Results 71 to 80 of about 674,405 (309)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Multi-trait association mapping for phosphorous efficiency reveals flexible root architectures in sorghum

BMC Plant Biology
Background On tropical regions, phosphorus (P) fixation onto aluminum and iron oxides in soil clays restricts P diffusion from the soil to the root surface, limiting crop yields. While increased root surface area favors P uptake under low-P availability,
Barbara Hufnagel, Karine C. Bernardino, Marcos Malosetti, Sylvia M. Sousa, Lidianne A. Silva, Claudia Teixeira Guimaraes, Antônio Marcos Coelho, Thiago Teixeira Santos, Joao H. M. Viana, Robert E. Schaffert, Leon V. Kochian, Fred A. Eeuwijk, Jurandir V. Magalhaes   +12 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Transcriptional targets of amyotrophic lateral sclerosis/frontotemporal dementia protein TDP-43 – meta-analysis and interactive graphical database

Disease Models & Mechanisms, 2022
Maize C. Cao, Emma L. Scotter
doaj   +1 more source

Response of Quality Protein Maize (QPM) hybrids for grain yield in diverse environments

The Indian Journal of Agricultural Sciences, 2020
Genotype (G) × environment (E) interaction is very important for the evaluation of cultivars in breeding programmes. Present study was conducted to assess the effect of environment and yield stability of 68 quality protein maize (QPM) hybrids at three ...
Ramesh Kumar, Jyoti Kaul, Ya shmeet Kaur, A K Das, Avinash Singode, Mukesh Choudhary, R B Dubey, D Sravani, G Mukri, S Rakshit   +9 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Identification of gray leaf spot–resistant donor lines in tropical maize germplasm and their agronomic performance under artificial inoculation

Frontiers in Plant Science
Gray leaf spot (GLS) disease is caused by two fungal pathogens, Cercospora zeae-maydis and Cercospora zeina. The current study evaluated 427 elite tropical/subtropical lines for their responses to GLS under artificial inoculation in Kakamega in western ...
L. M. Suresh, Manje Gowda, Yoseph Beyene, Dan Makumbi, Kulai Amadu Manigben, Kulai Amadu Manigben, Kulai Amadu Manigben, Juan Burgueño, Robert Okayo, Vincent W. Woyengo, Boddupalli M. Prasanna   +10 more
doaj   +1 more source

Characterization of phytohormone and transcriptome reprogramming profiles during maize early kernel development

BMC Plant Biology, 2019
Background During maize early kernel development, the dramatic transcriptional reprogramming determines the rate of developmental progression, and phytohormone plays critical role in these important processes.
Chuanyu Ma, Bo Li, Lina Wang, Ming-liang Xu, E. Lizhu, Hongyu Jin, Zhicheng Wang, Jian-rong Ye   +7 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Maize Revolutions in Sub-Saharan Africa [PDF]

There have been numerous episodes of widespread adoption of improved seed and long-term achievements in the development of the maize seed industry in Sub-Saharan Africa.
Byerlee, Derek R., Jayne, Thomas S., Smale, Melinda   +2 more
core   +4 more sources