian Palfreeman, Chadwick, David, Orkin, C, Winston, Alan, Ainsworth, J, Kegg, Stephen, Margaret Johnson, David Chadwick, Caroline Sabin, Walsh, John, Sachikonye, Memory, Nelson, M, Kegg, S, May, MT, Frank Post, Clifford Leen, Martin, Fabiola, Dunn, Daviad, Anderson, J, Gazzard, Brian, Post, Frank, Mark Gompels, Jose, S, May, Margaret T., Post, F, Palfreeman, A, Leen, C, Stephen Kegg, Jonathan Ainsworth, Jane Anderson   +79 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source