Results 81 to 90 of about 239,963 (355)

Discovery of a Novel MHC Class I Lineage in Teleost Fish which Shows Unprecedented Levels of Ectodomain Deterioration while Possessing an Impressive Cytoplasmic Tail Motif

Cells, 2019
A unique new nonclassical MHC class I lineage was found in Teleostei (teleosts, modern bony fish, e.g., zebrafish) and Holostei (a group of primitive bony fish, e.g., spotted gar), which was designated “H” (from “hexa”) for being ...
Unni Grimholt, Kentaro Tsukamoto, Keiichiro Hashimoto, Johannes M. Dijkstra   +3 more
doaj   +1 more source

The peptide motif of the single dominantly expressed class I molecule of the chicken MHC can explain the response to a molecular defined vaccine of infectious bursal disease virus (IBDV) [PDF]

, 2013
In contrast to typical mammals, the chicken MHC (the BF-BL region of the B locus) has strong genetic associations with resistance and susceptibility to infectious pathogens as well as responses to vaccines.
Butter, Colin, Davison, T. Fred, Kaufman, Jim, Staines, Karen, van Hateren, Andrew   +4 more
core   +1 more source

Spatial Transcriptional Dynamics of CD74⁺ B Cells in Tertiary Lymphoid Structures Drive Immune Evolution in Penile Squamous Cell Carcinoma

Advanced Science, EarlyView.
In penile squamous cell carcinoma, a higher tertiary lymphoid structure score is associated with improved survival. This is mediated by CD74⁺ B cells, which exhibit early developmental plasticity and the ability to differentiate into plasma cells. Functioning as a molecular switch, these cells activate naive T cells via HLA‐DRA–CD4 interaction, thereby
Ting Xue, Chuangzhong Deng, Jingya Liu, Ru Yan, Jing Li, Xiheng Hu, Xueying Li, Xiao Xiao, Jietian Jin, Hongzhen Tang, Desi Chen, Zihan Zuo, Yujie Liang, Dongbin Wang, Bonan Chen, Hui Han, Zaishang Li   +16 more
wiley   +1 more source

USMPep: universal sequence models for major histocompatibility complex binding affinity prediction

BMC Bioinformatics, 2020
Background Immunotherapy is a promising route towards personalized cancer treatment. A key algorithmic challenge in this process is to decide if a given peptide (neoepitope) binds with the major histocompatibility complex (MHC). This is an active area of
Johanna Vielhaben, Markus Wenzel, Wojciech Samek, Nils Strodthoff   +3 more
doaj   +1 more source

Mechanically Active Hydrogel for Healing Intestinal Fistulas through the YAP‐Mediated Mechanosensitization of Intestinal Epithelial Cells

Advanced Science, EarlyView.
This study develops the hydrogel with antimicrobial, adhesive, degradable, injectable, and temperature‐sensitive contraction properties based on the transcriptomic and pathological characteristics of intestinal fistula patients. This hydrogel can seal rabbit intestinal fistula in situ, reduce the intestinal defect, and promote intestinal epithelial ...
Ze Li, Jiayang Li, Kang Chen, Guiwen Qu, Shuanghong Yang, Sicheng Li, Ye Liu, Yitian Teng, Rui Ma, Jinjian Huang, Peige Wang, Jianan Ren, Xiuwen Wu   +12 more
wiley   +1 more source

Major Histocompatibility Complex (MHC) Genes and Disease Resistance in Fish

Cells, 2019
Fascinating about classical major histocompatibility complex (MHC) molecules is their polymorphism. The present study is a review and discussion of the fish MHC situation. The basic pattern of MHC variation in fish is similar to mammals, with MHC class I
Takuya Yamaguchi, Johannes M. Dijkstra
doaj   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Major Histocompatibility Complex and Malaria: Focus on Plasmodium vivax infection

Frontiers in Immunology, 2016
The importance of host and parasite genetic factors in malaria resistance or susceptibility has been investigated since the middle of the last century. Nowadays, of all diseases that affect man, malaria still plays one of the highest levels of selective ...
Josué Costa Lima-Junior, Lilian Rose Pratt-Riccio   +1 more
doaj   +1 more source

MHC-linked and un-linked class I genes in the wallaby [PDF]

, 2009
Background: MHC class I antigens are encoded by a rapidly evolving gene family comprising classical and non-classical genes that are found in all vertebrates and involved in diverse immune functions.
Beck, S., Belov, K., Cheng, Y., Coggill, P., Deakin, J.E., Harrow, J., Hart, E., Siddle, H.V., Wong, E.S.W.   +8 more
core   +4 more sources

Mechanotransduction in Shaping Immunity: Pathways, Crosstalk, and Pathophysiological Relevance

Advanced Science, EarlyView.
This review comprehensively summarizes the role of mechanotransduction in shaping immunity. It details how immune cells respond to biomechanical cues via mechanotransduction cascades and emphasizes the mechanical crosstalks within the immune microenvironment. The emerging significance of mechanoimmunology in both health and diseases is also highlighted.
Ruijiao Yan, Yuyu Li, Shuo Chen, Li Zhu, Chenchen Zhou, Jianwei Chen, Shujuan Zou, Xianglong Han   +7 more
wiley   +1 more source