Results 51 to 60 of about 207,642 (302)

Executive functions in major depressive disorder

Sri Lanka Journal of Psychiatry, 2018
BackgroundIt is reported that executive functions are impaired in a variety of neuropsychiatric syndromes, including depressive disorders. Studies on executive functions in depressive disorders are inconclusive.
K. Dhawan, C.Y. Sudarshan, S. Begum
doaj   +1 more source

Anxiety disorders in major depression

Comprehensive Psychiatry, 2000
The prevalence and clinical impact of anxiety disorder comorbidity in major depression were studied in 255 depressed adult outpatients consecutively enrolled in our Depression Research Program. Comorbid anxiety disorder diagnoses were present in 50.6% of these patients and included social phobia (27.0%), simple phobia (16.9%), panic disorder (14.5 ...
Joel A. Pava, Meridith A. Rankin, Andrew A. Nierenberg, Maurizio Fava, Jerrold F. Rosenbaum, Emma C. Wright, Jonathan E. Alpert   +6 more
openaire   +3 more sources

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

Advanced Healthcare Materials, EarlyView.
This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla, Vincenzo Verdi, Willemijn de Voogt, Mariona Estapé Sentí, Arnold C. Koekman, Julian Rietveld, Sven van Kempen, Qiangbing Yang, Juliette van Merris, Guido Jenster, Martin E. van Royen, Marcel H. Fens, Sander A. A. Kooijmans, Wytske M. van Weerden, Guillaume van Niel, Pieter Vader, Raymond M. Schiffelers   +16 more
wiley   +1 more source

The association between aids related stigma and major depressive disorder among HIV-positive individuals in Uganda. [PDF]

PLoS ONE, 2012
BackgroundMajor depressive disorder in people living with HIV/AIDS (PLWHA) is common and may be associated with a number of factors, including AIDS-related stigma, decreased CD4 levels, increased opportunistic infections and sociodemographic variables ...
Dickens Akena, Seggane Musisi, John Joska, Dan J Stein   +3 more
doaj   +1 more source

Miniaturized Wireless tDCS With Concentric Electrodes for Targeted Cortical Stimulation in Freely Moving Mice

Advanced Healthcare Materials, EarlyView.
This study introduces a wireless and miniaturized concentric‐electrode tDCS (CE‐tDCS) system tailored for freely moving mice. The device enables focal and multi‐site cortical stimulation via a lightweight, Bluetooth‐controlled platform. By integrating local neuromodulation with real‐time behavioral analysis, the system provides a robust tool for ...
Minseok Kim, Sehwan Park, Haeyun Lee, Giheon Kim, Namsun Chou, Hyogeun Shin   +5 more
wiley   +1 more source

Advances in Photonic Materials and Integrated Devices for Smart and Digital Healthcare: Bridging the Gap Between Materials and Systems

Advanced Materials, EarlyView.
This article summarizes significant technological advancements in materials, photonic devices, and bio‐interfaced systems, which demonstrate successful applications for impacting human healthcare via improved therapies, advanced diagnostics, and on‐skin health monitoring.
Seunghyeb Ban, Hoon Yi, Jaejin Park, Yunuo Huang, Ki Jun Yu, Woon‐Hong Yeo   +5 more
wiley   +1 more source

An Ultrapotent, Ultraeconomical, Antifreeze Polypeptide

Advanced Materials, EarlyView.
Simple and inexpensive polypeptides composed of random copolymers of alanine and glutamic acid are effective antifreezes for applications in foods and biomedicine. The polypeptides, inspired by natural extremophile proteins, inhibit the growth of large ice crystals and prevent damage to sensitive biologics.
Thomas J. McPartlon, Charles T. Osborne, Ke Wang, Rachel E. Detwiler, Konrad Meister, Jessica R. Kramer   +5 more
wiley   +1 more source

Designing the Next Generation of Biomaterials through Nanoengineering

Advanced Materials, EarlyView.
Nanoengineering enables precise control over biomaterial interactions with living systems by tuning surface energy, defects, porosity, and crystallinity. This review highlights how these nanoscale design parameters drive advances in regenerative medicine, drug delivery, bioprinting, biosensing, and bioimaging, while outlining key translational ...
Ryan Davis Jr., Ishaan Duggal, Nicholas A. Peppas, Akhilesh K. Gaharwar   +3 more
wiley   +1 more source

Spin Engineering of Dual‐Atom Site Catalysts for Efficient Electrochemical Energy Conversion

Advanced Materials, EarlyView.
This review highlights recent progress in spin engineering of dual‐atom site catalysts (DASCs), emphasizing how spin‐related properties enhance electrocatalytic activity, selectivity, and stability. It summarizes cutting‐edge developments in dual‐atom catalysis, discusses the underlying spin‐catalysis mechanisms and structure–performance relationships,
Dongping Xue, Yu Zhao, Jianliang Cao, Yan Wang, Xiaoning Li, Tianyi Ma   +5 more
wiley   +1 more source

Desvenlafaxine in the treatment of major depressive disorder

Neuropsychiatric Disease and Treatment, 2009
Maria Teresa C Lourenco1, Sidney H Kennedy1,21Department of Psychiatry, University Health Network, Toronto; 2Department of Psychiatry, University of Toronto, Toronto, CanadaAbstract: Major depressive disorder (MDD) is among the most incapacitating ...
Maria Teresa C Lourenco1, Sidney H Kennedy1,2   +1 more
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