Results 21 to 30 of about 322,474 (305)

Sleep deprivation in bright and dim light: antidepressant effects on major depressive disorder [PDF]

open access: yes, 1990
Twenty-three patients with a major depressive disorder were deprived of a night’s sleep twice weekly, one week staying up in the dimly lit living room of the ward (< 60 lux), and one week in a brightly lit room (> 2000 lux).
Bouhuys, A.L.   +7 more
core   +1 more source

Major depressive disorder in detention officers

open access: yesRevista de Saúde Pública, 2021
OBJECTIVE To identify factors associated with major depressive disorder (MDD) in detention officers. METHODS This cross-sectional study included all detention officers from the largest prison complex in the state of Bahia, Brazil.
Sheila Nascimento Santos   +3 more
doaj   +2 more sources

SUMOylation and Major Depressive Disorder

open access: yesInternational Journal of Molecular Sciences, 2022
Since the discovery of the small ubiquitin-like modifier (SUMO) protein in 1995, SUMOylation has been considered a crucial post-translational modification in diverse cellular functions. In neurons, SUMOylation has various roles ranging from managing synaptic transmitter release to maintaining mitochondrial integrity and determining neuronal health.
Seok-Won Jeoung   +5 more
openaire   +2 more sources

Epidemiology and heritability of Major Depressive Disorder, stratified by age of onset, sex, and illness course in Generation Scotland:Scottish Family Health Study (GS:SFHS) [PDF]

open access: yes, 2015
The heritability of Major Depressive Disorder (MDD) has been estimated at 37% based largely on twin studies that rely on contested assumptions. More recently, the heritability of MDD has been estimated on large populations from registries such as the ...
Andrew G. McKechanie (827281)   +78 more
core   +1 more source

A gene co-expression network-based analysis of multiple brain tissues reveals novel genes and molecular pathways underlying major depression.

open access: yesPLoS Genetics, 2019
Major depression is a common and severe psychiatric disorder with a highly polygenic genetic architecture. Genome-wide association studies have successfully identified multiple independent genetic loci that harbour variants associated with major ...
Zachary F Gerring   +3 more
doaj   +1 more source

Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder [PDF]

open access: yes, 2015
Genetic risk prediction has several potential applications in medical research and clinical practice and could be used, for example, to stratify a heterogeneous population of patients by their predicted genetic risk.
Caesar, Sian   +846 more
core   +1 more source

Serum level of soluble interleukin 6 receptor is a useful biomarker for identification of treatment‐resistant major depressive disorder

open access: yesNeuropsychopharmacology Reports, 2020
Aim A substantial proportion of major depressive disorder patients are treatment‐resistant to antidepressant therapy, who require augmentation drugs, or other treatments including electroconvulsive therapy or transcranial magnetic stimulation ...
Katsuhiko Yamasaki   +2 more
doaj   +1 more source

Do Suicide Attempts of Mood Disorder Patients Directly Increase the Risk for a Reattempt?

open access: yesFrontiers in Psychiatry, 2020
Background: Preceding suicide attempts strongly predict future suicidal acts. However, whether attempting suicide per se increases the risk remains undetermined.
Kari I. Aaltonen   +17 more
doaj   +1 more source

Depression: Special Considerations for the Dental Setting

open access: yesMedEdPORTAL, 2011
The 1-year prevalence rate for depression is 9.5%, or approximately 20.9 million adults in America. The lifetime prevalence of major depressive disorder is approximately 10%-25%.
Jessica G. Hinz
doaj   +1 more source

Patient-reported outcomes in major depressive disorder with suicidal ideation: a real-world data analysis using PatientsLikeMe platform

open access: yesBMC Psychiatry, 2020
Background The current analysis utilized data collected via an online patient community platform, PatientsLikeMe (PLM) to compare patient-reported experiences in patients with major depressive disorder (MDD) with suicidal ideation (MDSI) to those with ...
Stephane Borentain   +3 more
doaj   +1 more source

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