Results 21 to 30 of about 6,214,949 (261)

Patient-reported outcomes in major depressive disorder with suicidal ideation: a real-world data analysis using PatientsLikeMe platform

BMC Psychiatry, 2020
Background The current analysis utilized data collected via an online patient community platform, PatientsLikeMe (PLM) to compare patient-reported experiences in patients with major depressive disorder (MDD) with suicidal ideation (MDSI) to those with ...
Stephane Borentain, Abigail I. Nash, Rachna Dayal, Allitia DiBernardo   +3 more
doaj   +1 more source

Depression from the perspective of modern and Persian medicine

Electronic Physician, 2018
Background: Depression is one of the five most-common diseases globally, and is expected to be the second leading cause of disability by 2020 and its economic and social burden is a major problem worldwide Objective: The aim of this research was to ...
Majid Anushiravani, Ali Akhondpour Manteghi, Ali Taghipur, Mahdi Eslami   +3 more
doaj   +1 more source

Epidemiology and heritability of Major Depressive Disorder, stratified by age of onset, sex, and illness course in Generation Scotland:Scottish Family Health Study (GS:SFHS) [PDF]

, 2015
The heritability of Major Depressive Disorder (MDD) has been estimated at 37% based largely on twin studies that rely on contested assumptions. More recently, the heritability of MDD has been estimated on large populations from registries such as the ...
Andrew G. McKechanie (827281), Ana Maria Fernandez-Pujals, Mark James Adams (3272922), Matthews Keith, Chris S Haley, Mark James Adams, Morris, Andrew D., Morris, Andrew D, Pippa Thomson, Campbell Archie, MacIntyre, Donald J; id_orcid, Anna F Dominiczak, MacIntyre Donald J., Andrew G McKechanie, Andrew M McIntosh, Ana Maria Fernandez-Pujals (827280), Thomson, Pippa; id_orcid, Fernandez-Pujals, Ana Maria, Pippa Thomson (759189), MacIntyre, Donald J., McIntosh Andrew M., Pamela Linksted (787794), David J Porteous, Adams, Mark James; id_orcid, Campbell, Archie, Chris S. Haley (208845), Keith Matthews (22202), Morris Andrew D., Smith, Blair H.; id_orcid, Andrew M. McIntosh (292147), Blackwood, Douglas H R, David J. Porteous (107720), Ian J. Deary (107724), Andrew D Morris, Andrew D. Morris (130204), Matthews, Keith, Haley, Chris S., Adams, Mark James, McKechanie, Andrew G; id_orcid, Deary, Ian J., Smith Blair H., Porteous, David J, Ian J Deary, McKechanie, Andrew G., Blair H Smith, Thomson, Pippa, Blackwood, Douglas H. R., Smith, Blair H, Donald J. MacIntyre (827282), Linksted Pamela, McIntosh, Andrew M., Archie Campbell (669891), Ebmeier, Klaus, McIntosh, Andrew M; id_orcid, Archie Campbell, Deary, Ian J, Douglas H. R. Blackwood (759192), McKechanie Andrew G., Blair H. Smith (625812), Fernandez-Pujals Ana Maria, Keith Matthews, Linksted, Pamela, Anna F. Dominiczak (238664), Blackwood Douglas H. R., Smith, Blair H., Porteous, David J., Dominiczak, Anna F, Haley, Chris S, Dominiczak, Anna, Haley Chris S., Deary Ian J., Donald J MacIntyre, Thomson Pippa, Pamela Linksted, Dominiczak, Anna F., Porteous David J., Douglas H R Blackwood, Adams Mark James, Dominiczak Anna F.   +78 more
core   +1 more source

Neurobiology of Major Depressive Disorder

Neural Plasticity, 2013
We survey studies which relate abnormal neurogenesis to major depressive disorder. Clinically, descriptive gene and protein expression analysis and genetic and functional studies revised here show that individual alterations of a complex signaling ...
Rosa Villanueva
doaj   +1 more source

Retinoid homeostasis in major depressive disorder

Translational Psychiatry, 2023
The small, hormone-like molecule retinoic acid (RA) is a vital regulator in several neurobiological processes that are affected in depression. Next to its involvement in dopaminergic signal transduction, neuroinflammation, and neuroendocrine regulation ...
Lisa Rebecca Otto, Vera Clemens, Berk Üsekes, Nicoleta Carmen Cosma, Francesca Regen, Julian Hellmann-Regen   +5 more
doaj   +1 more source

Non-REM sleep in major depressive disorder

NeuroImage: Clinical, 2022
Disturbed sleep is a key symptom in major depressive disorder (MDD). REM sleep alterations are well described in the current literature, but little is known about non-REM sleep alterations.
Leonore Bovy, Frederik D. Weber, Indira Tendolkar, Guillén Fernández, Michael Czisch, Axel Steiger, Marcel Zeising, Martin Dresler   +7 more
doaj   +1 more source

Immature defense mechanisms predict poor response to psychotherapy in major depressive patients with comorbid cluster B personality disorder

Brazilian Journal of Psychiatry, 2022
Objective: To evaluate the impact of defense mechanisms at baseline on depressive symptoms after brief psychotherapies and after 6-months of follow-up among depressed patients with and without cluster B personality disorders (PDs).
Carolina Rheingantz Scaini, Igor Soares Vieira, Rosiene Machado, Taiane de Azevedo Cardoso, Thaise Mondin, Luciano Souza, Mariane Lopez Molina, Karen Jansen, Ricardo Azevedo da Silva   +8 more
doaj   +1 more source

Using polygenic scores and clinical data for bipolar disorder patient stratification and lithium response prediction: machine learning approach

, 2022
Background Response to lithium in patients with bipolar disorder is associated with clinical and transdiagnostic genetic factors. The predictive combination of these variables might help clinicians better predict which patients will respond to lithium ...
Streit, Fabian, Ardau, Raffaella, the Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Akula, Nirmala, Cearns, Micah, Akiyama, Kazufumi, Frank, Joseph, Thalamuthu, Anbupalam, Adli, Mazda, Amare, Azmeraw T., Baune, Bernhard T., Schubert, Klaus Oliver   +11 more
core   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Neurocognitive, School‐Based, and Quality of Life Outcomes for Youth With Sickle Cell Disease and Thalassemia: A Scoping Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT The medical burdens of sickle cell disease (SCD) and transfusion‐dependent β‐thalassemia (TDT) are chronic and cumulative, even in children. Yet the effects expand beyond medications and healthcare visits due to their impacts on school attendance, academic performance, and peer engagement.
Mary Ann Etling, Hakim Tokhi, Alexander A. Boucher   +2 more
wiley   +1 more source