Results 141 to 150 of about 332 (158)
Some of the next articles are maybe not open access.
Maitotoxin, a cationic channel activator.
Neurobiology (Budapest, Hungary), 1998Maitotoxin (MTX), a water soluble polyether obtained from the marine dinoflagellate Gambierdiscus toxicus is one of the entities responsible for Ciguatera, a form of seafood poisoning. This toxin is a potent activator of changes in the intracellular Ca2+ concentrations of cells from a wide variety of organisms.
L I, Escobar +3 more
openaire +1 more source
Maitotoxin-induced Free Ca Changes in Single Rat Hepatocytes
Cellular Signalling, 1999We report the results using bioluminescent and fluorescent indicators to investigate maitotoxin-induced free Ca changes in single rat hepatocytes. Maitotoxin generated a steadily rising free Ca increase after a long lag period. The free Ca increase was dependent on extracellular calcium and could be antagonised by chelation of extracellular calcium or ...
N M, Woods +4 more
openaire +2 more sources
Chemical Synthesis of the GHIJKLMNO Ring System of Maitotoxin
Journal of the American Chemical Society, 2008As the largest secondary metabolite to be discovered as of yet, the polyether marine neurotoxin maitotoxin constitutes a major structural and synthetic challenge. After its originally proposed structure ( 1) had been questioned on the basis of biosynthetic considerations, we provided computational and experimental support for structure 1.
K C, Nicolaou +9 more
openaire +2 more sources
Dopamine inhibits maitotoxin-stimulated pituitary 45Ca2+ efflux and prolactin release
American Journal of Physiology-Endocrinology and Metabolism, 1986We examined the hypothesis that dopaminergic inhibition of prolactin release is coupled to modulation of cellular calcium flux. Dispersed female rat pituitary cells were prelabeled in 45Ca2+ and perifused to determine simultaneously fractional calcium efflux and prolactin release, as stimulated by maitotoxin, a calcium channel activator. The integrated
I S, Login, A M, Judd, R M, MacLeod
openaire +2 more sources
Ca2+ channel activating action of maitotoxin in cultured brainstem neurons
European Journal of Pharmacology, 2006The actions of maitotoxin were studied using cultured brainstem cells and adrenal chromaffin cells. Maitotoxin induced a profound increase in the Ca2+ influx into cultured brainstem cells after a brief lag period. The maitotoxin-induced Ca2+ influx was suppressed by various voltage-dependent Ca2+ channel blockers such as Co2+, Mn2+, verapamil and ...
Atsushi, Kakizaki +7 more
openaire +2 more sources
On the Structure of Maitotoxin
Angewandte Chemie International Edition, 2007K C, Nicolaou, Michael O, Frederick
openaire +2 more sources