Results 141 to 150 of about 7,978,447 (307)

STING/Type I Interferon Pathway Activation Confers Multimodal Therapeutic Benefits in Osteomyelitis

Advanced Science, EarlyView.
STING/type I interferon signaling counteracts osteomyelitis through coordinated control of pain, bone destruction, and abscess formation. It inhibits pathogen‐induced nociceptor activation, restrains osteoclast‐mediated bone resorption, and suppresses IL‐1β‐driven neutrophil recruitment.
Yang Chen, Jianhua Lv, Yuanqing Cai, Xuhui Yuan, Hongxin Hu, Jiayu Li, Yiming Lin, Hongyan Li, Lan Lin, Huangfeng Lin, Chaofan Zhang, Qijin Wang, Ying Huang, Zida Huang, Wenbo Li, Susheng Niu, Jianhua Lin, Bin Yang, Xinyu Fang, Wenming Zhang   +19 more
wiley   +1 more source

Risk of Major Adverse Cardiovascular Event Following Incident Hospitalization for Acute Gout: A Western Australian Population-Level Linked Data Study. [PDF]

ACR Open Rheumatol, 2023
Lopez D, Dwivedi G, Nossent J, Preen DB, Murray K, Raymond W, Inderjeeth C, Keen HI.   +7 more
europepmc   +1 more source

Major adverse cardiovascular event

, 2020
Joachim Feger, Rohit Sharma, Francesco Sciacca   +2 more
openaire   +1 more source

Major adverse cardiovascular events of the patients with CAD followed-up.

, 2013
Major adverse cardiovascular events of the patients with CAD followed-up.
Naifeng Liu (311606), Yi Feng (29944), Yang Li (7082), Yanan Ji (345237), Chengxing Shen (311601), Genshan Ma (150359)   +5 more
core   +1 more source

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

Perioperative Risk of Noncardiac Surgery in Patients With Asymptomatic Significant Aortic Stenosis: A 10‐Year Retrospective Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Aortic stenosis (AS) is a representative geriatric disease, and there is an anticipated rise in the number of patients requiring noncardiac surgeries in patients with AS.
Minjung Bak, Seung‐Hwa Lee, Sung‐Ji Park, Jungchan Park, Jihoon Kim, Darae Kim, Eun Kyoung Kim, Sung‐A Chang, Sang‐Chol Lee, Seung Woo Park   +9 more
doaj   +1 more source

Oral Recombinant Human Collagen III Protects Gastric Mucosa via G‐Quadruplex‐Mediated Activation of the Pla2g4a‐Prostaglandin Axis

Advanced Science, EarlyView.
Orally administered recombinant human type III collagen protects the gastric mucosa from ethanol‐induced injury by coordinating redox homeostasis, epithelial barrier repair, and arachidonic acid–prostaglandin metabolism. Gastric digestion releases the pentapeptide GPAEF, which interacts with the Pla2g4a promoter G‐quadruplex in a structure‐dependent ...
Xinyue Lan, Qiu Dai, Yanhui Wang, Jiaxuan Gu, Chengyun Wang, Weicheng Xu, Xinru Gao, Jiageng Cheng, Wentao Geng, Xiaowen Wu, Haihang Li, Xiaoyun He, Shengwei Fu, Longjiao Zhu, Wentao Xu   +14 more
wiley   +1 more source

Amyloidosis in Carpal Tunnel Syndrome and 1‐Year Cardiovascular and Renal Outcomes: A Propensity Score–Matched Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Carpal tunnel syndrome (CTS) has been recognized as a potential early manifestation of systemic amyloidosis; however, its prognostic implications for cardiovascular and renal outcomes remain unclear.
Wei‐Ting Wang, Jung‐Pan Wang, Jui‐Yi Chen   +2 more
doaj   +1 more source

Effectiveness of lipid-lowering therapy on mortality and major adverse cardiovascular event outcomes in patients undergoing percutaneous coronary intervention: a network meta-analysis of randomised controlled trials. [PDF]

BMJ Open, 2023
Deng CJ, Yan J, Zheng YY, Wu TT, Pan Y, Hou XG, Wang SF, Sirajidin S, Aimaitijiang M, Xie X.   +9 more
europepmc   +1 more source

Metabolic syndrome with mortality and major adverse cardiovascular events in an elderly population

Frontiers in Endocrinology
BackgroundCardiovascular disease (CVD) remains a leading cause of morbidity and mortality globally, with metabolic syndrome (MS) being a significant contributor to major adverse cardiovascular events (MACE). While the relationship between MS and CVD is well established, limited studies have focused on elderly populations, particularly in the context of
Shailendra Kumar Karn, Fang Zhao, Yawei Xu, Yi Zhang, Chunlai Zeng, Imran Ibrahim Shaikh, Shekhar Singh, Yuling Feng, Yuling Feng   +8 more
openaire   +3 more sources