Results 71 to 80 of about 652,724 (310)

Effect of Age on Outcome of High-Risk Non-Muscle-Invasive Bladder Cancer Patients Treated with Second Transurethral Resection and Maintenance Bacillus Calmette-Guerin Therapy

, 2016
Objective To determine the effect of age on recurrence and progression rates in a population of high-risk non-muscle invasive bladder cancer (NMIBC) patients treated with a second transurethral resection (TUR) and at least 1 year of maintenance Bacillus
Sümer Baltacı, Mehmet İlker Gökçe, Murat Bozlu, Cavit Can, Aydın Mungan, Asıf Yıldırım, Güven Aslan, İlker Tinay, Uğur Kuyumcuoğlu, Levent Türkeri   +9 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Desmoplastic small round cell tumors: Multimodality treatment and new risk factors

Cancer Medicine, 2019
Background To evaluate optimal therapy and potential risk factors. Methods Data of DSRCT patients
Monika Scheer, Christian Vokuhl, Bernd Blank, Erika Hallmen, Thekla von Kalle, Marc Münter, Rüdiger Wessalowski, Maite Hartwig, Monika Sparber‐Sauer, Paul‐Gerhardt Schlegel, Christof M. Kramm, Udo Kontny, Bernd Spriewald, Thomas Kegel, Sebastian Bauer, Bernarda Kazanowska, Felix Niggli, Ruth Ladenstein, Gustaf Ljungman, Kirsi Jahnukainen, Jörg Fuchs, Stefan S. Bielack, Thomas Klingebiel, Ewa Koscielniak, the Cooperative Weichteilsarkom Studiengruppe [CWS]   +24 more
doaj   +1 more source

Maintenance cognitive stimulation therapy for dementia: single-blind, multicentre, pragmatic randomised controlled trial

, 2014
Background There is good evidence for the benefits of short-term cognitive stimulation therapy for dementia but little is known about possible long-term effects.
Woods, Robert T., Orrell, Martin, Russell, I., Aguirre, Elisa, Russell, Ian, Hoe, Juanita, Woods, R.T., Spector, A., Hoare, Zoe, Streater, A., Knapp, Martin, Knapp, M., Donovan, H., Hoe, J., Whitaker, C., Donovan, Helen, Aguirre, E., Orrell, M., Spector, Aimee, Streater, Amy, Hoare, Z., Whitaker, Christopher   +21 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A Retrospective Exploration of Targeted Maintenance Therapy in Advanced Colorectal Cancer: Based on the Background of Chinese Patient Assistance Program

Frontiers in Oncology, 2020
Background: Maintenance therapy with bevacizumab (Bev) in patients with colorectal cancer (CRC) provides progression-free survival (PFS) benefits. However, the role of maintenance therapy with an anti-EGFR monoclonal antibody has not been established ...
Hanguang Hu, Xue Liu, Wen Cai, Dehao Wu, Junxi Xu, Ying Yuan, Ying Yuan   +6 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Comparative efficacy of targeted maintenance therapy for newly diagnosed epithelial ovarian cancer: a network meta-analysis

, 2019
Xiaoyu Xu,1 Songcheng Yin,2,3 Hongling Guo,1 Mengxiong Li,1 Zhirong Qian,4 Xiaohui Tian,1 Tian Li11Department of Gynecology, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, People’s Republic of China; 2Center for Digestive ...
Qian Z, Li T, Yin S, Guo H, Tian X, Xu X, Li M   +6 more
core  

Prolonged lenalidomide maintenance therapy improves the depth of response in multiple myeloma

, 2020
Lenalidomide is an immunomodulatory drug approved for maintenance treatment in newly diagnosed multiple myeloma, and it has been shown to improve progression-free survival (PFS) and, in several studies, overall survival.
Alonso, Rafael, Valeri, Antonio, Martínez López, Joaquín, Cedena, María Teresa, Collado Yurrita, Luis Rodolfo, García, Cristina, Sánchez, Ricardo, Lahuerta Palacios, Juan José   +7 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source