Results 91 to 100 of about 293 (242)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The genomic sequence and analysis of the swine major histocompatibility complex

Genomics, 2006
We describe the generation and analysis of an integrated sequence map of a 2.4-Mb region of pig chromosome 7, comprising the classical class I region, the extended and classical class II regions, and the class III region of the major histocompatibility complex (MHC), also known as swine leukocyte antigen (SLA) complex.
Renard, Christine, Hart, E., Sehra, H., Beasley, H., Coggil, P., Howe, K., Harrow, J., Gilbert, Jean-Charles, Sims, S., Rogers, J., Ando, A., Shinegari, A., Shiina, T., Inoko, H., Chardon, Patrick, Beck, S.   +15 more
openaire   +3 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Extending the Applicability of Newton-Jarratt-like Methods with Accelerators of Order 2m + 1 for Solving Nonlinear Systems

Axioms
The local convergence analysis of the m+1-step Newton-Jarratt composite scheme with order 2m+1 has been shown previously. But the convergence order 2m+1 is obtained using Taylor series and assumptions on the existence of at least the fifth derivative of ...
Ioannis K. Argyros, Stepan Shakhno, Mykhailo Shakhov   +2 more
doaj   +1 more source

A proximal distance algorithm for likelihood-based sparse covariance estimation. [PDF]

Biometrika, 2022
Xu J, Lange K.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Semilocal convergence of a family of third-order Chebyshev-type methods under a mild differentiability condition

, 2010
The aim of this paper is to establish the semilocal convergence of a family of third-order Chebyshev-type methods used for solving nonlinear operator equations in Banach spaces under the assumption that the second Frechet derivative of the operator ...
P. K. Parida, Gupta, D. K., D. K. Gupta, Parida, P. K.   +3 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

A Study on the Application of BP Neural Network Based on Visual Recognition in Regional Economic Forecasting. [PDF]

Comput Intell Neurosci, 2022
Meng L.
europepmc   +1 more source