Results 151 to 160 of about 7,978,447 (307)

Versatile Microgel Platform for Intervertebral Disc Degeneration Therapy: Targeting Pericyte‐Mediated Fibrosis and Protecting Nucleus Pulposus Cells

Advanced Science, EarlyView.
The engineered MMS@TRP microgel enables targeted, acid‐responsive delivery of a miR‐21 inhibitor to pericytes. It effectively suppresses disc fibrosis by inhibiting TGF‐β signaling while protecting nucleus pulposus cells via sustained, antioxidant tannic acid release.
Fei Ma, Zhen Zhao, Chuan Guo, Yuheng Liu, Yu Wang, Dengbo Yao, Weiqiang Lan, Dejun Zhong, Chen Fan, Yao He, Mei Zhang, Qingquan Kong, Yunfeng Lin   +12 more
wiley   +1 more source

Univariate analysis for predictors of major adverse cardiovascular events.

, 2015
ACS: acute coronary syndrome;hsCRP: high sensitivity C-reactive protein;LVEF: left ventricular ejection fraction.Univariate analysis for predictors of major adverse cardiovascular events.
Chun-Chi Chen (103097), Chia-Hung Yang (800326), Ming-Lung Tsai (651350), Ming-Jer Hsieh (103100), Shang-Hung Chang (103093), I-Chang Hsieh (103109), Dong-Yi Chen (319219), Chao-Yung Wang (103103), Cheng-Hung Lee (103106)   +8 more
core   +1 more source

Low‐Intensity Ultrasound‐Triggered Microbubble Cavitation Attenuates Diabetic Kidney Injury Partially by Reversing Endothelial Dysfunction

Advanced Science, EarlyView.
Non‐invasive low‐intensity pulsed ultrasound ‐triggered cavitation of clinically approved diagnostic‐grade microbubbles delivers favorable mechanical stimuli to renal microvasculature. This intervention restores renal microvascular homeostasis, alleviates DKD‐associated histological and functional damage, and suppresses inflammatory and fibrotic ...
Yubo Lai, Liang Zhang, Wenxin Tao, Jieyuan An, Lantian Wang, Zhaoyou Liu, Guodong Yang, Pengying Wu, Lijun Yuan   +8 more
wiley   +1 more source

Subgroup analysis for (A) major adverse cardiovascular events (MACE), and (B) stroke.

, 2014
Subgroup analysis for (A) major adverse cardiovascular events (MACE), and (B) stroke.
El-Wui Loh (608396), Jin-Long Huang (599641), Tsu-Juey Wu (459389), Yu-Cheng Hsieh (599643), Chen-Ying Hung (608395), Ching-Heng Lin (512565), Kuo-Yang Wang (599645)   +6 more
core   +1 more source

Extracellular Vesicle Packaged TDP43 Derived From ECs Exacerbates Cigarette Tar‐Related Atherosclerosis Progression via Enhancing Macrophage Extracellular Traps

Advanced Science, EarlyView.
Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.
Xinxin Zhu, Yuwu Chen, Wei Meng, Biyi Xu, Junke Mou, Xiaolin Liu, Mengyang Wang, Qishuo Gu, Qianhui Sun, Man Li, Chen Zhao, Ming Zeng, Ying Lv, Boling Yi, Sheng Qu, Xiaoxuan Bai, Ji Li, Xing Luo, Sining Hu, Bo Yu, Haibo Jia   +20 more
wiley   +1 more source

Endocan and Major Adverse Cardiovascular Events: Understanding Regression Methods [PDF]

Angiology, 2019
Uğur Aksu, Oktay Gulcu, Emrah Aksakal, Kamuran Kalkan   +3 more
openaire   +3 more sources

Kaplan Meier survival curves for major adverse cardiovascular outcomes by QTcB interval.

, 2016
Kaplan Meier survival curves for major adverse cardiovascular outcomes by QTcB interval.
A. Mark Richards (154622), Jonathan Yap (340751), Carolyn S. P. Lam (613688), Ai Zhen Jin (509598), Shwe Zin Nyunt (2697721), Tze Pin Ng (292182)   +5 more
core   +1 more source

Context‐Dependent Inverse Association of Glucose–Lipid Metabolic Status With Anemia: Evidence From Multinational Multicohort Analyses

Advanced Science, EarlyView.
Across six multinational cohorts, higher triglyceride–glucose index values are consistently associated with lower prevalent and incident anemia, despite their established adverse cardiometabolic significance. This inverse relationship varies across inflammatory, cardiovascular, and renal contexts, suggesting that glucose–lipid metabolic status carries ...
Guosong Jiang, Xinxing Wang, Lianfeng Xie, Wenna Ding, Yingyong Yin, Mei Yao, Zhibo Cui, Kaiqiang Tang, Lijie Zhong, Zhi Wang, Jia Wang, Lei Lei, Xiaoxiao Qu, Chi‐E. Qiu   +13 more
wiley   +1 more source

PREDIABETES ASSOCIATED WITH AN INCREASE IN MAJOR ADVERSE CARDIOVASCULAR EVENTS

Journal of the American College of Cardiology, 2021
Adrian Michel, Ramy Mando, Muhammad Abdul-Aziz Waheed, Alexandra Halalau, Patrick Karabon   +4 more
openaire   +1 more source

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source