Results 21 to 30 of about 60,838 (174)

FALCIPARUM MALARIA

The Professional Medical Journal, 2011
Introduction: Quinine and quinidines remain the drugs of choice for chloroquine resistant Plasmodium falciparum malaria. In 1972, Chinese scientists discovered the antimalarial properties of a group of compounds from the qinghao plant (Artemisia annua) which have activity against all malaria causing parasites including multi-drug resistant strains of ...
SYED GHAZANFAR MEHDI, NAEEM NAQI
openaire   +2 more sources

Rising report of Plasmodium vivax in sub-Saharan Africa: Implications for malaria elimination agenda

Scientific African, 2020
Plasmodium vivax and P. falciparum are the most important human malaria species. P. falciparum is considered the most virulent and widespread species in sub-Saharan Africa.
Mary Aigbiremo Oboh, Kolapo Muyiwa Oyebola, Emmanuel Taiwo Idowu, Aida Sadikh Badiane, Olubunmi Adetoro Otubanjo, Daouda Ndiaye   +5 more
doaj   +1 more source

Prevalence of asymptomatic non-falciparum and falciparum malaria in the 2014-15 Rwanda Demographic Health Survey.

PLoS ONE
BackgroundRecent molecular surveillance suggests an unexpectedly high prevalence of non-falciparum malaria in Africa. Malaria control is also challenged by undetected asymptomatic P. falciparum malaria resulting in an undetectable reservoir for potential
Claudia Gaither, Camille Morgan, Rebecca Kirby, Corine Karema, Pierre Gashema, Jenna Zuromski, Samuel J White, Hillary M Topazian, David Giesbrecht, Kyaw Thwai, Neeva Wernsman Young, Varun Goel, Koby Boyter, Tharcisse Munyaneza, Claude Mambo Muvunyi, Jean De Dieu Butera, Jeffrey A Bailey, Jean-Baptiste Mazarati, Jonathan J Juliano   +18 more
doaj   +1 more source

HIV Malaria Co-Infection Is Associated with Atypical Memory B Cell Expansion and a Reduced Antibody Response to a Broad Array of Plasmodium falciparum Antigens in Rwandan Adults. [PDF]

PLoS ONE, 2015
HIV infected individuals in malaria endemic areas experience more frequent and severe malaria episodes compared to non HIV infected. This clinical observation has been linked to a deficiency in antibody responses to Plasmodium falciparum antigens ...
Krishanthi S Subramaniam, Jeff Skinner, Emil Ivan, Eugene Mutimura, Ryung S Kim, Catherine M Feintuch, Silvia Portugal, Kathryn Anastos, Peter D Crompton, Johanna P Daily   +9 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Non-falciparum malaria infections in Uganda, does it matter? A review of the published literature

Malaria Journal
Background Plasmodium falciparum is the dominant malaria species in the sub-Saharan Africa and the main cause of severe disease and death. Notwithstanding, severe malaria and death due to non-falciparum infections have been reported, but at much lower ...
Mansour Ranjbar, Yonas Tegegn Woldemariam   +1 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Rapid antigen detection tests for malaria diagnosis in severely ill Papua New Guinean children: a comparative study using Bayesian latent class models. [PDF]

PLoS ONE, 2012
BACKGROUND: Although rapid diagnostic tests (RDTs) have practical advantages over light microscopy (LM) and good sensitivity in severe falciparum malaria in Africa, their utility where severe non-falciparum malaria occurs is unknown.
Laurens Manning, Moses Laman, Anna Rosanas-Urgell, Berwin Turlach, Susan Aipit, Cathy Bona, Jonathan Warrell, Peter Siba, Ivo Mueller, Timothy M E Davis   +9 more
doaj   +1 more source

An Imported Case of Afebrile Plasmodium falciparum Malaria Infection from Tanzania in a Returning Traveler to the Republic of Korea following an Earlier COVID-19 Infection

Tropical Medicine and Infectious Disease, 2022
Malaria is well-known as one of the most common causes of fever among travelers returning from endemic areas such as tropical African countries. However, afebrile Plasmodium falciparum malaria has rarely been reported in a returning traveler with no ...
Chaeryoung Lee, Sung Kwan Hong, Jong Hun Kim   +2 more
doaj   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source