Results 61 to 70 of about 364,533 (305)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

CIMMYT Maize Genetic Resource Lines

, 2020
CIMMYT makes available to the public a set of maize inbred lines called CIMMYT Maize Genetic Resource Lines (CMGRL). The CMGRLs are derived from crosses between elite CIMMYT lines and landrace accessions, populations or synthetics from the CIMMYT ...
Carvalho Andrade, Marcela, Chepetla Calderon, Daniel, Crossa, Jose, Molnar, Terence, Burgueño, Juan, Chanona, Enrique Rodriguez   +5 more
core   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

CGIAR Research Program on Maize - Plan of Work and Budget 2020

, 2020
No new adjustments planned, however adjustments initiated in 2019 will continue in 2020: • FP3: Continue to update Theory of Change and Impact Pathway (ToC & IP) by adding a consumer/demand-foresight component to MAIZE breeding product profiles. By 2021,
CGIAR Research Program on Maize
core  

Comparative genomics of Arabidopsis and maize: prospects and limitations [PDF]

, 2002
Brendel V, Kurtz S, Walbot V. Comparative genomics of Arabidopsis and maize: prospects and limitations. Genome Biology. 2002;3(3): reviews1005.1.The completed Arabidopsis genome seems to be of limited value as a model for maize genomics.
Walbot, Virginia, Brendel, Volker, Kurtz, Stefan   +2 more
core   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Change in seed viability of commercial maize hybrids during storage [PDF]

Selekcija i Semenarstvo
The production and processing of commercial seeds place significant emphasis on seed quality, with germination rates being a critical determinant of market performance.
Perić Sanja, Stevanović Milan, Mladenović Marko, Popović Aleksandar, Kovačević Aleksandar, Grčić Nikola   +5 more
doaj   +1 more source