Results 1 to 10 of about 8,099 (144)

Simplified and Rapid Determination of Primaquine and 5,6-Orthoquinone Primaquine by UHPLC-MS/MS: Its Application to a Pharmacokinetic Study

Molecules, 2021
The method for the determination of primaquine (PQ) and 5,6-orthoquinone primaquine (5,6-PQ), the representative marker for PQ active metabolites, via CYP2D6 in human plasma and urine has been validated.
Supeecha Wittayalertpanya, Mathirut Mungthin, Chonlaphat Sukasem   +2 more
exaly   +3 more sources

An increase in urinary primaquine and a reduction in urinary primaquine-5,6-orthoquinone in the Thai population with CYP2D6 reduced enzyme function

Heliyon
Objectives: Primaquine is metabolized by the cytochrome P450-2D6 enzyme (CYP2D6) to an active primaquine-5,6-orthoquinone (POQ). No relationships of CYP2D6 polymorphisms with the pharmacokinetics of primaquine and POQ were reported in the Thai population.
Supeecha Wittayalertpanya, Mathirut Mungthin, Chonlaphat Sukasem   +2 more
exaly   +3 more sources

The antimalarial drug primaquine targets Fe–S cluster proteins and yeast respiratory growth

Redox Biology, 2016
Malaria is a major health burden in tropical and subtropical countries. The antimalarial drug primaquine is extremely useful for killing the transmissible gametocyte forms of Plasmodium falciparum and the hepatic quiescent forms of P. vivax.
Cindy Vallières, Jérôme Clain, Simon Avery   +2 more
exaly   +3 more sources

Unsupervised primaquine for the treatment of Plasmodium vivax malaria relapses in southern Papua: A hospital-based cohort study

PLoS Medicine, 2017
BackgroundPrimaquine is the only licensed drug for eradicating Plasmodium vivax hypnozoites and, therefore, preventing relapses of vivax malaria. It is a vital component of global malaria elimination efforts.
Michael Malloy, Enny Kenangalem, Nicholas Anstey   +2 more
exaly   +2 more sources

Primaquine and Chloroquine Fumardiamides as Promising Antiplasmodial Agents

Molecules, 2019
This paper describes a continuation of our efforts in the pursuit of novel antiplasmodial agents with optimized properties. Following our previous discovery of biologically potent asymmetric primaquine (PQ) and halogenaniline fumardiamides (1−6 ...
Diana Fontinha, Marijeta Kralj, Jana Held   +2 more
exaly   +3 more sources

Genetic Variation of G6PD and CYP2D6: Clinical Implications on the Use of Primaquine for Elimination of Plasmodium vivax

Frontiers in Pharmacology, 2021
Primaquine, an 8-aminoquinoline, is the only medication approved by the World Health Organization to treat the hypnozoite stage of Plasmodium vivax and P. ovale malaria.
Alexandra G. A. Stewart, Peter A. Zimmerman, James S. McCarthy, James S. McCarthy   +3 more
doaj   +1 more source

Safety of single-dose primaquine as a Plasmodium falciparum gametocytocide: a systematic review and meta-analysis of individual patient data

BMC Medicine, 2022
Background In 2012, the World Health Organization (WHO) recommended single low-dose (SLD, 0.25 mg/kg) primaquine to be added as a Plasmodium (P.) falciparum gametocytocide to artemisinin-based combination therapy (ACT) without glucose-6-phosphate ...
Kasia Stepniewska, Elizabeth N. Allen, Georgina S. Humphreys, Eugenie Poirot, Elaine Craig, Kalynn Kennon, Daniel Yilma, Teun Bousema, Philippe J. Guerin, Nicholas J. White, Ric N. Price, Jaishree Raman, Andreas Martensson, Richard O. Mwaiswelo, Germana Bancone, Guido J. H. Bastiaens, Anders Bjorkman, Joelle M. Brown, Umberto D’Alessandro, Alassane A. Dicko, Badria El-Sayed, Salah-Eldin Elzaki, Alice C. Eziefula, Bronner P. Gonçalves, Muzamil Mahdi Abdel Hamid, Akira Kaneko, Simon Kariuki, Wasif Khan, Titus K. Kwambai, Benedikt Ley, Billy E. Ngasala, Francois Nosten, Joseph Okebe, Aaron M. Samuels, Menno R. Smit, Will J. R. Stone, Inge Sutanto, Feiko Ter Kuile, Roger C. Tine, Alfred B. Tiono, Chris J. Drakeley, Roly Gosling, Andy Stergachis, Karen I. Barnes, Ingrid Chen   +44 more
doaj   +1 more source

Effects of co-treatment of Plasmodium berghei-infected mice with aqueous extract of Ocimum gratissimum leaves and primaquine on glucose-6-phosphate dehydrogenase activity, hematological, and antioxidant parameters

Journal of Ayurveda and Integrative Medicine, 2022
Background: It has been observed that most malaria patients especially G6PD-deficient patients usually experience oxidative stress and severe anemia when treated with primaquine.
Shedrach Kanu C, Chinyere Aloke, Nwabueze Elom I, Chinedum Eleazu O   +3 more
doaj   +1 more source

Optimal timing of primaquine to reduce Plasmodium falciparum gametocyte carriage when co-administered with artemether–lumefantrine

Malaria Journal, 2020
Background Primaquine is an important gametocytocidal drug that is combined with conventional malaria treatment for prevention of Plasmodium falciparum malaria transmission.
Seif Shekalaghe, Dominic Mosha, Ali Hamad, Thabit A. Mbaga, Michael Mihayo, Teun Bousema, Chris Drakeley, Salim Abdulla   +7 more
doaj   +1 more source

Increased primaquine total dose prevents Plasmodium vivax relapses in patients with impaired CYP2D6 activity: report of three cases

Malaria Journal, 2021
Background The relapsing nature of Plasmodium vivax infection is a major barrier to its control and elimination. Factors such as adequate dosing, adherence, drug quality, and pharmacogenetics can impact the effectiveness of radical cure of P.
Anielle de Pina-Costa, Ana Carolina Rios Silvino, Edwiges Motta dos Santos, Renata Saraiva Pedro, José Moreira, Gabriela Liseth Umana, Ana Danielle Tavares da Silva, Otília Helena Lupi da Rosa Santos, Karina Medeiros de Deus Henriques, Cláudio Tadeu Daniel-Ribeiro, Patrícia Brasil, Tais Nobrega Sousa, André M. Siqueira   +12 more
doaj   +1 more source