Results 41 to 50 of about 244,171 (199)

Cell Death of P. vivax Blood Stages Occurs in Absence of Classical Apoptotic Events and Induces Eryptosis of Parasitized Host Cells

Pathogens
Elucidation of pathways regulating parasite cell death is believed to contribute to identification of novel therapeutic targets for protozoan diseases, and in this context, apoptosis-like cell death has been reported in different groups of protozoa, in ...
Carolina Moreira Blanco, Hugo Amorim dos Santos de Souza, Priscilla da Costa Martins, Juliana Almeida-Silva, Ana Marcia Suarez-Fontes, Yury Oliveira Chaves, Marcos André Vannier-Santos, Lilian Rose Pratt-Riccio, Cláudio Tadeu Daniel-Ribeiro, Stefanie Costa Pinto Lopes, Paulo Renato Rivas Totino   +10 more
doaj   +1 more source

Optimization of Plasmodium vivax infection of colonized Amazonian Anopheles darlingi

Scientific Reports, 2023
Obtaining Plasmodium vivax sporozoites is essential for in vitro culture of liver stage parasites, not only to understand fundamental aspects of parasite biology, but also for drug and vaccine development.
Alice O. Andrade, Najara Akira C. Santos, Alessandra S. Bastos, José Daniel C. Pontual, Cristiane S. Araújo, Analice S. Lima, Leandro N. Martinez, Amália S. Ferreira, Anna Caroline C. Aguiar, Carolina B. G. Teles, Rafael V. C. Guido, Rosa A. Santana, Stefanie C. P. Lopes, Jansen F. Medeiros, Zaira Rizopoulos, Joseph M. Vinetz, Brice Campo, Marcus Vinicius G. Lacerda, Maisa S. Araújo   +18 more
doaj   +1 more source

Characterization of Immune Responses to RBD‐SD1 Nanoparticle Vaccines Derived From ACE2‐Capable HKU5‐CoV‐2, NeoCoV, and HKU5 Merbecoviruses

Biotechnology and Bioengineering, EarlyView.
SpyCatcher‐mi3 nanoparticles presenting HKU5, NeoCoV, and HKU5‐CoV‐2 RBD‐SD1 induced strong, cross‐reactive IgG responses in immunized mice. The surrogate virus neutralization test demonstrated strong activity in sera from homologous vaccination. ABSTRACT Recent discoveries of merbecoviruses such as HKU5, NeoCoV, and HKU5‐CoV‐2 that use angiotensin ...
Peter J. Halfmann, Jeong Soo Lee, Augustine Duffy, Tong Wang, Bingcheng Huang, James Z. Kurdi, Ajay Inampudi, Natasha Chen, Elizabeth Frimpong, Carmen Rai, Yoshihiro Kawaoka, Ravi S. Kane   +11 more
wiley   +1 more source

What impact did the Brazilian Federal Government’s intervention have on malaria cases in the Yanomami Indigenous lands?

Malaria Journal
Background The northern Brazilian state of Roraima has recently experienced an increase in malaria cases, mainly caused by illegal mining activities on indigenous lands.
Jacqueline de Aguiar Barros, Fabiana Granja, Pedro Eduardo Lima Siqueira, Ivyson da Silva Epifânio, Ronan Rocha Coelho, Maria Fátima Ferreira-da-Cruz   +5 more
doaj   +1 more source

The Juscelino Kubitschek government and the Brazilian Malaria Control and Eradication Working Group: collaboration and conflicts in Brazilian and international health agenda, 1958-1961

História, Ciências, Saúde: Manguinhos, 2015
Malaria, a disease which was under control in the beginning of Juscelino Kubitschek government, became the most important endemic disease in 1958, when Brazil made a commitment with the World Health Organization to convert its control programs into ...
Renato da Silva, Carlos Henrique Assunção Paiva   +1 more
doaj   +1 more source

A narrow bandgap Schottky heterojunction Fe2N/CeO2 microneedle triggering sonodynamic reactive oxygen species storm for drug‐resistance‐free skin fungal infection

BMEMat, EarlyView.
Inorganic sonosensitizers suffer from inefficient electron‐hole separation, rapid recombination, and wide bandgaps in anti‐fungal applications. We propose MN@Fe2N/CeO2 to directly eliminate fungi without drug resistance. Combining semiconductor CeO2's advantages with Fe2N's high work function and activity enables efficient Schottky heterojunctions ...
Li Wang, Jiayi Yang, Ning Tang, Youbin Zheng, Yichao Hou, Chutong Liu, Lihao Guo, Yingying Liao, Gandong Zhou, Weiwei Wu, Xin Du, Shuxiang Xu, Jie Yin, Miaomiao Yuan   +13 more
wiley   +1 more source

Are pvcrt-o and pvmdr1 Gene Mutations Associated with Plasmodium vivax Chloroquine-Resistant Parasites?

Biomedicines
(1) Background: Malaria remains a significant global public health issue. Since parasites quickly became resistant to most of the available antimalarial drugs, treatment effectiveness must be constantly monitored.
Rebecca de Abreu-Fernandes, Natália Ketrin Almeida-de-Oliveira, Aline Rosa de Lavigne Mello, Lucas Tavares de Queiroz, Jacqueline de Aguiar Barros, Bárbara de Oliveira Baptista, Joseli Oliveira-Ferreira, Rodrigo Medeiros de Souza, Lilian Rose Pratt-Riccio, Patrícia Brasil, Cláudio Tadeu Daniel-Ribeiro, Maria de Fátima Ferreira-da-Cruz   +11 more
doaj   +1 more source

O Plano de Saneamento da Amazônia (1940-1942) The Amazon Sanitation Plan (1940-1942)

História, Ciências, Saúde: Manguinhos, 2007
Aborda o Plano de Saneamento da Amazônia e o contexto político de sua formulação, entre 1940 e 1941, o papel de Getúlio Vargas, a atuação de seus principais protagonistas como Evandro Chagas, João de Barros Barreto e Valério Konder, as suas principais ...
Rômulo de Paula Andrade, Gilberto Hochman   +1 more
doaj   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Comissão Rondon, doenças e política: "Região do Madeira: Santo Antônio", de Joaquim Augusto Tanajura - uma outra visão do Alto Madeira em 1911 The Rondon Commission, diseases, and politics: "Região do Madeira: Santo Antônio," by Joaquim Augusto Tanajura - another view of the Alto Madeira in 1911

História, Ciências, Saúde: Manguinhos, 2011
Comenta o artigo "Região do Madeira: Santo Antônio", do médico Joaquim Augusto Tanajura (1878-1941), chefe do serviço de saúde da Comissão Rondon de 1909 a 1912.
André Vasques Vital
doaj   +1 more source