Results 31 to 40 of about 188,346 (245)

Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization

Advanced Science, EarlyView.
This study shows that macrophage interferon regulatory factor 4 (IRF4) improved arterial injury‐induced neointimal hyperplasia by promoting of M2 polarization via up‐regulating krüppel‐like factor 4 (KLF4) in rodent and nonhuman primate models. Notably, artesunate is identified as a potent inducer of IRF4 in macrophages, and proposed as a promising ...
Jinlin Miao, Yule Yong, Zhaohui Zheng, Kui Zhang, Wei Li, Jiayi Liu, Siyi Zhou, Juan‐juan Qin, Haoyang Sun, Yatao Wang, Xianghui Fu, Xing Luo, Siyu Chen, Zhi‐Gang She, Jingjing Cai, Ping Zhu   +15 more
wiley   +1 more source

Fronteira, cana e tráfico: escravidão, doenças e mortes em Capivari, SP, 1821-1869

História, Ciências, Saúde: Manguinhos, 2015
Abordam-se as mortes e doenças de escravos no município canavieiro paulista de Capivari, associando as causas atribuídas a esses falecimentos ao contexto social e econômico e às características das comunidades escravas locais.
Carlos A.M Lima
doaj   +1 more source

Malária grave â Caso clínico

Revista Portuguesa de Pneumologia, 2011
Resumo: Apresenta-se o caso clínico de um doente regressado de Angola com malária grave, em que o índice de parasitémia inicial pelo P. falciparum era de 43%.Disfunção múltipla de órgãos, incluindo ARDS, implicaram o ingresso do doente numa unidade de alta vigilância, com sobrevivência do mesmo.Faz-se uma breve revisão do assunto, com ...
A. Pires, C. Capela, P. Gouveia, J.A. Mariz, G. Gomes, J.E. Oliveira   +5 more
openaire   +1 more source

Mechanisms of Baicalin Alleviates Intestinal Inflammation: Role of M1 Macrophage Polarization and Lactobacillus amylovorus

Advanced Science, EarlyView.
Baicalin alleviates E. coli‐induced intestinal inflammation through dual mechanisms: direct inhibition of the TLR4/IRF/STAT signaling pathway to modulate macrophage polarization and antigen presentation, thereby regulating Th17/Treg cell differentiation; and microbiota‐mediated indirect effects via increasing Lactobacillus amylovorus abundance and ...
Shunfen Zhang, Ruqing Zhong, Miao Zhou, Kai Li, Huiyuan Lv, Huixin Wang, Ye Xu, Dadan Liu, Qiugang Ma, Liang Chen, Hongfu Zhang   +10 more
wiley   +1 more source

Hemoglobinas humanas: hipótese malária ou efeito materno? Human hemoglobins: malaria hypothesis or maternal effect?

Revista Brasileira de Hematologia e Hemoterapia, 2005
As hemoglobinopatias têm provido uma das poucas demonstrações convincentes da seleção, influenciando a freqüência de único gene na população humana.
Felipe R. Torres, Claudia R. Bonini-Domingos   +1 more
doaj   +1 more source

Halofuginone Disrupted Collagen Deposition via mTOR‐eIF2α‐ATF4 Axis to Enhance Chemosensitivity in Ovarian Cancer

Advanced Science, EarlyView.
COL1A1, a major component of ECM, contributes to chemoresistance and poor prognosis in ovarian cancer. Halofuginone (HF) attenuates CAF‐secreted COL1A1 through mTOR‐eIF2α‐ATF4 axis. Notably, HF disrupts collagen deposition to form the looser ECM and facilitates CD8+ T cell infiltration, partially via M2‐M1 macrophage polarization to enhance ...
Wenxin Li, Yenan Wu, Yanan Zhang, Wenyan Gao, Xin Li, Haixia Luo, Mengmeng Lu, Zhihua Liu, Aiping Luo   +8 more
wiley   +1 more source

Manifestações neurológicas da malária

Arquivos de Neuro-Psiquiatria, 1972
Depois de revisão da literatura sobre manifestações neurológicas da malária, são relatados 6 casos de pacientes que estiveram em tratamento na Unidade Integrada de Saúde de Sobradinho (Brasília, DF), e que apresentavam formas graves de malária com ...
Fernando Guilhon Henriques
doaj   +1 more source

Electronic Nanomaterials for Plants: A Review on Current Advances and Future Prospects

Advanced Electronic Materials, EarlyView.
Global food security faces mounting challenges from climate change and rapid population growth. This review highlights the pivotal role of electronic nanomaterials–including metals, metal oxides, and carbon‐based structures–in enhancing plant photosynthesis, nutrient uptake, and stress resilience. Furthermore, it explores how emerging platforms such as
Ciro Allará, Giuseppe Ciccone, Manuela Ciocca, Sahira Vasquez, Pietro Ibba, Mauro Maver, Tanja Mimmo, Paolo Lugli, Luisa Petti   +8 more
wiley   +1 more source

Infecção pelo Plasmodium falciparum e gravidez: relato de casos

Revista da Sociedade Brasileira de Medicina Tropical, 1989
Em 1982 e em 1985 foram observados em Humaitá, Estado do Amazonas, respectivamente, uma criança lactente e uma gestante tercigesta, no segundo trimestre da gravidez, ambas com malária pelo Plasmodium falciparum. O lactente, masculino, natural do Amazonas
Domingos Alves Meira
doaj   +1 more source

Integrating Aggregate Materials and Machine Learning Algorithms: Advancing Detection of Pathogen‐Derived Extracellular Vesicles

Aggregate, EarlyView.
Pathogen‐derived extracellular vesicle detection: theoretical insights and advanced methodologies: This review explores the theoretical foundations and practical applications of pEV detection, emphasizing the challenges and innovative strategies involving novel aggregate materials and machine learning for enhanced diagnostic accuracy.
Lihan Lai, Yun Su, Cong Hu, Zehong Peng, Wei Xue, Liang Dong, Tony Y. Hu   +6 more
wiley   +1 more source