Results 71 to 80 of about 471,764 (290)

Amazon deforestation drives malaria transmission, and malaria burden reduces forest clearing

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Widespread human impacts on the environment are expected to harm human health, which may in turn alter our interactions with the environment.
Andrew J. MacDonald, E. Mordecai
semanticscholar   +1 more source

Discovery of an Atypical Arp2/3 Complex in Malaria Parasites Sheds New Light on Nuclear Actin

Cytoskeleton, EarlyView.
ABSTRACT The Arp2/3 complex is a key actin nucleator essential for cytoskeletal dynamics in eukaryotes. Previously believed absent in apicomplexan parasites, we recently identified an atypical Arp2/3 complex in malaria parasites consisting of five divergent subunits and a putative kinetochore‐associated factor.
Franziska Hentzschel, Friedrich Frischknecht, Matthias Marti   +2 more
wiley   +1 more source

Geographic information systems and logistic regression for high-resolution malaria risk mapping in a rural settlement of the southern Brazilian Amazon [PDF]

, 2013
BACKGROUND: In Brazil, 99% of the cases of malaria are concentrated in the Amazon region, with high level of transmission. The objectives of the study were to use geographic information systems (GIS) analysis and logistic regression as a tool to identify
Elaine de Oliveira, Emerson dos Santos, Marina Atanaka-Santos, Peter Zeilhofer, Reinaldo Souza-Santos   +4 more
core   +1 more source

Windborne long-distance migration of malaria mosquitoes in the Sahel

Nature, 2019
Over the past two decades efforts to control malaria have halved the number of cases globally, yet burdens remain high in much of Africa and the elimination of malaria has not been achieved even in areas where extreme reductions have been sustained, such
D. Huestis, A. Dao, M. Diallo, Z. L. Sanogo, D. Samaké, A. Yaro, Yossi Ousman, Y. Linton, A. Krishna, Laura M. Verú, Benjamin J. Krajacich, R. Faiman, J. Florio, J. Chapman, D. Reynolds, D. Weetman, R. Mitchell, M. Donnelly, E. Talamas, L. Chamorro, E. Strobach, T. Lehmann   +21 more
semanticscholar   +1 more source

A White Paper on Advancing Long‐Acting Therapeutics for Maternal and Pediatric Health by Bridging Gaps in Clinical Research, Access and Regulation

Clinical Pharmacology &Therapeutics, EarlyView.
As use cases for long‐acting therapeutics expand across clinical indications, there is a critical need to ensure the inclusion of women who are pregnant or breastfeeding, infants and children—populations with a historical gap in the availability of interventions already approved for use in adults.
Moherndran Archary, Robert Bies, Osei Boateng, Rachel Daley, Pierre Gashema, Mili Karina, Emily Njuguna, Sharon Nachman, Nathaniel Nkrumah, Carolyne Odula, Andrew Owen, Ethel D. Weld, Prajith Venkatasubramanian, Adeniyi Olagunju, on behalf of the Community of Practice for Long‐acting Therapeutics for Maternal and Paediatric Health, Rana Abutaima, Dorothy Akongo, Abdulnaser Alsharaa, Moherndran Archary, Shakir Atoyebi, Benoit Bestgen, Robert Bies, Osei Boateng, Andrew Butler, Edmund Capparelli, Rachel Daley, Layla Davies, Joelle Dountio, Henry Enzama, Pierre Gashema, Katila George, Dan Hawcutt, Rene Holm, Patrick Gad Iradukunda, Elodie Jambert, Mili Karina, Linda Lewis, Grace Miheso, Sebastien Morin, Andrew Morrison, Sharon Nachman, Shadia Nakalema, Emily Njunga, Nathaniel Nkrumah, Carolyne Odula‐Obonyo, Brenda Okware, Adeniyi Olagunju, Andrew Owen, Martina Penazzato, Natella Rakhmanina, Mphako Brighton Ratlabyana, Rachel Scott, Kimberly Struble, Andre‐Marie Tchouatieu, Catherine Unsworth, Prajith Venkatasubramanian, Catriona Waitt, Ethel Weld, Janine Winterbottom, Leena Zino   +59 more
wiley   +1 more source

Cell Death of P. vivax Blood Stages Occurs in Absence of Classical Apoptotic Events and Induces Eryptosis of Parasitized Host Cells

Pathogens
Elucidation of pathways regulating parasite cell death is believed to contribute to identification of novel therapeutic targets for protozoan diseases, and in this context, apoptosis-like cell death has been reported in different groups of protozoa, in ...
Carolina Moreira Blanco, Hugo Amorim dos Santos de Souza, Priscilla da Costa Martins, Juliana Almeida-Silva, Ana Marcia Suarez-Fontes, Yury Oliveira Chaves, Marcos André Vannier-Santos, Lilian Rose Pratt-Riccio, Cláudio Tadeu Daniel-Ribeiro, Stefanie Costa Pinto Lopes, Paulo Renato Rivas Totino   +10 more
doaj   +1 more source

The Juscelino Kubitschek government and the Brazilian Malaria Control and Eradication Working Group: collaboration and conflicts in Brazilian and international health agenda, 1958-1961

História, Ciências, Saúde: Manguinhos, 2015
Malaria, a disease which was under control in the beginning of Juscelino Kubitschek government, became the most important endemic disease in 1958, when Brazil made a commitment with the World Health Organization to convert its control programs into ...
Renato da Silva, Carlos Henrique Assunção Paiva   +1 more
doaj   +1 more source

Internal validity of clinical trials for Plasmodium vivax malaria treatment [PDF]

, 2003
Resistência parasitária pode ser definida como a habilidade da cepa parasitária de sobreviver e/ou multiplicar, a despeito da administração e absorção da medicação dada em doses iguais ou superiores àquelas usualmente recomendadas, porém dentro do limite
Duarte, Elisabeth Carmen, Fontes, Cor Jesus Fernandes, Pang, Lorrin   +2 more
core   +1 more source

Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib

Clinical Pharmacology &Therapeutics, EarlyView.
Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi, Mwila Mulubwa, Mmakwena M. Mmonwa, Mathew Njoroge, Liezl Krugmann, Kelly Chibale   +5 more
wiley   +1 more source

O Plano de Saneamento da Amazônia (1940-1942) The Amazon Sanitation Plan (1940-1942)

História, Ciências, Saúde: Manguinhos, 2007
Aborda o Plano de Saneamento da Amazônia e o contexto político de sua formulação, entre 1940 e 1941, o papel de Getúlio Vargas, a atuação de seus principais protagonistas como Evandro Chagas, João de Barros Barreto e Valério Konder, as suas principais ...
Rômulo de Paula Andrade, Gilberto Hochman   +1 more
doaj   +1 more source