Results 271 to 280 of about 235,574 (356)

Identification of new major histocompatibility complex-B Haplotypes in Bangladesh native chickens. [PDF]

Anim Biosci
Ediriweera TK, Manjula P, Kim J, Kim JH, Nam S, Kim M, Cho E, Bhuiyan MSA, Rashid MA, Lee JH.   +9 more
europepmc   +1 more source

Rationalizing Enhanced Affinity of Engineered T‐Cell Receptors in Cancer Immunotherapy Through Interaction Energy Calculations and Residue Correlation Analysis

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The advancement of T cell engineering has significantly transformed the field of cancer immunotherapy. In particular, T cells equipped with modified T cell receptors present a promising therapeutic strategy, especially for addressing solid tumors.
Mario Frezzini, Daniele Narzi
wiley   +1 more source

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

Novel Presentation of Major Histocompatibility Complex Class II Deficiency with Hemophagocytic Lymphohistiocytosis. [PDF]

J Clin Immunol
Alroqi FJ, Alhezam MA, Almojali AI, Barhoumi T, Althubaiti N, Alharbi Y, Al Balwi MA, Alrasheed A.   +7 more
europepmc   +1 more source

Mathematical Modeling of Neuroinflammation in Neurodegenerative Diseases

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Age‐related neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD) and Parkinson's disease (PD) are an increasing public health concern. Whereas the pathology of these diseases is complex, chronic central inflammation, or neuroinflammation, is commonly observed across many neurodegenerative diseases ...
Alex Foster‐Powell, Amin Rostami‐Hodjegan, Guy Meno‐Tetang, Donald E. Mager, Kayode Ogungbenro   +4 more
wiley   +1 more source

Glutamate Signaling and Neuroligin/Neurexin Adhesion Play Opposing Roles That Are Mediated by Major Histocompatibility Complex I Molecules in Cortical Synapse Formation. [PDF]

J Neurosci
Sell GL, Barrow SL, McAllister AK.
europepmc   +1 more source

Advances in Atopic Dermatitis Treatment: From Pathogenesis to Natural Product‐Based Therapies

Phytotherapy Research, EarlyView.
NPs improve atopic dermatitis mainly include flavonoids, phenols, glycosides, alkaloids, and others. ABSTRACT Atopic dermatitis (AD), a widespread and chronic inflammatory skin disorder, profoundly affects patients' quality of life, imposes significant psychological strain, and adds to the public health burden.
Xinyun Fan, Zibo Liu, Wenjing Yang, Hongying Zhang, Hao Zhong, Yan Pang, Xun Ye, Chunjie Wu, Liang Li   +8 more
wiley   +1 more source

A New Look at Immunogenetics of Pregnancy: Maternal Major Histocompatibility Complex Class I Educates Uterine Natural Killer Cells. [PDF]

Int J Mol Sci
Bos M, Colucci F.
europepmc   +1 more source

Clinical perspectives and comparisons between immunoglobulin G4‐related disease and antineutrophil cytoplasmic antibody‐associated vasculitis

Rheumatology &Autoimmunity, EarlyView.
Clinical perspectives and comparisons between immunoglobulin G4‐related disease and antineutrophil cytoplasmic antibody‐associated vasculitis. Abstract Both immunoglobulin (Ig) G4‐related disease (IgG4‐RD) and antineutrophil cytoplasmic antibody (ANCA)‐associated vasculitis (AAV) are systemic disorders that affect a wide range of organs.
Wenhuan Zeng, Mingxin Bai, Yanying Liu
wiley   +1 more source

Complex Interactions between the Human Major Histocompatibility Complex (MHC) and Microbiota: Their Roles in Disease Pathogenesis and Immune System Regulation. [PDF]

Biomedicines
Arnaiz-Villena A, Juarez I, Vaquero-Yuste C, Lledo T, Martin-Villa JM, Suarez-Trujillo F.   +5 more
europepmc   +1 more source