Results 21 to 30 of about 270,836 (221)

Spread of artemisinin resistance in Plasmodium falciparum malaria.

New England Journal of Medicine, 2014
BACKGROUND Artemisinin resistance in Plasmodium falciparum has emerged in Southeast Asia and now poses a threat to the control and elimination of malaria.
E. Ashley, M. Dhorda, R. Fairhurst, C. Amaratunga, P. Lim, Seila Suon, Sokunthea Sreng, Jennifer M. Anderson, Sivanna Mao, Baramey Sam, Chantha Sopha, Char Meng Chuor, C. Nguon, S. Sovannaroth, S. Pukrittayakamee, P. Jittamala, K. Chotivanich, K. Chutasmit, C. Suchatsoonthorn, R. Runcharoen, T. Hien, Nguyen T Thuy-Nhien, N. V. Thanh, N. Phu, Y. Htut, K. Han, K. H. Aye, O. Mokuolu, Rasaq R Olaosebikan, O. Folaranmi, M. Mayxay, Maniphone Khanthavong, B. Hongvanthong, P. Newton, M. Onyamboko, C. Fanello, A. Tshefu, N. Mishra, N. Valecha, A. Phyo, F. Nosten, P. Yi, R. Tripura, S. Borrmann, M. Bashraheil, J. Peshu, M. A. Faiz, A. Ghose, M. Hossain, Rasheda Samad, M. R. Rahman, M. Hasan, Akhterul Islam, Olivo Miotto, R. Amato, B. MacInnis, J. Stalker, D. Kwiatkowski, Zbynek Bozdech, Atthanee Jeeyapant, P. Cheah, Tharisara Sakulthaew, Jeremy Chalk, B. Intharabut, K. Silamut, Sue J Lee, Benchawan Vihokhern, Chanon Kunasol, M. Imwong, J. Tarning, W. J. Taylor, S. Yeung, C. Woodrow, J. Flegg, D. Das, Jeffery L. Smith, M. Venkatesan, C. Plowe, K. Stepniewska, P. Guérin, A. Dondorp, N. Day, N. White   +82 more
semanticscholar   +1 more source

Haematological parameters, haemozoin-containing leukocytes in Sudanese children with severe Plasmodium falciparum malaria

Journal of Infection in Developing Countries, 2018
Introduction: Haemozoin –containing leucocytes (HCL) can be used to predict severe malaria. Methodology: A case –control study was conducted in Singa, Sudan, to investigate the haematological values and HCL in children with severe Plasmodium ...
Magdi M Salih, Hatim G Eltahir, Tajeldin M Abdallah, Tariq E Elmahdi, Ammar H Khamis, Elfatih E Malik, Ishag Adam   +6 more
doaj   +1 more source

Pancreatitits aguda necroticohemorrágica en malaria falciparum

, 2016
espanolLa malaria o paludismo es una patologia causada por un parasito denominado Plasmodium, propia de paises tropicales. Entre la sintomatologia mas frecuente destaca la malaria cerebral, ictericia, crisis convulsivas, anemia, hipoglucemia, fallo renal
Reoyo Pascual Jf, C. Cartón-Hernández, X. Valero-Cerrato, R. León-Miranda, E. García-Plata-Polo, R. Martínez-Castro, Álvarez-Rico Má, Sánchez-Manuel Fj   +7 more
semanticscholar   +1 more source

Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1‐based vaccines to prevent it

Immunological Reviews, 2019
Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites have the unique capacity to infect and replicate within host erythrocytes.
Anja T. R. Jensen, Y. Adams, L. Hviid
semanticscholar   +1 more source

Hyponatraemia in imported malaria is common and associated with disease severity

Malaria Journal, 2010
Background Hyponatraemia (serum sodium < 135 mmol/L) has long been recognized as a complication of malaria. However, few studies have been done in non-immune adult populations.
Hoorn Ewout J, Zietse Robert, Hesselink Dennis A, van Wolfswinkel Marlies E, van Genderen Perry JJ   +4 more
doaj   +1 more source

A comparison of thick-film microscopy, rapid diagnostic test, and polymerase chain reaction for accurate diagnosis of Plasmodium falciparum malaria

Malaria Journal, 2019
Accurate diagnosis of malaria is important for effective disease management and control. In Cameroon, presumptive clinical diagnosis, thick-film microscopy (TFM), and rapid diagnostic tests (RDT) are commonly used to diagnose cases of Plasmodium ...
Kenji O. Mfuh, O. Achonduh-Atijegbe, O. N. Bekindaka, L. Esemu, C. D. Mbakop, K. Gandhi, R. Leke, D. Taylor, V. Nerurkar   +8 more
semanticscholar   +1 more source

First‐in‐human safety, tolerability, pharmacokinetics and pilot food‐effect study of the candidate antimalarial compound MMV367

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim To evaluate the safety, tolerability and pharmacokinetics in healthy participants of orally administered MMV367 (GSK3772701), a novel antimalarial interfering with Plasmodium falciparum acyl coenzyme A synthetase 10/11 function. Methods This first‐in‐human study enrolled 47 healthy male and female participants.
Andrea Kuemmerle, Nand Singh, Denis Gossen, Annick Janin, Raman Sharma, Anthony Cahn, Rachel A. Gibson, Somasekhara R. Menakuru, Erin Lambourne, Tom Dove, Francisco‐Javier Gamo, Laura Sanz, Benoit Bestgen, Stephan Chalon   +13 more
wiley   +2 more sources

Sticking for a Cause: The Falciparum Malaria Parasites Cytoadherence Paradigm

Frontiers in Immunology, 2019
After a successful invasion, malaria parasite Plasmodium falciparum extensively remodels the infected erythrocyte cellular architecture, conferring cytoadhesive properties to the infected erythrocytes. Cytoadherence plays a central role in the parasite's
Wenn-Chyau Lee, B. Russell, L. Rénia
semanticscholar   +1 more source

Risk Factors for Imported Fatal Plasmodium falciparum Malaria, France, 1996–2003

Emerging Infectious Diseases, 2007
Plasmodium falciparum malaria is a serious health hazard for travelers to malaria-endemic areas and is often diagnosed on return to the country of residence.
Fabrice Legros, Olivier Bouchaud, Thierry Ancelle, Amandine Arnaud, Sandrine Cojean, Jacques Le Bras, Martin Danis, Arnaud Fontanet, Rémy Durand, Autochthonous Malaria Epidemiology   +9 more
doaj   +1 more source

Adaptive NK cells in people exposed to Plasmodium falciparum correlate with protection from malaria

Journal of Experimental Medicine, 2019
Plasmodium falciparum–infected individuals in a malaria-endemic region have an abundance of adaptive NK cells that correlates with resistance to malaria. Adaptive NK cells dominate antibody-dependent responses to P.
G. Hart, T. Tran, J. Theorell, Heinrich Schlums, G. Arora, S. Rajagopalan, A. D. J. Sangala, Kerry J. Welsh, B. Traore, S. Pierce, Peter D. Crompton, Y. Bryceson, Eric O Long   +12 more
semanticscholar   +1 more source