Results 41 to 50 of about 322,474 (305)

Development of predictive algorithms for electrical stimulation based major depressive disorder therapy [PDF]

, 2018
University of Technology Sydney. Faculty of Engineering and Information Technology.Major depressive disorder (MDD) is a brain disorder that is characterised by negative thoughts, mood and behaviour.
Al-Kaysi, Alaa Mohammed Dawood
core  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Pharmacological management of major depressive disorder

, 2022
Major depressive disorder [MDD] is a highly prevalent psychiatric disorder that causes significant impairment in different areas of one's life. There are multiple factors contributing to the development of MDD including genetic, environmental, and ...
Ojiako, Chiamaka Priscilla
core  

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Anxiety disorders in major depression

Comprehensive Psychiatry, 2000
The prevalence and clinical impact of anxiety disorder comorbidity in major depression were studied in 255 depressed adult outpatients consecutively enrolled in our Depression Research Program. Comorbid anxiety disorder diagnoses were present in 50.6% of these patients and included social phobia (27.0%), simple phobia (16.9%), panic disorder (14.5 ...
M, Fava, M A, Rankin, E C, Wright, J E, Alpert, A A, Nierenberg, J, Pava, J F, Rosenbaum   +6 more
openaire   +2 more sources

Epigenetic Aging in Major Depressive Disorder [PDF]

American Journal of Psychiatry, 2018
Major depressive disorder is associated with an increased risk of mortality and aging-related diseases. The authors examined whether major depression is associated with higher epigenetic aging in blood as measured by DNA methylation (DNAm) patterns, whether clinical characteristics of major depression have a further impact on these patterns, and ...
Han, LKM, Aghajani, M, Clark, SL, Chan, RF, Hattab, MW, Shabalin, AA, Zhao, M, Kumar, G, Xie, LY, Jansen, R, Milaneschi, Y, Dean, B, Aberg, KA, van den Oord, EJCG, Penninx, BWJH   +14 more
openaire   +6 more sources

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

Multi-site benchmark classification of major depressive disorder using machine learning on cortical and subcortical measures [PDF]

Machine learning (ML) techniques have gained popularity in the neuroimaging field due to their potential for classifying neuropsychiatric disorders. However, the diagnostic predictive power of the existing algorithms has been limited by small sample ...
ENIGMA Major Depressive Disorder working group
core   +2 more sources

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

A Comparison of Sexual Dysfunctions in Female Patients with Major Depressive Disorder and Panic Disorder

Bilişsel Davranışçı Psikoterapi ve Araştırmalar Dergisi, 2014
Objective: The aim of this study is assessment of sexual dysfunction in female patients with major depressive disorder and panic disorder and compare the two groups. Methods: Total 76 female patients with primary diagnosis of major depressive disorder (
Tonguç Demir Berkol, Süheyla Doðan Bulut, Esra Alataþ, Dicle Görkem, Esra Çavdar, Ýlker Özyýldýrým   +5 more
doaj   +1 more source