Results 221 to 230 of about 1,544,255 (266)

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Majorizing sequences for iterative procedures in Banach spaces [PDF]

Journal of Complexity, 2012
The article deals with Newton-like approximations \[ x_{n+1} = x_n - A(x_n)^{-1}(F(x_n) + G(x_n)), \quad n = 0,1,2,\ldots,\tag{1} \] to a nonlinear operator equation \[ F(x) + G(x) = 0 \] with a Fréchet differentiable operator \(F\) and a continuous operator \(G\); here \(A(x)\) are linear operators with the invertible \(A(x_0)\).
Ioannis K Argyros, Said Hilout
exaly   +4 more sources

Estimates of majorizing sequences in the Newton–Kantorovich method: A further improvement [PDF]

Journal of Mathematical Analysis and Applications, 2006
Let f:B(x0,R)⊆X→Y be an operator, with X and Y Banach spaces, and f′ be Hölder continuous with exponent θ. The convergence of the sequence of Newton–Kantorovich approximationsxn=xn−1−f′(xn−1)−1f(xn−1),n∈N, is a classical tool to solve the equation f(x)=0.
Filomena Cianciaruso, Espedito de Pascale   +1 more
exaly   +2 more sources

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Construction of simple majorizing sequences for iterative methods

Applied Mathematics Letters, 2019
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
José Antonio Ezquerro Fernández, M A Hernández-Verón   +1 more
exaly   +2 more sources

Estimates of Majorizing Sequences in the Newton–Kantorovich Method

Numerical Functional Analysis and Optimization, 2006
Let f:B(x 0,R) ⊆ X → Y be an operator, with X and Y Banach spaces, and f′ be Holder continuous with exponent θ. The convergence of the sequence of Newton–Kantorovich approximations is a classical tool to solve the equation f(x) = 0. The convergence of x n is often reduced to the study of the majorizing sequence r n defined by with a, b, k parameters ...
Filomena Cianciaruso, Espedito de Pascale   +1 more
exaly   +3 more sources

Sequence microheterogeneity of parvalbumin, the major fish allergen

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2013
The microheterogeneity of amino acid sequence observed in various allergens may affect immune response, but incidence of sequence microheterogeneity in allergens and its relation to their allergenicity are unclear. The occurrence of sequence microheterogeneity in major fish allergen, parvalbumin (PA), has been explored using bioinformatics approaches ...
Lapteva, Yulia S., Uversky, Vladimir N., Permyakov, Sergei E.   +2 more
openaire   +3 more sources

Power Majorization and Majorization of Sequences

Results in Mathematics, 1988
Let \(x,y\in R^ n_+\) be such that \(x_ 1\geq...\geq x_ n\), \(y_ 1\geq...\geq y_ n\) and \(\sum x_ i=\sum y_ i.\) We say that x is power majorized by y if \(\sum x^ p_ i\leq \sum y^ p_ i\) for all real \(p\not\in [0,1]\) and \(\sum x^ p_ i\geq \sum y^ p_ i\) for \(p\in [0,1]\). Let \(\phi\) : [0,\(\infty)\to R\) be a continuous function.
openaire   +1 more source