Results 51 to 60 of about 167 (159)

The effects of coloring therapy on patients with generalized anxiety disorder

Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 502-512, December 2022., 2022
After the intervention, there were statistical differences intra‐and‐inter group comparisons of anxiety, depression, and positive and negative mood scales in the experimental and control groups (p < .05). The minus in anxiety/positive emotions pre‐and‐post intervention in the experimental group was statistically significant compared to the minus in ...
Bosomtwe Samuel, Hongmei Wang, Chengdong Shi, Yongliang Pan, Yuzi Yu, Weiyu Zhu, Zhou Jing   +6 more
wiley   +1 more source

Perillaldehyde Improves Parkinson‐Like Deficits by Targeting G3BP Mediated Stress Granule Assembly in Preclinical Models

Advanced Science, EarlyView.
This study uncovers that stress granules (SGs) are involved in the pathogenesis of Parkinson's disease (PD). Perillaldehyde (PAE) can improve Parkinson‐like deficits in preclinical models by directly binding to G3BP and instigating liquid–liquid phase separation (LLPS) of G3BP.
Minglv Fang, Lingling Luo, Youjia Chen, Ying Liu, Yingxuan Yan, Fei Wang, Yan Zou, Huanhu Zhu, Xiaojun Wu, Zhigang Jin, Cheng Huang, Yu Zhang, Shengjie Fan   +12 more
wiley   +1 more source

Multifunctional Boron‐based 2D Nanoplatforms Ameliorate Severe Respiratory Inflammation by Targeting Multiple Inflammatory Mediators

Advanced Science, EarlyView.
There are many limitations of conventional corticosteroids in the treatment of respiratory inflammation. Here, a multifunctional 2D nanoplatform is designed that simultaneously targets cfDNA, NETs, RONS, and bacterial infection. The nanoplatforms exhibited excellent therapeutic efficacy in vivo and could serve as a new therapeutic approach for severe ...
Changyi Xu, Ming Liu, Xinran Xie, Zhixin Li, Yuefei Zhu, Yang Ye, Mengya Du, Suhua Hu, Tianrun Liu, Yubiao Guo, Weiping Wen, Huanliang Liu, Zhaoxu Tu   +12 more
wiley   +1 more source

A Molecularly Defined Medullary Network for Control of Respiratory Homeostasis

Advanced Science, EarlyView.
The dynamic interplay between central respiratory chemoreceptors and the respiratory central pattern generator is essential for maintaining stable respiratory rhythm and patterns, particularly during sleep. This study offers novel insights into the anatomical, molecular, and functional characteristics of a medullary network involving the nucleus ...
Tianjiao Deng, Xinyi Jing, Liuqi Shao, Yakun Wang, Congrui Fu, Hongxiao Yu, Xiaoyi Wang, Xue Zhao, Fanrao Kong, Yake Ji, Xiaochen Tian, Wei He, Shangyu Bi, Luo Shi, Hanqiao Wang, Fang Yuan, Sheng Wang   +16 more
wiley   +1 more source

Advances in Fecal Microbiota Transplantation for Gut Dysbiosis‐Related Diseases

Advanced Science, EarlyView.
This article reviews the use of fecal microbiota transplantation (FMT) to treat intestinal diseases like recurrent Clostridioides difficile infection (rCDI), inflammatory bowel disease (IBD), and irritable bowel syndrome (IBS). It discusses FMT's efficacy, influencing factors such as donor selection, recipient characteristics, and treatment protocols ...
Shuna Hou, Jiachen Yu, Yongshuang Li, Duoyi Zhao, Zhiyu Zhang   +4 more
wiley   +1 more source

Prefrontal FGF1 Signaling is Required for Accumbal Deep Brain Stimulation Treatment of Addiction

Advanced Science, EarlyView.
This research delineates that a cortical‐accumbal pathway and local FGF1 signaling in the medial prefrontal cortex are critical for NAc‐DBS to be effective in altering morphine CPP. These findings demonstrate a top‐down motif to regulate the therapeutic effects of subcortical DBS on addiction and support the potential for addiction treatments involving
Wan‐Kun Gong, Xue Li, Le Wang, Qian Yang, Alix Tiran‐Cappello, Zhichao Liang, James Samsom, Quanying Liu, He Lin, Christelle Baunez, Fang Liu, Ti‐Fei Yuan   +11 more
wiley   +1 more source

Psychedelic Drugs in Mental Disorders: Current Clinical Scope and Deep Learning‐Based Advanced Perspectives

Advanced Science, EarlyView.
Graphic illustration showing the strategic approaches based on the currently investigated evidence of psychedelics that suggests the challenges and how to address the prescription of mental disorders. These applicable avenues may provide substantial insight into distinguishing between brain networks and psychedelics.
Sung‐Hyun Kim, Sumin Yang, Jeehye Jung, Jeonghyeon Choi, Mingon Kang, Jae‐Yeol Joo   +5 more
wiley   +1 more source

Cortical Morphometric Similarity Remodeling in Traumatic Brain Injury Links Cognitive Impairments with Transcriptional Changes and Type‐Specific Cells

Advanced Science, EarlyView.
A cross‐scale framework utilizing morphological similarity (MS) to connect macroscopic dysfunctions and microscopic changes after traumatic brain injury (TBI). The MS remodeling focused on frontal and occipital cortices is associated with heterogeneous cognitive outcomes after TBI and is spatially correlated with gene overexpression on CA1 pyramidal ...
Yizhen Pan, Zhuonan Wang, Xiang Zhang, Wenpu Zhao, Haonan Zhang, Xuan Li, Xiaoyan Jia, Qiuyu Ji, Bo Yin, Guanghui Bai, Tingting Wu, Zhiqi Lee, Jierui Ding, Lei Shi, Jie Zhang, David H. Salat, Lijun Bai   +16 more
wiley   +1 more source

Identification of Three Distinct Subgroups in Antiphospholipid Syndrome: Implication for Sex Differences and Prognostic Outcomes from a Multicenter Study

Advanced Science, EarlyView.
A large‐scale, multicenter, and two‐stage study is conducted to define antiphospholipid syndrome (APS) subgroups. By applying unsupervised K‐means clustering algorithm, the authors identified three distinct APS subgroups: obstetric APS, female thrombotic APS (tAPS), and male tAPS, which display marked differences in clinical manifestations and ...
Chen Chen, Ao Zhang, Jianhui Cheng, Zhongqiang Yao, Juan Meng, Yilu Qin, Qingyi Lu, Yufei Li, Xiangjun Liu, Tianhao Li, Chao Hou, Yundi Tang, Hongjiang Liu, Ning Xu, Sai Dong, Xinxin Li, Fangmin Xu, Jianping Guo, Chun Li   +18 more
wiley   +1 more source

Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding

Advanced Science, EarlyView.
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen, Yuwei Zhou, Wenxiu Yuan, Yanjing Ou, Hanyu Lin, Kaixun He, Xueshen Qian, Huachen Chen, Chengchaozi Wang, Jie Lu, Weiping Chen, Dexiong Li, Jiang Chen   +12 more
wiley   +1 more source