Results 131 to 140 of about 7,978,447 (307)

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Meta Analysis of DHA and EPA Supplementation on Cardiovascular Outcomes and Atrial Fibrillation Risk

Pharmacology Research & Perspectives
Cardiovascular diseases (CVD) remain to impose a main global burden of morbidity and mortality despite advances in anticipation and treatment. Omega‐3 fatty acids, mainly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been extensively ...
Sepideh Karkon Shayan, Rosull Saadoon Abbood, Sarah F. Al‐Taie, Paria Ganji Nataj, Maksudova Malika Khamdamjonovna, Siamak Aminnezhad, Yasaman Ghodsi Boushehri, Jabbarov Jamoliddin Sindorovich, Ali Sinehsepehr, Farshad Zare, Seyed Abbas Pakmehr, Elham Abdollahi, Milad Vahedinezhad   +12 more
doaj   +1 more source

Time to benefit of colchicine in patients with cardiovascular disease: A pooled analysis of randomized controlled trials

Heliyon
Background: Low-dose colchicine has been shown to lower major adverse cardiovascular events (MACE) among those with cardiovascular disease (CVD). It remains unclear how long a CVD patient needs to live to potentially benefit from colchicine.
Haonan Sun, Chuanyi Huang, Linjie Li, Wenjun Zhu, Jingge Li, Pengfei Sun, Geru A, Gregg C. Fonarow, Qing Yang, Xin Zhou   +9 more
doaj   +1 more source

MXene‐Based Room‐Temperature NO2 Gas Sensors: A Meta‐Analysis

Advanced Science, EarlyView.
This study presents the first comprehensive meta‐analysis of MXene‐based NO2 sensors, decoding 32 study characteristics across 61 peer‐reviewed studies. By isolating materials chemistry as the primary performance driver over device‐level parameters, the authors establish a methodological blueprint and a predictive structure–function map to accelerate ...
Alexander Khort, Jerome Geyer‐Klingeberg, Andreas Rathgeber, Suelen Barg   +3 more
wiley   +1 more source

Increased Disarray of Extracellular Matrix Collagen‐I Fiber Network and Compromised Biomechanics in Aortae From Marfan‐Syndrome Mice Assessed Through Combined Opto‐Biomechatronics

Advanced Science, EarlyView.
Combined structure‐function assessment in aortic rings from Marfan mice using MechaMorph Opto‐Biomechatronics technology relates increased elasticity (stiffness) and dynamic viscosity and less ordered extracellular matrix 3D‐structure (collagen) as potential causes for impaired Windkessel function and compromised haemodynamics in Marfan's syndrome ...
Dominik Schneidereit, Anika Nagel, Vanessa I. T. Zwaans, Laureen Schurr, Jonas Ahr, Michael Haug, Anna Piluso, Alexandra Sporkova, Matthias Karck, Andreas H. Wagner, Oliver Friedrich   +10 more
wiley   +1 more source

Safety outcomes of immunotherapy continuation versus permanent discontinuation after immune checkpoint inhibitor-associated myocarditis in patients with lung cancer

Shanghai Jiaotong Daxue xuebao. Yixue ban
Objective·To compare the safety outcomes between immunotherapy continuation and permanent immunotherapy discontinuation in patients with lung cancer who developed immune checkpoint inhibitor-associated myocarditis (ICI-M).Methods·This single-center ...
Liu Zhitong, Fan Zixu, Li Xiang, Zhang Min   +3 more
doaj   +1 more source

Restoring Endothelial Mitochondrial Homeostasis With a Bioactive Nanoshield Promotes Vascular Regeneration on Cardiovascular Implants

Advanced Science, EarlyView.
A bioactive poly(citrate‐polyglycol‐procyanidin) (PCGP) nanoshield is developed for cardiovascular implants to restore endothelial mitochondrial homeostasis following vascular injury. By preserving mitochondrial integrity, re‐establishing metabolic balance, and activating PI3K/Akt/eNOS‐NO signaling, the PCGP interface promotes functional endothelial ...
Xiyu Liu, Wen Zhang, Lunxin Liu, Lan Gui, Yumei Qin, Xiaohui Yang, Longjian Zhang, Chaohua Wang, Jinpeng Hu, Gaoyang Guo, Qing Jiang, Jin Wang, Li Yang, Bo Zhang, Yunbing Wang   +14 more
wiley   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Early Major Adverse Cardiovascular Event in a Patient With Chronic Kidney Disease: A Case Report. [PDF]

Cureus, 2023
Saleh Juman Alseiari S, Fadil Ali Al Thehli R, Farooq M.   +2 more
europepmc   +1 more source

Cox regression analysis for major adverse cardiovascular events, all cause mortality and cardiovascular mortality.

, 2014
Abbreviation as table 1; CI: confidence interval.Cox regression analysis for major adverse cardiovascular events, all cause mortality and cardiovascular mortality.
Hung-I Yeh (378406), Min-I Su (642751), Cheng-Ting Tsai (642752), Chun-Yen Chen (642753)   +3 more
core   +1 more source