Results 31 to 40 of about 1,638 (186)

Matching strategy for patients with platelet transfusion refractoriness caused by compound antibodies against HLA and CD36

Zhongguo shuxue zazhi, 2023
Objective To search compatible and suitable platelets for platelet transfusion refractoriness (PTR) patient caused by compound antibodies against HLA and CD36.
Jing DENG, Xiuzhang XU, Huibin ZHONG, Bi ZHONG, Yangkai CHEN, Jing LIU, Haoqiang DING, Wenjie XIA, Dawei CHEN, Yaori XU, Xin YE   +10 more
doaj   +1 more source

Immobilized Enzymes for ABO-Independent Blood Cell Transfusions. [PDF]

Chembiochem
A method is developed to generate universal red blood cells and platelets using suitable glycosidases immobilized to polymethacrylate microparticles. This approach allows the efficient removal of the enzymes converting the A and B antigens before transfusion to avoid immune reactions and illustrates a promising method to counteract the demand for blood
Möller C, Pohlschröder F, Wesche J, Schmiade P, Baselau M, Wende K, Stloukalová B, Böttcher D, Greinacher A, Bornscheuer UT, Terholsen H, Aurich K.   +11 more
europepmc   +2 more sources

Course of immune thrombocytopenia according to the site of platelet destruction identified by indium-111 platelet scintigraphy. [PDF]

Br J Haematol
In primary immune thrombocytopenia (ITP), predictors of disease evolution and treatment response are needed. Data based on the site of platelet destruction are scarce, yet Indium‐111 platelet scintigraphy (IPS) could be helpful to help physicians in choosing specific treatments.
Durand P, Pottier V, Debordeaux F, Mesguich C, Duffau P, Lazaro E, Viallard JF, Rivière E.   +7 more
europepmc   +2 more sources

DESAFIOS NO DIAGNÓSTICO E MANEJO DE REFRATARIEDADE PLAQUETÁRIA NO TRANSPLANTE ALOGÊNICO DE CÉLULAS PROGENITORAS ‒ RELATO DE CASO

Hematology, Transfusion and Cell Therapy, 2023
Introdução: A formação de anticorpos anti-HLA decorre de gravidez ou transfusão e pode acarretar baixo incremento após as transfusões de plaquetas.
TFN Araújo, ML Puls, BA Souza, CFM Ferreira, LFS Dias, MC Mendonça, FS Ghaname, S Wendel, R Fontão-Wendel, C Almeida-Neto   +9 more
doaj   +1 more source

Heterodimeric Protein Surface‐Coupling Platform: Immobilization of Conformation Switchable and Functional αIIbβ3 Integrin

Advanced Materials Interfaces, Volume 10, Issue 35, December 13, 2023., 2023
A novel biomimetic‐platform for covalent and site‐directed immobilization of oriented αIIbβ3 integrin heterodimers onto hydroxyl bearing surfaces, as with cell surface integrins, immobilized αIIbβ3 can be modulated to the active ligand‐binding conformation by divalent cations.
Miguel A. D. Neves, Sladjana Slavkovic, Yiming Wang, Yfke Pasman, Aron A. Shoara, Reid C. Gallant, Guangheng Zhu, Pasquale Benvenuto, Philip E. Johnson, Michael Thompson, Heyu Ni   +10 more
wiley   +1 more source

B cells and antibodies in refractory immune thrombocytopenia

British Journal of Haematology, Volume 203, Issue 1, Page 43-53, October 2023., 2023
Summary Immune thrombocytopenia (ITP) is an acquired bleeding disorder mediated by pathogenic autoantibodies secreted by plasma cells (PCs) in many patients. In refractory ITP patients, the persistence of splenic and bone marrow autoreactive long‐lived PCs (LLPCs) may explain primary failure of rituximab and splenectomy respectively.
Anaïs Roeser, Alan H. Lazarus, Matthieu Mahévas   +2 more
wiley   +1 more source

European Management of Glanzmann's Thrombasthenia: A Survey of Current Clinical Practice. [PDF]

Haemophilia
ABSTRACT Introduction Glanzmann's thrombasthenia is a rare inherited platelet disorder characterized by a lack of platelet aggregation. Patients tend to be diagnosed in early childhood with treatment strategies involving a multifaceted approach to prevent and manage bleeding episodes.
Fiore M, Artoni A, Klamroth R, Mathias M, Schutgens R, d'Oiron R, EAHAD Glanzmann Thrombasthenia Working Group.   +6 more
europepmc   +2 more sources

Fetal and neonatal alloimmune thrombocytopenia: No evidence of systemic inflammation as a modulator of disease severity. Could placental inflammation be key?

British Journal of Haematology, Volume 203, Issue 2, Page 304-310, October 2023., 2023
Summary In fetal/neonatal alloimmune thrombocytopenia (FNAIT), maternal alloantibodies against paternal human platelet antigens (HPA) cross the placenta and lead to platelet destruction. The extent of thrombocytopenia varies among neonates, and inflammation may constitute an important trigger.
David Böhm, Sandra Wienzek‐Lischka, Nina Cooper, Heike Berghöfer, Katja Müller, Behnaz Bayat, Gregor Bein, Ulrich J. Sachs   +7 more
wiley   +1 more source

Markers of refractory primary immune thrombocytopenia

British Journal of Haematology, Volume 203, Issue 1, Page 112-118, October 2023., 2023
Evidence‐based markers of refractoriness to ‘second‐line’ marketed ITP treatments. ITP, immune thrombocytopenia; TPO, thrombopoietin. TPO‐RA, thrombopoietin receptor agonist. Summary Refractory immune thrombocytopenia (ITP) is a challenging disease that can be defined by refractoriness to second‐line treatments.
Guillaume Moulis, Lamya Garabet
wiley   +1 more source

Accessory spleens recapitulate the immune microenvironment of the main spleen in immune thrombocytopenia

British Journal of Haematology, Volume 202, Issue 1, Page 147-152, July 2023., 2023
Summary Accessory spleens (AcS) may play a relevant role in immune thrombocytopenia (ITP) and possibly contribute to ITP relapse following splenectomy. Little is known about the immune microenvironment of AcS in ITP. To address this issue, we compared the histological features of eight matched AcS and main spleen (MS) samples, obtained from adult ...
Marco Pizzi, Fabrizio Vianello, Luisa Lorenzi, Gianni Binotto, Marta Sbaraglia, Federico Scarmozzino, Andrea De Crescenzo, Vincenza Guzzardo, Simone Zoletto, Fabio d'Amore, Alberto Friziero, Mariella D'Adda, Fabio Facchetti, Angelo Paolo Dei Tos   +13 more
wiley   +1 more source