Results 71 to 80 of about 641,899 (354)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Annual progress report 2013: CGIAR Research Program on Maize

, 2014
Annual progress report 2013: CGIAR Research Program on Maize ...
CGIAR Research Program on Maize
core   +1 more source

Genetic gains in early maturing maize hybrids developed by the International Maize and Wheat Improvement Center in Southern Africa during 2000–2018

Frontiers in Plant Science
Genetic gain estimation in a breeding program provides an opportunity to monitor breeding efficiency and genetic progress over a specific period. The present study was conducted to (i) assess the genetic gains in grain yield of the early maturing maize ...
Amsal Tarekegne, Dagne Wegary, Jill E. Cairns, Mainassara Zaman-Allah, Yoseph Beyene, Demewoz Negera, Adefris Teklewold, Kindie Tesfaye, MacDonald B. Jumbo, Biswanath Das, Egas J. Nhamucho, Kelvin Simpasa, Kesbell K. E. Kaonga, Kingstone Mashingaidze, Ndhlela Thokozile, Xavier Mhike, Boddupalli M. Prasanna   +16 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

CIMMYT Maize Genetic Resource Lines

, 2020
CIMMYT makes available to the public a set of maize inbred lines called CIMMYT Maize Genetic Resource Lines (CMGRL). The CMGRLs are derived from crosses between elite CIMMYT lines and landrace accessions, populations or synthetics from the CIMMYT ...
Carvalho Andrade, Marcela, Chepetla Calderon, Daniel, Crossa, Jose, Molnar, Terence, Burgueño, Juan, Chanona, Enrique Rodriguez   +5 more
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

A decade of on-farm data about improved cereal and legume cropping in Mexico

Scientific Data
This data descriptor presents a decade-long agronomic dataset collected between 2012 and 2022 by extension agents across Mexico as part of CIMMYT’s on-farm experimentation network.
Andrea Gardeazábal-Monsalve, José Alberto Cabello Cortés, Simon Fonteyne, Benancio Jiménez Gomez, Abel Jaime Leal Gonzalez, Daniel Núñez Jiménez, Sylvanus Odjo, Guadalupe Montserrat Pacheco Rodriguez, Maria de Lourdes Ramírez Ortega, Jelle Van Loon, Luis Vargas Rojas, Nele Verhulst, Bram Govaerts   +12 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Intercropping of soybean and proso millet for biomass production [PDF]

Journal on Processing and Energy in Agriculture, 2019
Sustainable agriculture considers production of high quality food and feed with minimal impact on environment. Intercropping is one of the most efficient ways to produce valuable biomass for animal feed rich in nutrients.
Milenković Milena, Simić Milena, Brankov Milan, Milojković-Opsenica Dušanka, Kresović Branka, Dragičević Vesna   +5 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source