Results 81 to 90 of about 652,724 (310)
Factors Influencing the Duration of Maintenance Therapy in Metastatic Colorectal Cancer
Background/Objectives: Metastatic colorectal cancer (mCRC) is mainly treated with 5-Fluoro-Uracil (5-FU), Oxaliplatin and Irinotecan chemotherapies and anti-Epidermal Growth Factor Receptor (EGFR) or anti-Vascular Endothelial Growth Factor (VEGF ...
Rémi Palmier +10 more
core +1 more source
Maintenance therapy in multiple myeloma
, 2009 The treatment of multiple myeloma (MM) has changed dramatically in the past twenty years with the introduction of high-dose therapy plus autologous stem-cell transplantation (ASCT) in younger patients and, more recently, of three novel agents ...
Jean-Luc Harousseau
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
مجله علوم روانشناختی, 2022 Background: Substance abuse is one of the most important causes of risky behavior and its detrimental effect on other social harms is tangible and takes up a substantial amount of funds and resources.
Mahsa Kashefizadeh +3 more
doaj
Case Reports in Oncology, 2020 Leiomyosarcomas of the lower extremity are extremely rare disorders and account for 10–15% of limb soft tissue sarcomas. These tumours have poor prognosis and even in early stages, patients persist at high risk for local and distant relapse; consequently,
Magda Cordeiro +6 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
, 2017 Liangzhe Zhang, Shugeng Gao, Jie He Department of Thoracic Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China Purpose: Maintenance therapy is an effective treatment ...
He J, Zhang L, Gao S
core
Cytokines in hepatitis C-infected patients with or without opioid maintenance therapy [PDF]
Objective: Both chronic hepatitis C virus (HCV) infection and opioids cause altered blood levels of cytokines. Previous studies have investigated levels of selected groups of cytokines in patients on opioid maintenance treatment.
Bramness, Jørgen Gustav +7 more
core +1 more source
Rational and safe dosing of phenprocoumon during loading and maintenance phase [PDF]
, 2012 Phenprocoumon is the second most commonly used oral anticoagulant worldwide and the most common agent in many European countries including Switzerland. Given its long half-life of about one week, an initial loading-dose is generally applied. A high
Caduff Good, Angela
core +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source