Results 161 to 170 of about 249,029 (275)

Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolution [PDF]

open access: yes, 2017
Elucidation of the evolutionary history and interrelatedness of Plasmodium species that infect humans has been hampered by a lack of genetic information for three human-infective species: P. malariae and two P. ovale species (P. o. curtisi and P.
Amenga-Etego, Lucas   +21 more
core   +2 more sources

PBPK‐Led Assessment of Antimalarial Drug Concentrations in Breastmilk: A Strategy for Optimal Use of Prediction Methods to Guide Decision Making in an Understudied Population

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 4, Page 738-750, April 2025.
ABSTRACT Treatment of breastfeeding mothers with malaria is challenging due to the lack of information describing drug exposure in milk and the daily dose to the breastfed infant. Physiologically based pharmacokinetic (PBPK) modeling was used to predict milk‐to‐plasma (M/P) ratios, infant daily doses (IDD) and relative infant doses (RID) for five ...
Lisa M. Almond   +11 more
wiley   +1 more source

Antimalarial Activity of KAF156 in Falciparum and Vivax Malaria.

open access: yesNew England Journal of Medicine, 2016
BACKGROUND KAF156 belongs to a new class of antimalarial agents (imidazolopiperazines), with activity against asexual and sexual blood stages and the preerythrocytic liver stages of malarial parasites.
N. White   +19 more
semanticscholar   +1 more source

Long-term sustained malaria control leads to inbreeding and fragmentation of Plasmodium vivax populations [PDF]

open access: yesarXiv, 2016
Plasmodium vivax populations are more resistant to malaria control strategies than Plasmodium falciparum, maintaining high genetic diversity and gene flow even at low transmission. To quantify the impact of declining transmission on P. vivax populations, we investigated population genetic structure over time during intensified control efforts and over ...
arxiv  

Graphene in the fight against malaria [PDF]

open access: yesarXiv, 2020
Malaria infection is a major public health worldwide, with millions of new cases and creating huge direct (an indirect) economic losses annually. Thus, the availability of preventive methods and diagnostic solutions for malaria is critical to save many lives, especially in poor countries.
arxiv  

A spatial predictive model for Malaria resurgence in central Greece integrating entomological, environmental and Social data [PDF]

open access: yes, 2017
Malaria constitutes an important cause of human mortality. After 2009 Greece experienced a resurgence of malaria. Here, we develop a modelbased framework that integrates entomological, geographical, social and environmental evidence in order to guide the mosquito control efforts and apply this framework to data from an entomological survey study ...
arxiv   +1 more source

Genome-wide diversity and differentiation in New World populations of the human malaria parasite Plasmodium vivax

open access: yesPLoS Neglected Tropical Diseases, 2017
Background The Americas were the last continent colonized by humans carrying malaria parasites. Plasmodium falciparum from the New World shows very little genetic diversity and greater linkage disequilibrium, compared with its African counterparts, and ...
Thaís C. de Oliveira   +14 more
semanticscholar   +1 more source

Shrinking the Malaria Map: A Prospectus on Malaria Elimination [PDF]

open access: yes, 2009
\ud Thirty-nine countries across the world are making progress toward malaria elimination. Some are committed to nationwide elimination, while others are pursuing spatially progressive elimination within their borders.
Feachem, Richard G.A.   +2 more
core  

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