Results 81 to 90 of about 991,100 (420)
Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value
Molecular Oncology, EarlyView.The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song +13 more
wiley +1 more source
Journal of Veterinary Research, 2017 Introduction: Pregnancy is a physiological state in which the immune system undergoes certain changes. On the one hand, by depleting cell defence mechanisms, it favours development and maintenance of the pregnancy.
Krakowski Leszek +6 more
doaj +1 more source
Exploration of the Conformational Dynamics of Major Histocompatibility Complex Molecules
Frontiers in Immunology, 2017 Major histocompatibility complex (MHC) molecules are loaded with a wide variety of self- and non-self-peptides in their binding grooves and present these to T cell receptors (TCRs) in order to activate the adaptive immune system.
Saeko Yanaka, Kenji Sugase
doaj +1 more source
PredMHC: An Effective Predictor of Major Histocompatibility Complex Using Mixed Features
Frontiers in Genetics, 2022 The major histocompatibility complex (MHC) is a large locus on vertebrate DNA that contains a tightly linked set of polymorphic genes encoding cell surface proteins essential for the adaptive immune system.
Dong Chen, Yanjuan Li
doaj +1 more source
The major histocompatibility complex: a model for understanding graft-versus-host disease.
Blood, 2013 Acute graft-versus-host disease (GVHD) afflicts as much as 80% of all patients who receive an unrelated donor hematopoietic cell transplant (HCT) for the treatment of blood disorders, even with optimal donor HLA matching and use of prophylactic ...
E. Petersdorf
semanticscholar +1 more source
Major histocompatibility complex haplotype diversity in Arab horses from Argentina [PDF]
, 2017 La diversidad de los genes del complejo principal de histocompatibilidad (MHC) es clave en su función en la presentación de antígenos en el sistema inmune.
Carino, Mónica Herminia +6 more
core +3 more sources
The roles and applications of extracellular vesicles in cancer
Molecular Oncology, EarlyView.Extracellular vesicles (EVs) are minute versions of cells limited by a lipid bilayer containing cytoplasm from the cell that releases them, but without a nucleus and thus unable to self‐reproduce. EVs contain multiple molecules (proteins, lipids, glycans, and nucleic acids) they can induce complex responses in cells.
Clotilde Théry, Daniel Louvard
wiley +1 more source
Haplessly hoping: macaque major histocompatibility complex made easy.
ILAR journal, 2013 Major histocompatibility complex (MHC) gene products control the repertoire of T cell responses that an individual may create against pathogens and foreign tissues.
R. Wiseman +5 more
semanticscholar +1 more source
THE MAJOR HISTOCOMPATIBILITY COMPLEX: A REVIEW [PDF]
, 2017 One of the important components of the immune system, the major histocompatibility complex (MHC) molecules allow T-lymphocytes to detect cells, such as macrophages, B-lymphocytes, and dendritic cells that ingest infectious microorganisms or the self ...
Kumar, Pradeep +2 more
core +1 more source
FEBS Open Bio, EarlyView.The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik +3 more
wiley +1 more source