Results 261 to 270 of about 235,574 (356)

Humanized Major Histocompatibility Complex Transgenic Mouse Model Can Play a Potent Role in SARS-CoV-2 Human Leukocyte Antigen-Restricted T Cell Epitope Screening. [PDF]

Vaccines (Basel)
Zhang J, Fang F, Zhang Y, Han X, Wang Y, Yin Q, Sun K, Zhou H, Qin H, Zhao D, Tai W, Zhang J, Zhang Z, Yang T, Wei Y, Zhang S, Li S, Li M, Zhao G.   +18 more
europepmc   +1 more source

Artificial Intelligence and the Evolving Landscape of Immunopeptidomics

PROTEOMICS – Clinical Applications, EarlyView.
ABSTRACT Background Immunopeptidomics is the large‐scale study of peptides presented by major histocompatibility complex (MHC) molecules and plays a central role in neoantigen discovery and cancer immunotherapy. However, the complexity of mass spectrometry data, the diversity of peptide sources, and variability in immune responses present major ...
Thanh Hoa Vo, Edel McNeela, Orla O'Donovan, Sweta Rani, Jai Prakash Mehta   +4 more
wiley   +1 more source

Omega-3 EPA Supplementation Shapes the Gut Microbiota Composition and Reduces Major Histocompatibility Complex Class II in Aged Wild-Type and APP/PS1 Alzheimer's Mice: A Pilot Experimental Study. [PDF]

Nutrients
Altendorfer B, Benedetti A, Mrowetz H, Bernegger S, Bretl A, Preishuber-Pflügl J, Bessa de Sousa DM, Ladek AM, Koller A, Le Faouder P, Bertrand-Michel J, Trost A, Aigner L.   +12 more
europepmc   +1 more source

Integrative Modeling in the Age of Machine Learning: A Summary of HADDOCK Strategies in CAPRI Rounds 47–55

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The HADDOCK team participated in CAPRI rounds 47–55 as server, manual predictor, and scorers. Throughout these CAPRI rounds, we used a plethora of computational strategies to predict the structure of protein complexes. Of the 10 targets comprising 24 interfaces, we achieved acceptable or better models for 3 targets in the human category and 1 ...
Victor Reys, Marco Giulini, Vlad Cojocaru, Anna Engel, Xiaotong Xu, Jorge Roel‐Touris, Cunliang Geng, Francesco Ambrosetti, Brian Jiménez‐García, Zuzana Jandova, Panagiotis I. Koukos, Charlotte van Noort, João M. C. Teixeira, Siri C. van Keulen, Manon Réau, Rodrigo V. Honorato, Alexandre M. J. J. Bonvin   +16 more
wiley   +1 more source

A combination of major histocompatibility complex (MHC) I overexpression and type I interferon induce mitochondrial dysfunction in human skeletal myoblasts. [PDF]

J Cell Physiol
Thoma A, Alomosh R, Bond HL, Akter-Miah T, Al-Shanti N, Degens H, Pekovic-Vaughan V, Lightfoot AP.   +7 more
europepmc   +1 more source

Trans-acting element(s) operating across species barriers positively regulate expression of major histocompatibility complex class II genes.

, 1985
Roberto S. Accolla, Léonardo Scarpellino, Giovanna Carrà, John Guardiola   +3 more
openalex   +1 more source

Massive Sampling Strategy for Antibody–Antigen Targets in CAPRI Round 55 With MassiveFold

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Massive sampling with AlphaFold2 improves protein–protein complex predictions. This has been shown during the last CASP15‐CAPRI blind prediction round by the AFsample tool. However, more difficult targets including antibody–antigen binding remain challenging. CAPRI Round 55 consisted of three antibody–antigen targets and one heterotrimer.
Nessim Raouraoua, Marc F. Lensink, Guillaume Brysbaert   +2 more
wiley   +1 more source

Organisation and evolution of the major histocompatibility complex class I genes in cetaceans. [PDF]

iScience
Day G, Robb K, Oxley A, Telonis-Scott M, Ujvari B.   +4 more
europepmc   +1 more source

Class II genes of the human major histocompatibility complex. Evolution of the DP region as deduced from nucleotide sequences of the four genes.

, 1987
Kenth Gustafsson, E Widmark, Ann-Kristin Jonsson, B Servenius, D H Sachs, Dan Larhammar, Lars Rask, P A Peterson   +7 more
openalex   +1 more source

Biomolecular Interaction Prediction in the Pre‐ and Post‐AlphaFold Era: The 8th CAPRI Evaluation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT We report on the 8th CAPRI Evaluation period, capturing the assessment of CAPRI Rounds 47 to 55 (excluding the CASP and COVID‐related Rounds), which have witnessed the transition to AI‐driven prediction tools such as AlphaFold and related alternatives. The prediction Rounds in this evaluation are characterized by a high level of difficulty due
Marc F. Lensink, Nessim Raouraoua, Guillaume Brysbaert, Sameer Velankar, Shoshana J. Wodak, Alexandre M. J. J. Bonvin   +5 more
wiley   +1 more source