Results 241 to 250 of about 242,210 (352)

Unraveling the architecture of major histocompatibility complex class II haplotypes in rhesus macaques. [PDF]

Genome Res
de Groot N, van der Wiel M, Le NG, de Groot NG, Bruijnesteijn J, Bontrop RE.   +5 more
europepmc   +1 more source

Biomolecular Interaction Prediction in the Pre‐ and Post‐AlphaFold Era: The 8th CAPRI Evaluation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT We report on the 8th CAPRI Evaluation period, capturing the assessment of CAPRI Rounds 47 to 55 (excluding the CASP and COVID‐related Rounds), which have witnessed the transition to AI‐driven prediction tools such as AlphaFold and related alternatives. The prediction Rounds in this evaluation are characterized by a high level of difficulty due
Marc F. Lensink, Nessim Raouraoua, Guillaume Brysbaert, Sameer Velankar, Shoshana J. Wodak, Alexandre M. J. J. Bonvin   +5 more
wiley   +1 more source

Palaeognaths Reveal Evolutionary Ancestry of the Avian Major Histocompatibility Complex Class II. [PDF]

Genome Biol Evol
Minias P, Babik W.
europepmc   +1 more source

Rationalizing Enhanced Affinity of Engineered T‐Cell Receptors in Cancer Immunotherapy Through Interaction Energy Calculations and Residue Correlation Analysis

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The advancement of T cell engineering has significantly transformed the field of cancer immunotherapy. In particular, T cells equipped with modified T cell receptors present a promising therapeutic strategy, especially for addressing solid tumors.
Mario Frezzini, Daniele Narzi
wiley   +1 more source

Prognostic development and validation of a prediction model based on major histocompatibility complex-related differentially expressed genes in stomach adenocarcinoma. [PDF]

Transl Cancer Res
Wang T, Liu Y, Ma S, Qiu B, Wang Q.
europepmc   +1 more source

Occupancy of upstream regulatory sites in vivo coincides with major histocompatibility complex class I gene expression in mouse tissues.

, 1992
Anup Dey, Angela M. Thornton, M Lonergan, S M Weissman, J W Chamberlain, Keiko Ozato   +5 more
openalex   +2 more sources

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

Widespread Adaptive Introgression of Major Histocompatibility Complex Genes across Vertebrate Hybrid Zones. [PDF]

Mol Biol Evol
Gaczorek T, Dudek K, Fritz U, Bahri-Sfar L, Baird SJE, Bonhomme F, Dufresnes C, Gvoždík V, Irwin D, Kotlík P, Marková S, McGinnity P, Migalska M, Moravec J, Natola L, Pabijan M, Phillips KP, Schöneberg Y, Souissi A, Radwan J, Babik W.   +20 more
europepmc   +1 more source

Rejection of B16 melanoma induced by expression of a transfected major histocompatibility complex class I gene.

, 1988
Kenichi Tanaka, E Gorelik, Motoo Watanabe, Nobumichi Hozumi, Gregory D. Jay   +4 more
openalex   +2 more sources

Mathematical Modeling of Neuroinflammation in Neurodegenerative Diseases

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Age‐related neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD) and Parkinson's disease (PD) are an increasing public health concern. Whereas the pathology of these diseases is complex, chronic central inflammation, or neuroinflammation, is commonly observed across many neurodegenerative diseases ...
Alex Foster‐Powell, Amin Rostami‐Hodjegan, Guy Meno‐Tetang, Donald E. Mager, Kayode Ogungbenro   +4 more
wiley   +1 more source