Results 121 to 130 of about 267 (149)

Maitotoxin-induced membrane current in neuroblastoma cells

Brain Research, 1987
Maitotoxin (MTX) is a potent marine toxin isolated from the toxic dinoflagellate, Gambierdiscus toxicus. We have examined the possibility of MTX activating calcium channels using cultured neuroblastoma cells (N1E-115). MTX (10 ng/ml) produced a depolarization of the membrane, which was prevented by the removal of Ca2+ from the external medium.
M, Yoshii, A, Tsunoo, Y, Kuroda, C H, Wu, T, Narahashi   +4 more
openaire   +2 more sources

Selective stimulation of Ca2+ flux in cells by maitotoxin

European Journal of Pharmacology: Molecular Pharmacology, 1992
Maitotoxin elicits a dose-dependent stimulation of 45Ca2+ influx in glioma C6, pheochromocytoma PC12, insulinoma HIT and human blood cells, while having no effect in liposomes. In HIT cells maitotoxin also elicited influx of 86Rb+ greater than 22Na+ greater than 54Mn2+, but the stimulation was far less than for 45Ca2+.
M, Murata, F, Gusovsky, T, Yasumoto, J W, Daly   +3 more
openaire   +2 more sources

Chemical Synthesis of the GHIJKLMNO Ring System of Maitotoxin

Journal of the American Chemical Society, 2008
As the largest secondary metabolite to be discovered as of yet, the polyether marine neurotoxin maitotoxin constitutes a major structural and synthetic challenge. After its originally proposed structure ( 1) had been questioned on the basis of biosynthetic considerations, we provided computational and experimental support for structure 1.
K C, Nicolaou, Michael O, Frederick, Antonio C B, Burtoloso, Ross M, Denton, Fatima, Rivas, Kevin P, Cole, Robert J, Aversa, Romelo, Gibe, Taiki, Umezawa, Takahiro, Suzuki   +9 more
openaire   +2 more sources

ChemInform Abstract: Maitotoxin — An Inspiration for Synthesis

ChemInform, 2011
AbstractReview: 220 refs.
K. C. Nicolaou, Robert J. Aversa
openaire   +1 more source

Maitotoxin, a cationic channel activator.

Neurobiology (Budapest, Hungary), 1998
Maitotoxin (MTX), a water soluble polyether obtained from the marine dinoflagellate Gambierdiscus toxicus is one of the entities responsible for Ciguatera, a form of seafood poisoning. This toxin is a potent activator of changes in the intracellular Ca2+ concentrations of cells from a wide variety of organisms.
L I, Escobar, C, Salvador, M, Martínez, L, Vaca   +3 more
openaire   +1 more source

Antibodies to maitotoxin elicited by immunization with toxin-fragment conjugates

Toxicon, 1996
Maitotoxin is a water-soluble polyether toxin produced by the benthic dinoflagellate, Gambierdiscus toxicus. Toxin fragments generated by periodate oxidation were conjugated to keyhole limpet hemocyanin, and the resulting immunogens were used to elicit maitotoxin-specific antibodies in mice.
G S, Bignami, D F, Waller, T, Yasumoto
openaire   +2 more sources

Maitotoxin

2022
Jaspreet Kaur, Sukriti Singh, Arashdeep Singh   +2 more
openaire   +1 more source

ChemInform Abstract: Complete Structure of Maitotoxin

ChemInform, 1998
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
openaire   +1 more source

On the Structure of Maitotoxin

Angewandte Chemie International Edition, 2007
K C, Nicolaou, Michael O, Frederick
openaire   +2 more sources

Synthesis of the WXYZA'B'C'D'E'F' Ring of Maitotoxin

Journal of Synthetic Organic Chemistry, Japan, 2023
Keitaro Umeno, Tohru Oishi
openaire   +1 more source