Results 311 to 320 of about 235,574 (356)
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The Major Histocompatibility Complex
1987The basis of all immunological activity is interaction between members of different populations which constitute the lymphoid system. When one cell touches another, it responds according to its own state and its interpretation of the identity and state of the other.
Ian J. Forbes, Anthony S-Y. Leong
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The major histocompatibility complex of primates
Genetica, 1987The major histocompatibility complex (MHC) encodes cell surface glycoproteins that function in self-nonself recognition and in allograft rejection. Among primates, the MHC has been well defined only in the human; in the chimpanzee and in two species of macaque monkeys the MHC is less well characterized.
Douglas J. Cook +6 more
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Porcine major histocompatibility complex
Revue Scientifique et Technique de l'OIE, 1998The major histocompatibility complex in swine (swine leucocyte antigen: SLA) is located on chromosome 7 with the class I and class III regions separated by the centromere from the class II region. The overall molecular organisation of the class I and III regions is well known, but further research is needed to establish that of the class II region ...
Vaiman, M. +2 more
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Major histocompatibility complex, t-complex, and leukemia
Cancer Causes and Control, 1992In experimental models, leukemia was the first disease shown to have an association with the major histocompatibility complex (MHC) genes. In humans, several allelic human-leukocyte antigen (HLA) associations also have been recognized. In addition to allelic associations, atypical HLA segregation patterns have been observed in leukemic families.
Burnett Ak, Dorak Mt
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The Nature of Selection on the Major Histocompatibility Complex
Critical Reviews™ in Immunology, 1997Only natural selection can account for the extreme genetic diversity of genes of the major histocompatibility complex (MHC). Although the structure and function of classic MHC genes is well understood at the molecular and cellular levels, there is controversy about how MHC diversity is selectively maintained. The diversifying selection can be driven by
Patricia R. Slev +4 more
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The Major Histocompatibility Complex
2015The major histocompatibility complex (MHC) proteins display peptides on the surface of an antigen-presenting cell (APC). Since T lymphocytes recognize antigen only when the antigen is bound to MHC proteins, the latter play a central role in the acquired immune response.
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The major histocompatibility complex in fish
Revue Scientifique et Technique de l'OIE, 1998The first major histocompatibility complex (MHC) molecule in fish was identified in 1990 using a polymerase chain reaction strategy with degenerate primers (thereby avoiding the problem of low sequence similarity between higher vertebrates and fish).
Lie O, Grimholt Y
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Major Histocompatibility Complex
1999The first recognition of MHC genes was based on their ability to encode proteins that serve as identity markers on tissues and cells that have been transplanted into an incompatible recipient. Their recognition by the recipient’s lymphocytes leads to prompt rejection.
Julius M. Cruse, Robert E. Lewis
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The Marsupial Major Histocompatibility Complex
2010The major histocompatibility complex (MHC) contains genes that play essential roles in the innate and adaptive immune responses, and has been one of the most studied genomic regions among vertebrates. The marsupial MHC has been intensively investigated in several species, with the genomic organization having been characterized in the gray short-tailed ...
Cheng, Yuanyuan +2 more
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The major histocompatibility complex
1993It has long been known that the fate of transplanted foreign cells, tissues and organs depends on genetic factors. Basic experiments concerning this problem were performed in laboratory animals, particularly in mice. The genetic basis of tissue incompatibility (histoincompatibility) was demonstrated in inbred animal strains.
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