Results 21 to 30 of about 290,882 (260)

Adult Separation Anxiety Disorder in the Geriatric Population with Major Depressive Disorder

Neuropsychiatric Investigation, 2022
Objective: Separation anxiety disorder is a disorder with childhood-onset, which manifests itself also in adulthood and is often comorbid with other psychiatric disorders.
Feride Yıldırım, Aslı Beşirli
doaj   +1 more source

Real-world assessment of treatment inertia in the management of patients treated for major depressive disorder in the USA

Journal of Comparative Effectiveness Research, 2023
Aim: Major depressive disorder (MDD) is a debilitating illness in which depressive symptoms may persist after treatment. Treatment inertia is the continued use of the same pharmacotherapy regimen when treatment goals are not met.
John J Sheehan, Chris LaVallee, Keshia Maughn, Santosh Balakrishnan, Jacqueline A Pesa, Kruti Joshi, Craig Nelson   +6 more
doaj   +1 more source

Suicide‐specific mortality among patients with treatment‐resistant major depressive disorder, major depressive disorder with prior suicidal ideation or suicide attempts, or major depressive disorder alone

Brain and Behavior, 2023
Background The impact of treatment‐resistant depression (TRD) or prior suicidal ideation/suicide attempt (SI/SA) on mortality by suicide among patients with major depressive disorder (MDD) is not well known. This retrospective, observational, descriptive
David M. Kern, Carla M. Canuso, Ella Daly, Jonathan C. Johnson, Dong Jing Fu, Teodora Doherty, Cori Blauer‐Peterson, M. Soledad Cepeda   +7 more
doaj   +1 more source

Brain aging in major depressive disorder

European Psychiatry, 2021
Depression and anxiety are common and often comorbid mental health disorders that represent risk factors for aging-related conditions. Brain aging has shown to be more advanced in patients with Major Depressive Disorder (MDD).
L. Han, H. Schnack, R. Brouwer, D. Veltman, N. Van Der Wee, M.-J. Van Tol, M. Aghajani, B. Penninx   +7 more
doaj   +1 more source

Major depressive disorder in detention officers

Revista de Saúde Pública, 2021
OBJECTIVE To identify factors associated with major depressive disorder (MDD) in detention officers. METHODS This cross-sectional study included all detention officers from the largest prison complex in the state of Bahia, Brazil.
Sheila Nascimento Santos, Kionna Oliveira Bernardes Santos, Fernando Martins Carvalho, Rita de Cássia Pereira Fernandes   +3 more
doaj   +2 more sources

What patients with bipolar disorder and major depressive disorder perceive as adverse life events precipitating a current major depressive episode

South African Journal of Psychiatry, 2015
Background. Adverse life events (ALEs) as precipitants of a major depressive episode (MDE) have been the subject of many studies. These studies indicate an increase in ALEs in the 6 months preceding an MDE. Objectives.
Robyn Anne van Schoor, Pierre M Joubert
doaj   +1 more source

SUMOylation and Major Depressive Disorder

International Journal of Molecular Sciences, 2022
Since the discovery of the small ubiquitin-like modifier (SUMO) protein in 1995, SUMOylation has been considered a crucial post-translational modification in diverse cellular functions. In neurons, SUMOylation has various roles ranging from managing synaptic transmitter release to maintaining mitochondrial integrity and determining neuronal health.
Seok-Won Jeoung, Hyun-Sun Park, Zae Young Ryoo, Dong-Hyung Cho, Hyun-Shik Lee, Hong-Yeoul Ryu   +5 more
openaire   +2 more sources

A gene co-expression network-based analysis of multiple brain tissues reveals novel genes and molecular pathways underlying major depression.

PLoS Genetics, 2019
Major depression is a common and severe psychiatric disorder with a highly polygenic genetic architecture. Genome-wide association studies have successfully identified multiple independent genetic loci that harbour variants associated with major ...
Zachary F Gerring, Eric R Gamazon, Eske M Derks, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium   +3 more
doaj   +1 more source

Serum level of soluble interleukin 6 receptor is a useful biomarker for identification of treatment‐resistant major depressive disorder

Neuropsychopharmacology Reports, 2020
Aim A substantial proportion of major depressive disorder patients are treatment‐resistant to antidepressant therapy, who require augmentation drugs, or other treatments including electroconvulsive therapy or transcranial magnetic stimulation ...
Katsuhiko Yamasaki, Tomonori Hasegawa, Masatoshi Takeda   +2 more
doaj   +1 more source

Do Suicide Attempts of Mood Disorder Patients Directly Increase the Risk for a Reattempt?

Frontiers in Psychiatry, 2020
Background: Preceding suicide attempts strongly predict future suicidal acts. However, whether attempting suicide per se increases the risk remains undetermined.
Kari I. Aaltonen, Kari I. Aaltonen, Tom Rosenström, Tom Rosenström, Pekka Jylhä, Pekka Jylhä, Irina Holma, Irina Holma, Mikael Holma, Mikael Holma, Sanna Pallaskorpi, Sanna Pallaskorpi, Kirsi Riihimäki, Kirsi Suominen, Maria Vuorilehto, Maria Vuorilehto, Erkki T. Isometsä, Erkki T. Isometsä   +17 more
doaj   +1 more source