Results 281 to 290 of about 235,574 (356)

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Deep analysis of the major histocompatibility complex genetic associations using covariate analysis and haploblocks unravels new mechanisms for the molecular etiology of Elite Control in AIDS. [PDF]

BMC Immunol
Rahmouni M, Clerc SL, Spadoni JL, Labib T, Tison M, Medina-Santos R, Bensussan A, Tamouza R, Deleuze JF, Zagury JF.   +9 more
europepmc   +1 more source

Passivation‐Engineered Zinc Peroxide Nanoparticles as Th1‐Biased Adjuvant for Antitumor Immunity

Small, EarlyView.
This study demonstrates passivated zinc peroxide nanoparticles (p‐ZPNs) as a novel class of Th1‐biased adjuvants to boost the efficacy of cancer vaccines. The p‐ZPNs exhibit excellent cellular uptake, low cytotoxicity, efficient endosome escape and intrinsic capability for triggering TLR/MyD88/NF‐κB axis, leading to robust T cell immunity.
Jiangqi Luo, Yue Wang, Zan Dai, Yiru Shi, Weixi Wu, Jingjing Qu, Yuening Zhong, Jianqiao Xian, Chengzhong Yu, Yannan Yang   +9 more
wiley   +1 more source

Programmed Cell Death Ligand 1 (PD-L1) and Major Histocompatibility Complex Class I (MHC Class I) Expression Patterns and Their Pathologic Associations in Triple-Negative Breast Cancer. [PDF]

Breast Cancer (Dove Med Press)
Kaewkedsri P, Intarawichian P, Jessadapattarakul S, Kunprom W, Koonmee S, Thanee M, Somintara O, Wongbuddha A, Chadbunchachai P, Nawapun S, Aphivatanasiri C.   +10 more
europepmc   +1 more source

CRISPR/Cas9‐edited tumor‐associated immune cells in cancer immunotherapy

VIEW, EarlyView.
Abstract Immuno‐oncology represents an emerging field that has significantly transformed tumor therapeutics, with immune cells serving as the cellular foundations of cancer immunotherapy. Due to its high efficiency and sensitivity, CRISPR/Cas9 genome editing is a highly promising technique for precise and rapid gene modification.
Yuhui Ma, Junxin Chen, Yuan Du, Zhihao Cao, Weizhi Ji, Yuyu Niu, Zebin Yang   +6 more
wiley   +1 more source

Common risk alleles for schizophrenia within the major histocompatibility complex predict white matter microstructure. [PDF]

Transl Psychiatry
Caseras X, Simmonds E, Pardiñas AF, Anney R, Legge SE, Walters JTR, Harrison NA, O'Donovan MC, Escott-Price V.   +8 more
europepmc   +1 more source

Single‐cell spatial transcriptomic sequencing and machine learning models uncover molecular mechanisms and diagnostic biomarkers of Peyronie's disease formation in rats

VIEW, EarlyView.
Peyronie's disease (PD) is a common male reproductive system disorder. The exact etiology of PD remains unclear. This study aimed to investigate molecular and cellular changes in PD using single‐cell spatial transcriptomics. Abstract Peyronie's disease (PD), commonly known as penile induration, is a prevalent male reproductive system disorder with ...
Keyuan Lou, Qiancheng Mao, Junpeng Chi, Jiankun Zhang, Hao Guo, Jitao Wu, Yuanshan Cui   +6 more
wiley   +1 more source

An integrated database of experimentally validated major histocompatibility complex epitopes for antigen-specific cancer therapy. [PDF]

Antib Ther
Kawakita S, Shen A, Chao CC, Wang Z, Cheng S, Li B, Jiang C.   +6 more
europepmc   +1 more source

ESTABLISHMENT OF PRIMARY CULTURES OF HUMAN BILIARY EPITHELIUM AND INDUCTION OF CLASS-II MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS BY INTERFERON-GAMMA [PDF]

, 1988
DEMETRIS, AJ, DUQUESNOY, R, FUNG, J, MAKOWKA, L, MARKUS, B, SAIDMAN, S, STARZL, TE   +6 more
core  

Integrative Analysis of Plasma Proteome and Genome Reveals Novel Drug Targets for Chronic Rhinosinusitis and Nasal Polyps

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) and nasal polyps (NP) are chronic inflammatory conditions with unsatisfactory treatment outcomes due to frequent recurrence of refractory disease. Identifying new therapeutic targets is essential. Methods We conducted a proteome‐wide Mendelian randomization (MR) analysis by integrating genome‐wide ...
En Zhou, Shi Luo, Yu Xiao, Bin Liu, Xu‐Ping Xiao   +4 more
wiley   +1 more source