Results 111 to 120 of about 267 (149)
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Activation of calcium channels by Maitotoxin
1987Publisher Summary This chapter describes three techniques that enhance the understanding of the action of maitotoxin by using 45Ca2+ to monitor calcium ion flux. The techniques are not new but are adapted for use with viable dispersed anterior pituitary cells in suspension.
I S, Login, A M, Judd, R M, MacLeod
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Chemical Diversity, Origin, and Analysis of Phycotoxins [PDF]
Journal of Natural Products, 2016 Microalgae, particularly those from the lineage Dinoflagellata, are very well-known for their ability to produce phycotoxins that may accumulate in the marine food chain and eventually cause poisoning in humans.
Silas Rasmussen +2 more
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ChemInform Abstract: Structure of Maitotoxin
ChemInform, 1993AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
M. MURATA +6 more
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Complete Relative Stereochemistry of Maitotoxin
Journal of the American Chemical Society, 1996By addressing the relative stereochemistry of the four acyclic portions via organic synthesis, the complete relative stereochemistry of maitotoxin (MTX) has been established as 1B. The relative stereochemistry of the C.1−C.15 portion was elucidated via a two-phase approach: (1) the synthesis of the eight diastereomers possible for model C ...
Wanjun Zheng +6 more
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Assessment of cytotoxicity in ten strains of Gambierdiscus australes from Macaronesian Islands by neuro-2a cell-based assays [PDF]
Journal of Applied Phycology, 2018 Within the dinoflagellate genus Gambierdiscus several species are well-known producers of ciguatoxins (CTXs) and maitotoxins (MTXs). These compounds are potent marine toxins that accumulate through the food chain, leading to a foodborne disease known as ...
Anna Toldrá +2 more
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Mechanisms underlying the hemolytic and ichthyotoxic activities of maitotoxin
Natural Toxins, 1999Maitotoxin (MTX), a putative Ca(2+) channel activator produced by the dinoflagellate Gambierdiscus toxicus showed extremely potent hemolytic and ichthyotoxic activities. Hemolysis of 1% mouse blood cell suspension in saline occurred at 15 nM of MTX.
T, Igarashi, S, Aritake, T, Yasumoto
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Modulation of the maitotoxin response by intracellular and extracellular cations
Toxicon, 2002The aim of the present study was to characterize the role played by intracellular and extracellular calcium and sodium on the maitotoxin (MTX) response in Chinese hamster ovary (CHO) cells. The results presented here indicated that: (1) MTX activates calcium and sodium influx in a concentration-dependent manner; (2) extracellular calcium is required ...
V, Morales-Tlalpan, L, Vaca
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Modulation of a calcium-activated chloride current by Maitotoxin
Toxicon, 1999The effect of Maitotoxin (MTX) on the calcium-activated chloride current (ICl-Ca) from Xenopus oocytes was studied, applying the two-electrode voltage clamp technique. MTX increased the current amplitude at all the voltages explored and reduced the time to reach the maximum current level (time to peak). At low toxin concentrations (15 pM), both effects
M, Martínez +4 more
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2000
Abstract Ciguatoxin, scaritoxin, and maitotoxin (MTX) are the marine compounds held responsible for ciguatera poisoning, although the role of MTX is disputed (8). Like ciguatoxin, MTX is produced by the marine dinoflagellate Gambier discus toxicus, and accumulates in the marine food chain in fish in tropical coral reefs.
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Abstract Ciguatoxin, scaritoxin, and maitotoxin (MTX) are the marine compounds held responsible for ciguatera poisoning, although the role of MTX is disputed (8). Like ciguatoxin, MTX is produced by the marine dinoflagellate Gambier discus toxicus, and accumulates in the marine food chain in fish in tropical coral reefs.
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